Klenzit gel user manual
You can buy Klenzit on this page
Composition
1 gram of gel contains 1 mg of Adapalene - the active substance.
Auxiliary Ingredients:
propylene glycol;
disodium edetate;
methylparahydroxybenzoate;
carbomer 940 (carbopol 940);
phenoxyethanol;
sodium hydroxide;
poloxamer 407;
purified water.
Form of issue
The drug is available in the form of a gel for external use.
The package contains 1 tube of 0.1% gel for 15 g or 30 g.
pharmachologic effect
Anti-inflammatory, comedolitic.
Pharmacodynamics and pharmacokinetics
The topical drug of the gel is intended for the treatment of acne. The active substance of the drug is a retinoid derivative - Adapalene, which exhibits anti-inflammatory and comedonolytic activity. Adapalen takes part in the normalization of the processes of epidermal differentiation and keratinization, inhibits the formation of micro-medones and reduces the manifestations of the inflammatory process.
The mechanism of action of the active substance of the drug Klenzit lies in its ability to influence the specific gamma receptors of epidermal cells of the skin, reducing their adhesion surface in the mouths of the sebaceous-hair follicles.
In vivo and in vitro studies have shown that Adapalene has a pronounced anti-inflammatory effect, due to its influence on the factors of the inflammatory process. Inhibits the metabolism of arachidonic acid and migration of leukocytes.
When the gel is applied externally, the systemic absorption of its active substance Adapalene is rather low, about 4% of the used dose.
From the systemic blood flow, excreted by the liver.
Indications for use
Acne rash (acne).
Contraindications
hypersensitivity to Adapalene and other ingredients of the drug;
lactation period;
period of pregnancy.
Use with caution in eczema and dermatitis.
Side effects
Therapy with the use of gel Klenzit is mostly well tolerated. In rare cases, observed hyperemia, irritation, peeling of the skin. In the event of these complications, it is recommended to temporarily suspend therapy, with the resumption after the disappearance of these effects.
Single cases of the development of allergic manifestations, which were the cause of the complete withdrawal of treatment, are described.
Instructions for use (Method and dosage)
The drug is used exclusively topically (externally).
Before applying the gel, the instruction on Klenzit recommends thoroughly cleaning and drying the problem areas of the skin of the face.
With light touches, evenly distribute the gel on the surface affected by acne. Apply Clenzit drug should be 1 time per day, best of all in the evening, while trying not to touch the cavity of the nose and mouth, as well as the mucous eye.
Therapeutic effect is observed 1-2 months after the start of treatment and achieves a stable positive effect after 3 months of therapy.
In rare cases, due to the ongoing irritation of the skin, treatment can be suspended until the symptoms of irritation disappear.
After consultation with the attending physician, a repeat course of therapy is possible.
Overdose
With external application of the drug, an overdose is unlikely.
In the case of an occasional internal gel intake, a standard therapy with gastric lavage and the administration of enterosorbents is carried out.
Interaction
When applying the drug Klenzit in the evening, it is acceptable to use other anti-acne preparations the next morning.
Simultaneous use of Klenzit gel and products with drying and irritating properties (cologne, alcohol solutions) is not recommended.
It is allowed to co-prescribe with Benzoyl peroxide and Clindamycin.
Storage conditions
At a temperature of no higher than 25 ° C.
Shelf life - 24 months.
special instructions
In case of accidental ingestion of medication in the oral cavity and nose, as well as the eye mucosa, it is necessary to rinse them thoroughly with warm water.
It is recommended to avoid the influence of direct sunlight on the areas of the skin with the applied gel, because of the possible development of skin irritation.
During pregnancy (and lactation)
The use of Klenzit during pregnancy and breastfeeding is contraindicated.
Reviews about Klenzit
Looking at the various pages of websites devoted to the problem of facial skin and in particular acne (acne), it can be noted that considering local medicines to help get rid of acne, reviews about Klenzit are mostly positive. Of course, if you want to overcome this problem at a time, then this drug is not for you. The treatment process is rather long (a persistent effect occurs after 3 months of use) and requires additional facial skin care, as after the application of the drug, dry skin often arises, which must be moistened. Gel Klenzit is very economical and therapy with its use allows the parallel use, after some interruption, of other dermatological agents. It is worth noting that Klenzit is not suitable for everyone, so before you start treating acne, consult a dermatologist who, in case of any contraindications, can assign the appropriate analogue.
The difference between Klenzit and Klenzit C
The main difference between these drugs is that the Klenzit C gel contains, in addition to Adapaline, a retinoid metabolite, a bacteriostatic antibiotic, Clindamycin, which is active against purulent inflammations caused by certain Gram-positive cocci.
In the treatment of acne, with the positive reaction of the body to Adapalen and Clindamycin, it is best not to choose between Klenzit or Klenzit C, but to apply them in general treatment. First, use Klenzit C for about 2 weeks, then switch to the application of Klenzit.
