Octolipen tabs 600mg #30

Octolipen instruction for use

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Composition

The active substance of the preparation is thioctic acid (α-lipoic acid).
Auxiliary components in capsules and tablets: calcium hydrophosphate dihydrate, magnesium stearate, silicon dioxide colloid, gelatin medical, quinoline yellow E 104, titanium dioxide E 171, dye sunset yellow E 110.
Auxiliary components in the concentrate for the preparation of a solution for infusions: ethylenediamine, water for injection, disodium edetate.

Form of issue

Octolipen is available in capsules and tablets coated with film membranes. Another form of release is a concentrate for the preparation of a solution for infusions.

pharmachologic effect

Neuroprotective, hypoglycemic, hypocholesterolemic, hepatoprotective and hypolipidemic.

Pharmacodynamics and pharmacokinetics

The main active substance of the drug is an endogenous antioxidant.
Thioctic acid reduces the level of glucose in the blood, helps to overcome insulin resistance, and also increases the glycogen content in the liver. Close on the nature of the action to the vitamins of group B. It takes part in lipid and carbohydrate metabolism, improves liver function, activates the exchange of cholesterol.
In addition, thioctic acid acts as a hepatoprotective, hypocholesterolemic, hypolipidemic and hypoglycemic agent. It improves the trophism of neurons, reduces the manifestation of alcoholic and diabetic polyneuropathy, activates axonal conductivity.
Concentrate for the preparation of the solution with internal administration reaches a maximum concentration of 25-38 μg / ml. The volume of distribution is approximately 450 ml / kg.
Capsules and tablets are ingested in a short time during ingestion. If consumed with food, absorption decreases. Bioavailability is 30-60%. The maximum concentration in the blood is reached in 25-60 minutes.
Regardless of the dosage form, the drug is processed in the liver by conjugation and oxidation of the side chain. It is excreted through the kidneys by about 80-90%. Half-life is 20-50 minutes.

Indications for the use of Octolipen

Indications for use of Octolipen in the form of capsules of 300 and 600 mg:
    polyneuropathy of diabetic genesis;
    polyneuropathy of alcoholic genesis.
Indications for use of Octolipen in the form of a solution for infusions of 12 and 25 mg:
    fatty degeneration of the liver;
    chronic hepatitis;
    intoxication;
    hyperlipidemia;
    cirrhosis of the liver;
    hepatitis A;
    Poisoning with pale toadstool.

Contraindications

Contraindications to the use of the drug are as follows:
    hypersensitivity to the components of the drug;
    pregnancy;
    lactation period;
    childhood.

Side effects

When using this medication, there may be the following side effects:
    the appearance of allergic reactions (even anaphylactic shock is possible);
    from the side of the digestive tract, nausea, heartburn, vomiting;
    symptoms of hypoglycemia.

Octolipen - instructions for use

For those who are prescribed capsules or Octolipen tablets, the instructions for use include taking an empty stomach in the morning half an hour before eating a daily dose. Simultaneous eating reduces the effectiveness of the drug. Chew and grind tablets and capsules are also not recommended.
The daily dose, which provides instructions for the use of Octolipen - 600 mg (1 tablet or 2 capsules). However, the duration of the course and the final dosage is determined by the doctor.
To increase the effectiveness of the drug in some cases, the first 2-4 weeks is prescribed using a concentrate for the preparation of infusions, after which capsules or tablets are used in standard doses.
To prepare the solution used 1-2 ampoules, which are diluted in 50-250 ml of 0.9% sodium chloride solution. After preparation it is injected intravenously. The standard dose is 300-600 mg per day.
The drug is sensitive to light, so you need to get the ampoules just before use. At this time, it is also desirable to protect the bottle from sunlight. The prepared solution should be stored in a well protected from light place and not longer than 6 hours after preparation.

Overdose

Due to an overdose of the medication, headache, vomiting and nausea may occur. Treatment is symptomatic.

Interaction

The drug stimulates hypoglycemic action of insulin and antidiabetics, which are taken orally. That is why when combining these drugs, you need to constantly monitor the glucose content in the blood plasma and adjust the dosage of antidiabetics if necessary.
In addition, you should observe a half-hour interval between taking Octolipen and dairy products, as well as preparations with iron, calcium and magnesium. It is desirable in this case to take Octolipen in the morning, and funds with iron, magnesium and calcium - in the evening. In addition, this drug reduces the effect of cisplatin when used at the same time.
The effectiveness of the Octolipen itself reduces ethyl alcohol. So during the course of this drug is recommended to refrain from drinking alcohol.
Thioctic acid also activates the anti-inflammatory properties of glucocorticosteroid agents.

Storage conditions

Keep the drug in a dry, well protected from sunlight penetration place, not accessible to children. The storage temperature is 15-25 ° C.
The shelf life of the Octolipen is 2 years.

Reviews about Octolipen

Reviews of the Octolipen are usually positive. Many patients note its apparent effectiveness. Sometimes it is offered in pharmacies in exchange for a more expensive Berlin. Reviews of the Octolipen at the same time say that the effect of the drug is as effective as its analogue.