Dolobene gel 90gr
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Dolobene user manualReed more and buy Dolobene gel on this pageCompositionThe gel contains 3 active ingredients: Dexpanthenol; Heparin sodium; Dimethyl sulfoxide.In 100 grams o..
Dolobene user manual
Reed more and buy Dolobene gel on this page
The gel contains 3 active ingredients:
In 100 grams of active ingredients are contained in an amount of 2.5 g / 50 thousand IU / 16.66 g.
citronella oil (type of lemongrass);
mountain pine oil;
Form of issue
Gel Dolobene has a yellowish shade. Produced in special tubes made of aluminum 50/100 grams.
Multicomponent means of external use. The pronounced therapeutic effect is achieved by the complex action of the three active components.
Dimethyl sulfoxide has anti-edema, anti-inflammatory and local anesthetic effects. Anti-inflammatory effect is achieved due to inactivation of various hydroxyl radicals, which are produced in large volumes during the inflammatory process. On the tissue radicals are destructive. Local anesthetic effect is provided by delayed carrying out of painful (nociceptive) impulses in peripherally located neurons. The anti-edema effect is achieved by improving the metabolic processes in the subcutaneous fat in the gel application area. The anti-edema effect is also achieved due to hygroscopicity of Dimethyl Sulfoxide. The active component easily passes through the skin and other biological membranes, contributing to a more pronounced, deep penetration into the tissues of the drugs used together.
Heparin has an anti-inflammatory effect, improves the regenerative capacity of connective tissue. The effect is developed due to the suppression of the activity of the enzyme Hyaluronidase. For Heparin, an antithrombotic effect is characteristic, which is dose-dependent. The active component increases the inhibitory effect of antithrombin-3 on the activation of thrombin and prothrombin. The degree of penetration of the medication through healthy skin is dose-dependent and is recorded at a dose of more than 300 IU per gram.
Dexpanthenol is able to transform into a vitamin B group - Pantothenic acid for topical use. The effectiveness of the component is fully comparable to that of Pantothenic acid. The latter is part of coenzyme A and takes an active part with anabolic reactions, catabolic processes in tissues. The regenerative effect in damaged tissues is achieved by improving the processes of epithelization and granulation.
Pharmacodynamics and pharmacokinetics
The physiological concentration of one of the active substances of Dimethyl Sulfoxide is normal in plasma of 40 ng / ml. After 6 hours after the application of the gel, C (max) is 120 ng / ml and can be stored up to 12 hours after application. The concentration of the dimethyl sulphoxide component reaches a physiological index of 40 ng / ml after 60 hours after the application of the drug. If the gel is applied 3 times a day for 1 gram for 5 days, the average content at the site of application will be 3 mg / g on the skin, 0.8 μg / g in the synovial fluid and 7-10 μg / ml in the synovial membrane in the area synovial joint and in the underlying muscular tissues. With external application, one of the active components of Heparin practically does not enter the systemic circulation. Dexapanthenol is converted to Pantothenic acid for external use. Good absorption of dexpanthenol has been experimentally proven.
The period T1 \ 2 of the active substance of Dimethyl Sulfoxide is 11-14 hours. During the first day 12-25% of absorbed Dimethyl Sulfoxide is excreted; during the week - 37-48% in the form of a metabolite of Dimethylsulfone and unchanged through the renal system. After 6-12 hours through the pulmonary system, 3.5-6% of total dimethyl sulfoxide is deduced.
Indications, use of ointment (from which ointment)
traumatic injuries (closed forms);
hematomas and inflammatory processes in soft tissues, tendons and their vaginas;
swellings of soft tissues;
periarthritis of the shoulder joint;
traumatic joint damage, accompanied by stretching of tendons and ligaments;
shoulder epicondylitis ("tennis player's elbow");
bursitis (inflammatory processes with articular bags);
Tendovaginitis (inflammatory processes in the tendon sheaths);
tendonitis (inflammatory processes in tendons).
open wound injuries in the area of application of the gel;
marked pathology of the liver system;
pathology of the heart, vascular system;
marked changes in the functioning of the renal system;
restriction on age - up to 5 years;
Local reactions (disappear themselves after drug discontinuation):
redness of the skin (mild, moderately pronounced);
itching of the skin at the site of application of the gel.
edema of Quincke;
Other negative reactions:
change in taste perception;
the smell of garlic from the mouth (occurs as a result of the metabolism of dimethylsulfoxide with the formation of dimethyl sulfide);
Gel Dolobene, instructions for use (Method and dosage)
Ointment is applied to the skin over the affected area with a thin layer 2-4 times a day. If it is necessary to apply the dressing, the gel is left for several minutes after application for greater absorption and evaporation of Isopropanol. Next, a special sealed bandage is applied.
Instructions for use Dolobene during ionophoresis, phonophoresis
The gel is evenly distributed over the cathode imposition area. Active components Dolobene strengthen the therapeutic effect of ultrasonic waves. The decision on the duration of therapy is made by the doctor, based on the severity of the symptoms of the underlying disease, tolerability.
There are no adequate data for this section from the manufacturer.
With external application, Dolobene ointment can enhance the therapeutic effect of other medicinal medicines by increasing the penetration of active substances. Perhaps the development of peripheral neuropathy with the parallel use of medicines, which includes Sulindak from the group of NSAIDs.
Terms of sale
No prescription form is required.
The gel should be stored in the original packaging (aluminum tubes) at a temperature of up to 25 degrees.
Shelf life - 3 years.
The skin before applying gel Dolobene should be cleaned of other medicines, chemicals and cosmetics. Do not apply medication to the mucous membranes of the nose, eyes, mouth, open wound damage to the skin (postoperative scars, due to irradiation, sunburn).
During treatment, the photosensitivity of the skin is increased, which requires patients to restrict their visits to the solarium and avoid intense sunlight. With the manifestation of various skin reactions, therapy is discontinued. It is not recommended to apply simultaneously with other gels and ointments because of the high absorption of Dimethyl Sulfoxide.
During pregnancy (and lactation)
Pregnancy is an absolute contraindication to the use of the gel due to the lack of adequate clinical studies proving the safety of the medication. One of the components of Dimethyl Sulfoxide is excreted in breast milk, which limits the use of Dolobene in lactation.
Reviews of Dolobene
Reviews about gel Dolobene are mostly positive. Thanks to its multicomponent composition, the drug has a complex effect. A convenient form of release allows you to take the tube with you. Ointment of a pleasant consistency is easily applied to the skin. Of the minuses, patients note the high cost of the drug, the absence of a momentary effect. Most often, the medication is prescribed in traumatology, where the main symptom that worries the patient is pain. Dolobene allows you to remove the edema in bruises and other injuries of the osteoarticular system, to stop the pain syndrome, but it acts gradually.