Famvir tabs 125mg #10

User manual for Famvir

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Composition

The active ingredient of the drug Famvir famciclovir. Additional components: hydroxypropyl cellulose, sodium starch glycolate, lactose anhydrous, magnesium stearate.
The shell consists of gipromelloza, polyethylene glycol 4000, titanium dioxide, polyethylene glycol 6000.

Form release

The drug is sold in tablets. In the same package can be 1-4 blister. In one blister can be from 3 to 10 tablets.

Pharmacological action

This drug has an antiviral effect.

Pharmacodynamics and pharmacokinetics

After oral administration, the active substance of the drug is converted to penciclovir, which has an impact on the cytomegalovirus, as well as the Epstein-Barr virus and human herpes viruses. It falls into the infected areas of the body, where it turns into a monophosphate, turning into a triphosphate. Being in infected cells for more than 12 hours, it prevents replication of viral DNA. Its content in cells, where there is no virus, is minimal, so they do not affect triphosphate.
Potenzieller acts against acyclovir resistant strains of Herpes simplex with changed DNA polymerase.
The drug reduces the manifestation and duration of postherpetic neuralgia in people with herpes zoster.
Its bioavailability is 77%. The maximum drug concentration is achieved in approximately 45 minutes. Penciclovir is characterized by the degree of connection with plasma proteins by less than 20%. Half-life time of plasma up to 2 hours. The active substance of the drug is excreted mainly in the urine.

Indications for use

This drug is prescribed by a doctor for:
varicella;
super-aggressive therapy for recurrent infection associated with herpes;
primary infection with herpes simplex virus;
shingles;
ocular herpes;
viral infections due to Herpes simplex and Varicella zoster;
post-herpetic neuralgia;
exacerbation of infections associated with herpes.

Contraindications

The drug can not be used in:
special sensitivity to penciclovir and drug constituents;
viral infectious diseases in children;
pregnancies;
breast feeding.

Side effect

Adverse reactions when using the drug appear rarely. Sometimes patients complain of headache or nausea, but these manifestations are poorly expressed. In addition, the following possible side effects are known:
hematopoietic system-thrombocytopenia;
digestive system-vomiting, jaundice;
Allergy-urticaria, severe reactions to the skin;
Central nervous system-confusion, drowsiness, dizziness, hallucinations;
skin-rash, itching.

Instructions for use Famvir (Method and dosage)

Instructions Famvir reports that the tablets should be taken orally. The time of their admission does not depend on food, they cannot be chewed, but you can drink water. Dosages depend on the pathological condition and other factors.
An infection provoked by the virus Varicella zoster (patient's normal immunity), it is recommended to take 3 times a day 250 mg 2 times a day 500 mg or 1 time per day, 750 mg With postherpetic neuralgia given 3 times a day 250-500 mg. When eye herpes is prescribed 3 times a day, 500 mg. In the infection triggered by the Herpes simplex 1 and 2 type (in this case the patient has reduced immunity), take 2 times a day 500 mg. Instructions for use Famvir informs that in all four cases the course of application is designed for a week. It is advisable to start therapy immediately after the first symptoms of the disease.
In cases of infections caused by Varicella zoster virus, patients with reduced immunity are given 500 mg of the drug 3 times/day for 10 days.
With infections triggered by the virus Herpes simplex 1 and 2 type (in this case the patient has a normal immune system), give 3 times/day at 250 mg in recurrent chronic infection patients in adulthood prescribe the medicine 2 times/day in a dosage of 125 mg. In both cases, it is desirable to start therapy at the first symptoms of the disease, the medicine used for five days.
In the case of recurring herpes infection take 2 times/day 250 mg Course of therapy prescribed individually in each case depending on the severity of the disease.
In order to assess possible changes, it is recommended to discontinue the use of tablets once a year.
Effective dosage for HIV-infected patients is usually 2 times / day at 500 mg.
Daily doses in accordance with CC (ml / min / 1.73 m2) can be as follows:
Infections caused by the virus Varicella zoster, in terms of QC:
greater than or equal to 40 – 3 times 250/500 mg;
30 to 39 2 or 3 times 250 mg;
from 10 to 29-2 or 3 times to 125 mg.
Infection triggered by the Herpes simplex virus (thus the patient's immunity is reduced), when QC indicators:
greater than or equal to 40 – 2 times 500 mg;
30 to 39 – 2 times 250 mg;
from 10 to 29 - 2 times 125 mg.
Infection triggered by the Herpes simplex virus (in this case the patient has a normal immune system):
the first episode-the CC greater than or equal to 30 - 3 times 250 mg; CC indicators from 10 to 29 - 3 times 125 mg;
recurrent infection-CC values are greater than or equal to 10 – 3 times 125 mg.
Super-aggressive therapy of recurrent herpetic infection, in the parameters of CC:
greater than or equal to 30 – 2 times 250 mg;
from 10 to 29 - 2 times 125 mg.
People with renal failure who are on hemodialysis need to take the medicine immediately after hemodialysis. We recommend taking 125 mg for genital herpes 250 mg for herpes zoster.

Overdose

In case of high dosage, acute renal failure may develop in case of chronic renal failure.
In case of overdose, symptomatic and supportive treatment is carried out. The active substance of the drug can be derived by hemodialysis. The content of famciclovir decreases by 75% within four hours.

Interaction

Clinically significant interaction Famciclovir with other drugs is not observed. Drugs that block tubular secretion may increase the plasma concentration of penciclovir.

Terms of sale

You can buy Famvir without a prescription.

Storage conditions

The optimal temperature is up to 30 ° C. the Medicine should be stored in a place inaccessible to young children.
Shelf life - three years.

What is better — he needs therapy with valtrex, or Famvir?

Often, consultation with a doctor people ask what the best he needs therapy with valtrex, or Famvir. Experts do not give an unambiguous answer. In fact, both drugs have similar effects. However, the cost of Famvir is higher. So patients who want to save money, often choose he needs therapy with valtrex, because the price is much less.

Reviews on Famvir

Reviews on Famvir you can find different. Someone enthusiastically talks about how this tool helped him, but not rare and cases when the course of the drug was ineffective. In addition, some reviews of Famvir report adverse reactions in the form of allergies.