Thiogamma solution 1.2% 50ml

Thiogamma solution instruction for use

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Composition

Thiogamma concentrate for preparing the solution for infusion in the form of a clear solution of yellowish-green color.
- thioctic acid meglumine salt 58.385 mg / 1 ml, 1167.7 mg / 1 amp.,
that sootv. the content of thioctic acid 30 mg / 1 ml, 600 mg / 1 amp.
Excipients: meglumine, macrogol 300, water d / and.
Thiogamma solution for infusions of light yellow or yellowish-green color, transparent.
- thioctic acid meglumine salt 23.354 mg / 1 ml, 1167.7 mg / 1 amp.,
that sootv. the content of thioctic acid 12 mg / 1 ml, 600 mg / 1 amp.
Excipients: meglumine, macrogol 300, water d / and.

pharmachologic effect

Thiogamma solution is a drug that regulates metabolism. Thioctic (a-lipoic) acid is synthesized in the body and acts as a coenzyme in the oxidative decarboxylation of alpha-keto acids. Helps reduce blood glucose and increase glycogen content in the liver.
Thioctic acid is similar in pharmacological properties to B vitamins.

Thiogamma solution, indications

Diabetic polyneuropathy.

Contraindications

   - hypersensitivity to the drug;
   - pregnancy;
   - breastfeeding period.
Clinical data on the use of Thiogamma solution in children are not available, so children can not prescribe the drug.

Dosage and administration

The drug Thiogamma solution administered in / in a dose of 600 mg / day (1 amp. 20 ml of 3% solution or 1 vial. 50 ml of 1.2% solution).
At the beginning of the course of treatment (within 2-4 weeks), the drug is recommended to be administered IV. Then you can continue taking the drug inside.

Use during pregnancy and lactation

The drug Thiogamma solution is contraindicated for use in pregnancy. If necessary, the use of the drug during lactation should stop breastfeeding.
In experimental animal studies, no teratogenic effect of thioctic acid was detected. No similar human studies have been conducted.
There is no data on the removal of thioctic acid in breast milk.

Side effects

From the side of the central nervous system: rarely (after i / v administration of the drug) - convulsions, diplopia; with the rapid introduction - increased intracranial pressure.
On the part of the blood coagulation system: after intravenous administration of the drug - hemorrhagic rash, thrombophlebitis, point hemorrhages in the mucous membranes and skin.
Allergic reactions: urticaria, systemic reactions (up to anaphylactic shock).
Other: possible development of hypoglycemia (due to improved glucose uptake); after a quick on / in the introduction - difficulty breathing (passes on its own).

special instructions

Patients taking the drug Thiogamma solution, should refrain from alcohol.
During the period of treatment with the drug Thiogamma solution, especially at the beginning of therapy, it is necessary to monitor the level of glucose in the blood. In some cases, it may be necessary to adjust the dose of hypoglycemic drugs.

Interaction

When combined, Thiogamma solution in the form of a solution for injection reduces the effectiveness of cisplatin.
With the simultaneous use of Thiogamma solution enhances the action of insulin and oral hypoglycemic agents.
When taken simultaneously with ethanol, the therapeutic efficacy of thioctic acid may decrease.

Pharmaceutical Interaction

In vitro, thioctic acid reacts with complex metal ions (for example, cisplatin), and also forms moderately soluble complex compounds with sugar molecules. Therefore, the infusion solution is incompatible with glucose solution, Ringer's solution and with solutions that can react with SH-groups or disulfide bridges.

Overdose

Symptoms: nausea, vomiting, headache.
Treatment: conduct symptomatic therapy. There is no specific antidote.

Storage conditions

Store in a dark place at a temperature of from 15 ° to 25 ° C.

Terms of sell

You can buy Thiogamma solution without a prescription.