Diprospan 2mg + 5mg/ml 1ml amps №1

Diprospan user instruction

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Composition

The drug injections include betamethasone dipropionate, equivalent to pure betamethasone in the amount of 2 mg and 5 mg.
Additional components are sodium edetate, methylparahydroxybenzoate, hydrochloric acid, injection water, sodium phosphate, benzyl alcohol, nipagine, sodium chloride, polysorbate 80, nipazole, sodium carboxymethylcellulose, polyethylene glycol 4000, propyl parahydroxybenzoate and trilon B.

Form of issue

Supposium for injection in ampoules or disposable syringes.

pharmachologic effect

Glucocorticosteroid. The active ingredient is betamethasone. The mechanism of action is based on inhibition of the release of interleukins 1 and 2, interferon-gamma from macrophages and lymphocytes. The drug has anti-allergic, anti-shock, anti-inflammatory, immunosuppressive, antitoxic and desensitizing effects. Diprospan does not affect the circulating beta-endorphin index, but it inhibits the release of beta-lipotropin and ACTH from the pituitary gland.
Hormonal or not? The drug is hormonal.

Pharmacodynamics and pharmacokinetics

The drug is able to inhibit the secretion of FSH and TSH. The drug Diprospan stimulates the production of erythropoietins, increases the number of erythrocytes, reduces the number of eosinophils and lymphocytes, and increases the excitability of the central nervous system. When the active component interacts with specific, cytoplasmic receptors, a complex is formed that is able to penetrate inside the cell, into its nucleus and stimulate the process of mRNA synthesis (it induces the formation of lipocortin and other proteins that mediate cellular effects). Lipocortin inhibits the release of arachidonic acid, inhibits phospholipase A2, inhibits the synthesis of leukotrienes, prostaglandins and endoperoxides, which take an active part in inflammatory processes, in the formation of an allergic response. Under the influence of diprospan, the amount of protein in the blood plasma decreases due to globulins, but the albumin / globulin ratio increases, albumin production in the tissues of the kidneys and liver increases, and protein catabolism in muscle tissues increases.
Influence of the drug Diprospan on lipid metabolism: redistribution of fat (fat deposits are localized mainly in the abdomen, face, shoulder girdle), increasing the synthesis of triglycerides and higher fatty acids, the formation of hypercholesterolemia. Influence of the drug on carbohydrate metabolism: activation of phosphoenolpyruvate carboxylase, enhancement of aminotransferase synthesis (leading to activation of gluconeogenesis), increased absorption of carbohydrates from the digestive tract, increased activity of glucose-6-phosphatase (increases the flow of glucose into the blood from the liver).

Influence of the drug on water-electrolyte metabolism: stimulation of elimination of potassium ions, retention of water and sodium ions in the body, "washing away" of calcium ions from the bone system, reducing absorption of calcium ions from the digestive tract, increasing excretion of calcium ions by the renal system. Anti-inflammatory effect is achieved due to inhibition of the release of inflammatory mediators by eosinophils; on the account of a decrease in the number of mast cells (they produce hyaluronic acid), inducing lipocortin formation, by stabilizing the membranes of organelles (lysosomal organelles are especially important), stabilizing cell membranes, by reducing the permeability of capillaries.
Antiallergic effect is achieved due to the suppression of secretion and the process of synthesizing mediators of allergy, inhibition of the process of antibody formation, by changing the immune response of the organism, reducing sensitivity to allergic mediators of effector cells, by inhibiting the release of biologically active substances and histamine from mast cells, T-lymphocytes, B lymphocytes.
With COPD, the drug Diprospan prevents and inhibits the development of swelling of the mucous membranes, inhibits the course of inflammatory processes, slows the deposition of circulating immune complexes in the mucous membranes of the bronchial tree, reduces the rate of eosinophilic infiltration of the submucosal layer in the epithelium of the bronchial tree. The drug slows down the process of desquamation and erosion of the mucous membranes. By reducing production and suppressing the production of mucus, its viscosity decreases. Antitoxic and anti-shock effects are achieved by increasing blood pressure by vasoconstriction, increasing the level of catecholamines circulating in the blood and restoring the sensitivity of adrenoreceptors to them. The effect is achieved through the activation of hepatic enzymes, which take part in the metabolism of xenobiotics and endobiotics, by reducing the permeability of the walls of the vessels, as well as through membrane-protective action.
Immunodepressive effect is provided by a decrease in the release rate of cytokines (interferon gamma, interleukin-1,2) from macrophages and lymphocytes. The drug suppresses the secretion and synthesis of ACTH, the second slows down the process of synthesizing endogenous glucocorticosteroids. Under the influence of medication, the probability of scars formation decreases due to inhibition of the rate of connective tissue reaction in the course of inflammation. Buy Diprospan can be in the form of suspensions and solution for injection.

Indications for the use of Diprospan

What is the medicine for Diprospan?

Indications for the use of Diprospan injections are as follows: medication is prescribed for shock (toxic, cardiogenic, surgical, burn, traumatic), with anaphylactoid reactions, hemotransfusion shock, allergic reactions, anaphylactic shock, asthmatic status, severe bronchial asthma, radiotherapy, after surgical interventions), with acute adrenal insufficiency. Also indications for use are: systemic pathology of connective tissue (rheumatoid arthritis, SLE), poisoning with cauterizing fluids (prevention of scar formation and reduction of inflammation), hepatic coma, acute hepatitis, thyrotoxic crisis. Often blockades are placed with Diprospan.

Contraindications to diprospan

Instruction for the use of Diprospan does not recommend the appointment of intra-articular medication with pathologic bleeding, with periarticular infections, with septic and infectious joint damage, with a pronounced form of periarticular osteoporosis, with common infectious diseases, with intraarticular bone fracture, after arthroplasty, with severe bone destruction, dry "joint, with osteoarthritis without symptoms of synovitis, with joint instability after arthritis, with aseptic necrosis of the epiphysic in the bones that form the joint.
For fungal, infectious, parasitic and bacterial lesions, with herpes zoster, herpes simplex, tuberculosis (latent or active form), with strongyloidiasis, amoebiasis, measles, chicken pox, systemic mycosis Diprospan is used with caution.
In severe infectious diseases, the drug can be administered only with simultaneous specific therapy. The drug is not used for diseases of the digestive tract: diverticulitis, peptic ulcer, gastritis, esophagitis, intestinal anastomosis, peptic ulcer, ulcerative colitis. Betamethasone is not prescribed in the post-vaccination period, with lymphadenitis after the BCG vaccine. The drug is contraindicated in arterial hypertension, diabetes mellitus, hypothyroidism, with recently transferred myocardial infarction, with decompensated form of CHF, with Itenko-Cushing's disease, thyrotoxicosis, nephrourolythiasis, severe liver and kidney pathology, poliomyelitis, obesity, myasthenia gravis , systemic osteoporosis, hypoalbuminemia, acute psychosis, glaucoma (closed and open-form), with pregnancy, during lactation.
Contraindication to diprospan is also increased sensitivity to betamethasone.

Side effects of Diprospan

Side effects from the use of the drug Diprospan depend on the possibility of observing the circadian regimen of treatment, the dosage and duration of the drug. Endocrine system: manifestation of latent diabetes mellitus, steroid diabetes, delay in sexual development in children, Itenko-Cushing syndrome (myasthenia, amenorrhea, dysmenorrhea, stria, hirsutism, pituitary-type obesity, lunate face, increased blood pressure, hirsutism). Digestive tract: anorexia, steroid ulcer of the gastrointestinal system, pancreatitis, vomiting, nausea, flatulence, hiccough, increased level of enzymes in the hepatic system. Cardiovascular system: formation of thromboses, hypercoagulation, increased severity of CHF, bradycardia, arrhythmia. Nervous system: convulsions, headaches, pseudotumor of the cerebellum, manic-depressive psychosis, euphoria, disorientation in space, delirium, vertigo, dizziness, insomnia, anxiety, nervousness, increased intracranial pressure, paranoia, depression.
Description of side effects of Diprospana on the sensory organs: posterior subcapsular cataract, sudden loss of vision, exophthalmos, trophic changes in the cornea, increased intraocular pressure. Metabolism: increased sweating, increased protein breakdown, negative nitrogen balance, weight gain, hypocalcemia, increased excretion of calcium ions from the body. Musculoskeletal system: osteoporosis, atrophy and muscle loss, steroid myopathy, muscle tendon rupture, slowing ossification and growth of the osseous system in children as a result of premature closure of epiphyseal growth zones. Skin: a tendency to develop candidiasis and pyoderma, steroid acne, impaired pigmentation, thinning of the skin, the formation of ecchymoses and petechia, slowing healing of wounds. Possible the formation of an allergic response, leukocyturia. With intravenous administration, cramps, "tides" of blood flow to the face, arrhythmias are possible.

Diprospan injections, instructions for use

The dosage regimen of betamethasone and the method of administration are selected depending on the nature and severity of the underlying disease.
According to the instructions for use of Diprospan, the infusion solution is diluted in a 0.9% sodium chloride solution or in a dextrose solution before administration. You can enter only a freshly prepared solution. Injections by Diprospan are made intramuscularly in a dose of 4-8 mg in severe pathology.
Periarticular and intraarticular injection of the drug is carried out in very large joints in a dose of 4-8 mg. A stab in the joint directly allows you to achieve a more effective effect on the inflammatory process in it. Injections are made and in the knee, however such injections should be entrusted to doctors, since this is a complicated process.
With skin diseases, the drug is injected into the wound or intradermally at a dose of 0.2 ml / square centimeter.
When bursitis is performed local infiltration: 1-2 mg. If necessary, the drug can be administered subconjunctivally in a dose of 2 mg.
When using a medication, it is very important to take into account contraindications.
The agent is not available in the form of ointments and tablets.

How many times can I stab and how often?

It is better to consult a doctor who will choose the dose that is necessary for you. Uncontrolled use of the drug adversely affects the condition of the body.

Overdose

The annotation indicates that the overdose is manifested by a sleep disorder, vomiting, nausea, depression, arousal, euphoria. Prolonged use in large quantities causes the formation of secondary adrenal insufficiency, increased blood pressure, fluid retention in the body, osteoporosis. Requires the use of aminoglutetimide, antacids, correction of electrolyte balance.

Interaction

Diprospan reduces the effectiveness of anticoagulants, insulin, hypotensive drugs, oral hypoglycemic medications. The drug weakens the activity of vaccines, the action of diuretics. The use of barbiturates, phenytoin, rifampicin weakens the effect of the drug. The risk of side effects increases with treatment with antipsychotic drugs, estrogens, androgens, NSAIDs, immunosuppressants, ritodrin, digitalis glycosides, nitrates, tricyclic antidepressants. Diprospan increases the severity of hepatotoxic effects of paracetamol. Inhibitors of carbonic anhydrase and amphotericin B increase the risk of osteoporosis. The drug slows the metabolism of cyclosporine and increases its toxicity, increases the metabolism of mexiletine, isoniazid, increases the concentration of folic acid. The drug reduces the effectiveness of growth hormone.

Storage conditions

In a dark place inaccessible to children at a temperature of 2-25 degrees Celsius. Do not freeze. Shake before use.

Shelf life

Not more than 3 years.

special instructions

Diprospan can be mixed in solutions of local anesthetics in equal amounts. It is inadmissible to use medicament in the therapy of hyaline-membrane disease in newborn children. The drug can not be injected into the intervertebral spaces, into infected areas and unstable joints. Before the start of treatment, it is necessary to conduct the examination: general blood test, blood glucose level, electrolytes. With concomitant tuberculosis, sepsis, intercurrent infections, antibiotics are simultaneously administered. Reviews of the drug indicate a high effectiveness of the drug, with all recommendations. It is important to consider that in patients with hypothyroidism, the clearance of glucocorticosteroids decreases, with thyrotoxicosis the reverse effect is recorded.
In Wikipedia, there is no article on the medicine.

Compatibility with alcohol

It is better to stop drinking alcohol, as its use increases the side effects of the drug.

Reviews about Diprospan

Good reviews about Diprospan injections are very common. The drug is mentioned as a powerful anti-inflammatory and antiallergic agent, which quickly removes all unpleasant symptoms.
Quickly and qualitatively with psoriasis, Diprospan medication is being handled, all of them are mostly of good opinion. The medication also helps with eczema, the use of the drug has positive reviews for arthrosis. However, even if the medicine is effective enough, it has sometimes manifested side effects, such as, for example, weight gain and dyspnoea.

Diprospan for allergies, doctors reviews

This remedy should only be used as directed by the doctor, and in no case should they be abused. The medicine stops an allergic attack, however, the use of the drug has an action that poison the body.