Artradol powder 100mg #10

User manual for Artradol

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Composition

The drug has 100 mg of chondroitin sodium sulfate.

Form of issue

The drug is available in the form of a lyophilizate, which is used to prepare a solution for intramuscular injection. Ampoules contain 2 ml of the drug. The cardboard box contains one cardboard holder, containing 10 ampoules or two plastic pallets, each containing 5 ampoules.
Lyophilizate is a white or yellowish porous mass that is compacted into tablets.
Also, an ointment of Artradol 5% is used, which is applied externally. It is sold in cans of glass to 30 grams, packed in a pack of cardboard.

pharmachologic effect

The active substance chondroitin sulfate is the main component of proteoglycans, which together with collagen fibers form a cartilage matrix. The drug has chondroprotective properties. It has the ability to reduce the activity of enzymes, which provoke the processes of degradation of the articular cartilage. Also, under its influence, the production of chondrocytes by proteoglycans is stimulated and metabolic processes in cartilage and subchondral bone are intensified. Artradol promotes the exchange of calcium and phosphorus in the cartilaginous tissue, promotes its active regeneration, takes part in the formation of cartilaginous and bone tissue.
The medicine has analgesic and anti-inflammatory properties.
Under the influence of the drug decreases the release of mediators of inflammatory processes, reduces the level of secretion of prostaglandin E2 and leukotriene B4.
Thus, Artradol activates the resistance to restorative processes in the cartilaginous surfaces of the joints, normalizes the production of joint fluid, does not allow the collapse of connective tissue. Due to this effect, the level of pain is reduced, the mobility of the joints improves.
Due to structural similarity with heparin, the drug is potentially capable of preventing the appearance of fibrin clots in the subchondral and synovial microcirculatory bed.

Pharmacodynamics and pharmacokinetics

Absorption and distribution of chondroitin sulfate occurs when administered intramuscularly easily. Half an hour after the introduction, the drug can already be detected in the blood in high concentrations, after 15 minutes the drug is found in the synovial fluid. The maximum concentration is noted one hour after the administration, for two days the active substance content gradually decreases. Artradol mainly accumulates in the cartilaginous tissue.
The drug is excreted through the kidneys for one day.

Indications for use

Pricks of Artradol are prescribed for the following diseases:
    primary arthrosis;
    degenerative-dystrophic diseases of the spine, joints;
    osteoarthritis, in which large joints are affected;
    intervertebral osteochondrosis.

Contraindications

The drug is not used in the following cases:
    high sensitivity to its components;
    the child's age of the patient.
Very carefully, the remedy is given to people who are prone to bleeding; patients with thrombophlebitis; during pregnancy and lactation.

Side effects

When using the drug, such side effects are rarely noted:
    allergic manifestations;
    hemorrhages in the place where the injection was conducted.

Instructions for use (Method and dosage)

The instruction for Artradol is as follows: the injections are administered to the patient intramuscularly, the agent is given 100 mg every other day. If the drug is well tolerated, then after the third injection, the dose may be increased to 200 mg. A total of 25 to 35 injections are prescribed for treatment. Repeat the course of therapy can be in six months. How long should the repeated course of therapy continue, the attending physician determines in each individual case.
Instructions for the use of Artradol provide that, before the direct administration, the contents of the ampoule must be dissolved in 1 ml of water for injection.

Overdose

There are no data on overdose by the drug.

Interaction

If Artradol is taken simultaneously with indirect antiplatelet agents, anticoagulants, fibrinolytic agents, the effect on the body of these drugs may be intensified. In this case, it is necessary to monitor the coagulability of the blood.

Storage conditions

Store Artradol in a dark place, and the temperature should not exceed 25 ° C. It is necessary to protect the remedy from children.
You can store drugs for 3 years.

Children

For the treatment of children is not applied, because there is not enough clinical data on its effect.

In pregnancy and lactation

Pregnant women and lactating mothers are prescribed with caution.

Reviews of Artradol

At forums, reviews about Artradol are relatively common. In particular, the reviews of patients with spine ailments, etc. indicate that injections significantly reduce the pain syndrome already during the first course of therapy. According to the patients, the drug effectively reduces edema in patients with osteochondrosis, joint arthrosis. Positive in general, and reviews of doctors, which noted that the drug works most effectively, if you use it strictly according to the scheme and in the dose that the specialist appointed.
In the reviews, very little is said about the side effects of the remedy. Sometimes people who have been treated with the drug mention minor allergic reactions, as well as the appearance of hemorrhages in the places where the injection was done.