Zovirax cream 5% 5gr

Zovirax cream instruction

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Composition

    In the composition of 1 gram of Zovirax cream is 50 mg of acyclovir. Auxiliary components: dimethicone, paraffin white, propylene glycol, cetostearyl alcohol, poloxamer 407, liquid paraffin, sodium lauryl sulfate, macrogol stearate, glycerol monostearate, water.

Form of issue

White homogeneous cream 5% for external use.
    2 grams of cream in a plastic vial plastic with a dispenser; one bottle in a paper bundle.
    2, 5 or 10 grams of cream in an aluminum tube, 1 tube in a paper bundle.

pharmachologic effect

Antiviral action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

An antiviral drug, an artificial analogue of a purine-type nucleoside, which has the ability to inhibit the replication of all herpes simplex virus (HSV) viruses, Varicella zoster, cytomegalovirus and Epstein-Barr. Acyclovir has the most pronounced antiviral properties against the herpes simplex virus of the first type.
The effect of the drug on viruses is highly selective. Thymidine kinase of cells infected with these viruses converts acyclovir molecules to monophosphate, then sequentially into diphosphate and triphosphate under the action of cell enzymes. The inclusion of the triphosphate of the active substance in the DNA strand of the virus and the subsequent breakage of this chain block the copying of the viral DNA.
In patients with pronounced immunodeficiency, prolonged or repeated courses of treatment with acyclovir can lead to the emergence of drug-resistant strains. Many strains with reduced sensitivity to Zovirax have a low concentration of viral thymidine kinase.

Pharmacokinetics of Zovirax cream

With repeated use of the cream with acyclovir, systemic absorption is minimal.

Indications for use

Indications for the use of Zovirax cream:

    infectious lesions of HSV of all skin types and mucous membranes, including herpes lips.

Contraindications

    Allergy to acyclovir or Valaciclovir or the components of the drug.
    Contraindications for intravenous administration of the drug: renal failure, dehydration, reactions to intravenous administration of cytotoxic drugs (including in the past), neurological disorders, pregnancy.
    Contraindications if taken orally: renal failure, dehydration.

Side effects

Side effects when using cream

    Local reactions: temporary itching, redness, burning, peeling, tingling in the area of ​​application.
    Allergic reactions: dermatitis, angioedema.

Instructions for use Zovirax (Method and dosage)

Cream Zovirax, instructions for use

Cream Zoviraks put a cotton swab or pre-washed hands to avoid re-infection of affected areas.
A small amount of the drug is applied to the affected and adjacent areas of the skin and mucous to 5 times a day.
Duration of treatment is usually 4 days. In the absence of healing, it can be prolonged up to 10 days. If after 10 days of treatment the symptoms of the disease persist, you need to consult a doctor.

Overdose

There is no information about an overdose of the drug in the form of a cream or eye ointment.

Interaction

No significant drug interactions were observed with the use of the drug.
Acyclovir is excreted in the urine unchanged due to tubular secretion. All funds with a similar elimination method can increase the concentration of acyclovir in the blood.
Caution is advisable to combine intravenous administration of Zovirax with funds that disrupt the work of the kidneys (Cyclosporine, Tacrolimus and others).

Terms of sale

The cream is dispensed without a prescription. Other forms of the drug can be purchased only on prescription.

Storage conditions

Store at room temperature in a dry place. Keep away from children.
Shelf life - 5 years.

special instructions

Patients taking the drug orally in large doses should consume sufficient fluid.
The appearance of burning immediately after application of ophthalmic ointment, which usually passes spontaneously, is not excluded.
During the period of drug therapy, contact lenses are not allowed to wear.
In order to maximize the therapeutic effect, it is necessary to start using the drug even with the initial symptoms of the disease (tingling, itching, burning, redness).
If the signs of herpes lips are pronounced, it is necessary to consult a doctor.
In the treatment of genital herpes, it is advised to refrain from sexual intercourse or use condoms, since the use of acyclovir does not prevent sexual transmission of the disease.
The cream is not advised to be applied to the mucous membranes of the mouth and eyes due to the possible appearance of local inflammation.
Patients with immunodeficiency in the treatment of any infectious lesions should adhere to the recommendations of the attending physician.
In persons with herpetic encephalitis, taking Zovirax in large doses, it is necessary to constantly monitor the work of the kidneys.
The finished solution of the preparation has a pH equal to 11, so it is forbidden to use it inside.

Children

Eye Ointment and Cream Zovirax

Eye ointment and Zovirax cream are used in the aunt by the same scheme and at the same doses as adults (described in the section "Instructions for use of Zovirax").

Newborns

In newborns, dosages are calculated based on body weight.
In the treatment of infectious lesions associated with the herpes simplex virus, in newborns, the recommended dose of the drug is calculated according to the 10 mg / kg weight regimen three times a day. The duration of treatment is usually 10 days.
To use the cream and ointment, age limits are not specified in the instructions.

Zovirax during pregnancy and lactation

It is permitted to use tablets, injections, cream and ointment Zovirax during pregnancy and lactation with caution, if there are strict indications and after assessing the benefit / risk ratio for the fetus and the mother.
According to the research, there was no increase in the number of congenital diseases in children whose mothers took Zovirax during pregnancy when compared with children whose mothers did not take the drug.

Reviews about Zovirax

Almost all reviews about Zovirax ointments and reviews of other forms of release of this drug perfectly characterize the therapeutic effectiveness of the drug. Most often use Zovirax from herpes. Reports of adverse effects and ineffectiveness of the drug are extremely rare. The greatest dissatisfaction of patients is the high price of the drug.