Ketonal gel 2.5% 100gr

Ketonal gel instruction

You can buy Ketonal gel here

Release form, composition and packaging

Gel for external use 2.5% homogeneous, colorless, transparent.
1 g
ketoprofen 25 mg
Excipients: (carbomer - 20 mg, trolamine (triethanolamine) - 37 mg, ethanol 96% - 285 mg, lavender oil (lavender essential oil) - 0.28 mg, water - 632.72 mg) - 1 g.
50 g - aluminum tubes (1) - cardboard packs.
100 g - aluminum tubes (1) - cardboard packs.

pharmachologic effect

NSAIDs. It has analgesic, anti-inflammatory and anti-edema effect. Inhibits the activity of COX, which leads to inhibition of prostaglandin synthesis. In addition, ketoprofen inhibits lipoxygenase, the synthesis of bradykinin, stabilizes lysosomal membranes and prevents the release of enzymes involved in the inflammatory process.
Ketoprofen does not adversely affect the state of the articular cartilage.

Pharmacokinetics

Suction

Ketoprofen is absorbed very slowly and practically does not accumulate in the body. Bioavailability is 5%.
Ketoprofen penetrates the synovial fluid and reaches therapeutic concentrations there. The concentration of Ketonal gel in the blood plasma is extremely low.

Metabolism and excretion

Ketoprofen is metabolized in the liver to form conjugates, which are mainly excreted in the urine. Ketoprofen is characterized by slow urine excretion.

Pharmacokinetics in special clinical situations

Metabolism of ketoprofen does not depend on the age, the presence of a degree of renal failure or cirrhosis of the liver.

Indications

Symptomatic therapy of painful and inflammatory processes of various origins, including:
- rheumatoid arthritis and periarthritis;
- ankylosing spondylitis (ankylosing spondylitis);
- psoriatic arthritis;
- reactive arthritis (Reiter's syndrome);
- osteoarthritis of various localization;
- tendonitis, bursitis;
- myalgia;
- neuralgia;
- radiculitis;
- injuries of the musculoskeletal system (including sports), bruises of muscles and ligaments, sprains, ligaments and tendons of muscles.

Contraindications

- hypersensitivity to Ketonal gel;
- hypersensitivity to salicylates, tiaprofenic acid or other NSAIDs, to fenofibrate, blockers of UV rays, fragrances;
- violation of the integrity of the skin (eczema, oozing dermatitis, open or infected wound);
- indications of a history of bouts of bronchial asthma caused by taking NSAIDs and salicylates;
- photosensitivity reactions in history;
- exposure to sunlight, incl. indirect sunlight and UV radiation in a tanning bed during the entire period of treatment and another 2 weeks after stopping treatment;
- III trimester of pregnancy;
- children's age up to 15 years.
With care: a violation of the liver and / or kidneys, erosive and ulcerative lesions of the gastrointestinal tract, blood diseases, bronchial asthma, chronic heart failure.

Dosage

For external use.
A small amount of gel (about 3-5 cm) with light rubbing movements is applied with a thin layer on the skin above the lesion 1-2 times / day.
Note that 5 cm of gel corresponds to 100 mg of ketoprofen, 10 cm - 200 mg of ketoprofen. The maximum daily dose when using the gel is 200 mg.
Occlusive dressing is not recommended.
Ketonal gel can be used in combination with other forms of Ketonal (capsules, tablets, rectal suppositories).
The duration of treatment without consulting a doctor should not exceed 14 days.

Side effects of Ketonal gel

Local reactions occur most frequently.
Determination of the frequency of adverse reactions: very often (≥1 / 10), often (≥1 / 100 and <1/10), infrequently (≥1 / 1000 and <1/100), rarely (≥1 / 10 000 and <1 / 1000), very rarely (<10 000).
Allergic reactions: very rarely - angioedema, anaphylaxis.
On the part of the skin and skin appendages: infrequently - erythema, itching, burning, eczema, transient dermatitis of mild severity; rarely - urticaria, rash, photosensitivity, bullous dermatitis, purpura, erythema multiforme, lichenoid dermatitis, skin necrosis, Stevens-Johnson syndrome; very rarely - a single case of severe contact dermatitis (against the background of poor hygiene and insolation), a single case of severe generalized photodermatitis, toxic epidermal necrolysis.
On the part of the respiratory system: very rarely - asthma attacks (as a variant of an allergic reaction).
On the part of the urinary system: very rarely - a single case of deterioration in renal function in a patient with chronic renal failure; in rare cases, interstitial nephritis.

Overdose

Symptoms: irritation, erythema, itching.
Treatment: should stop using Ketonal gel, rinse the skin thoroughly with running water. The patient needs to see a doctor.

Drug interaction

Since the concentration of Ketonal gel in the blood plasma is extremely low, the manifestation of symptoms of interaction with other drugs (similar symptoms with systemic use) are possible only with frequent and long-term use.
The simultaneous use of other forms for external and local use (ointments, gels) containing ketoprofen or other NSAIDs is not recommended.
Simultaneous administration of acetylsalicylic acid reduces ketoprofen binding to plasma proteins.
Ketoprofen reduces the excretion of methotrexate and increases its toxicity.
Interaction with other drugs and the impact on their elimination are not significant.
Patients taking coumarin-containing anticoagulants are advised to carry out treatment under the supervision of a physician.

special instructions

Avoid getting the gel in the eyes, on the skin around the eyes, mucous membranes.
If any side effects occur, you should stop using Ketonal gel and consult a doctor.
If the patient has forgotten to apply the gel, it should be used at the time when the next dose should be applied, but not double it.
Ketonal gel for topical use can be used in combination with other dosage forms of the Ketonal preparation (capsules, tablets, suppositories). The total daily dose, regardless of the dosage form, should not exceed 200 mg.
If skin reactions occur, incl. developed in combination with octocrylene-containing drugs, should immediately discontinue treatment.
To reduce the risk of photosensitivity, it is recommended to protect the skin-treated areas of the skin with clothing from the effects of UV rays throughout the entire treatment period and for 2 more weeks after discontinuation of the gel.
Do not use as occlusive dressings.
Hands should be washed thoroughly after each application.

Influence on ability to drive motor transport and control mechanisms

There is no data on the negative effect of the drug Ketonal gel on the ability to drive vehicles and to other potentially dangerous activities requiring concentration of attention and speed of psychomotor reactions.

Pregnancy and lactation

The drug is contraindicated for use in the third trimester of pregnancy.
Application in the I and II trimesters is possible in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.
The use of the drug Ketonal during lactation (breastfeeding) is not recommended.

Use in childhood

Contraindications: children up to 12 years.

In case of impaired renal function

Precautions should be prescribed Ketonal gel in violation of kidney function.

With abnormal liver function

Precautions should be prescribed the drug in violation of the liver.

Pharmacy sales terms

You can buy Ketonal gel without a prescription.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not higher than 25 ° C. Shelf life - 3 years.