Ketonal Duo caps 150mg #30

Ketonal Duo instruction

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Form of issue and composition

The medicament is produced in the form of capsules having a modified release. The dosage form has a transparent body and a blue cap. Each capsule contains pellets having a yellow and white color.
1 capsule contains 150 mg of active ingredient in the form of ketoprofen.

pharmachologic effect

This drug refers to non-steroidal anti-inflammatory drugs that have antipyretic and analgesic effects, and also suppress the inflammatory process.
The mechanism of action of ketoprofen is that it inhibits the synthesis of bradykinin and prostaglandin, and also strengthens the protective cell membrane - lysosomes.
The main component of the drug does not negatively affect the cartilage of the joint.
Capsules of medicament Ketonal Duo are a new variant of the dosage form, which differs from others in that it releases the active substance in a special way. Each capsule has white pellets (they make up 60% of the total content) and yellow, which are covered with a shell. White pellets quickly release their contents, and from the yellow the release process is gradual. Thanks to this, the drug combines a quick and prolonged effect.
The medication is quickly absorbed after the first application.
Eating does not affect the overall absorption of the drug, but it reduces the absorption rate. The highest concentration of the drug is observed in the blood 2 hours after its administration.
30% of the drug is transported to the synovial fluid. This amount of drug is stably stored in the synovial fluid for 30 hours. Thanks to this for a long period of time, the feeling of stiffness and pain in the joints is significantly reduced.
Metabolism of the main component of the drug occurs due to hepatic enzymes. 80% of the drug is excreted from the body with the help of the kidneys, 10% with the help of the intestine.
In patients with hepatic insufficiency, the amount of active component in the blood is observed in 2 times higher. In such a situation, it is necessary to adjust the dose and prescribe the drug to the patient in the least therapeutic dosage.
In elderly patients with reduced renal function, the processes of isolation and metabolism of the active ingredient are reduced.

Indications for use

Medication is prescribed as a remedy to help remove pain and inflammation caused by various causes.
The drug is prescribed to suppress the pain syndrome in the following situations:
    Elimination of pain in oncology practice;
    Pain after surgery;
    Neuralgia, bursitis, radiculitis, myalgia, tendonitis;
    Algodismenorea;
    Pain after injury;
    Headache.
Also, the drug is prescribed for degenerative and inflammatory diseases of the musculoskeletal system:
    Osteoarthritis;
    Arthritis seronegative (including ankylosing spondylitis, reactive arthritis or psoriatic arthritis);
    Pseudogout, gout;
    Rheumatoid arthritis.

Dosing regimen

The medication is for internal use only. It is recommended to prescribe to children from 15 years and adults 150 mg per day. The medicine is better to use in the process of eating or after that. The liquid to which the capsule should be washed should be at least 100 ml in volume.
For a day, a maximum of 200 mg of ketoprofen can be used.

Overdose

When applying the drug at a dosage exceeding the therapeutic rate, the following undesirable symptoms may appear: convulsions, a negative change in consciousness, vomiting with an admixture of blood, changes in kidney function, worsening of breathing, melena, abdominal pain, nausea, kidney failure.
In case of an overdose, treatment is performed aimed at suppressing undesirable symptoms, washing the stomach and giving activated charcoal. In order to reduce the negative effect of ketoprofen on the digestive tract, specialists can prescribe histamine receptor blockers, prostaglandins and proton pump inhibitors.

Drug Interactions

The active component of the drug is able to inhibit the effect of antihypertensive drugs and diuretics, as well as increase the effectiveness of anticonvulsant and hypoglycemic preparations of oral use.
When combined with other NSAIDs, glucocorticosteroids, salicylates and ethyl alcohol, the likelihood of negative changes in the digestive tract increases.
Parallel administration of antiaggregants, thrombolytics, anticoagulants increases the likelihood of bleeding.
Joint use of ketoprofen with ACE inhibitors and diuretics can provoke negative changes in kidney function.
Medication Ketonal Duo increases the number of such drugs in the blood, such as methotrexate, cyclosporine, preparations with lithium content, calcium channel blockers, cardiac glycosides.
Ketoprofen inhibits the action of such a drug as mifepristone. If it is necessary to prescribe Ketonal Duo, it should be taken 8-12 days after discontinuation of mifepristone.

Lactation and pregnancy

Patients who are on the 3rd trimester of pregnancy can not be prescribed this drug. Patients who are on the 1st and 2nd trimester of pregnancy should be prescribed medication only if the expected benefit significantly exceeds the possible risk.
If you need to use Ketonal Duo during lactation, you must stop breastfeeding.

Side effects

During the use of the medicine, the following undesirable reactions may appear:
    Allergic manifestations: angioedema edema, dyspnea, skin manifestations in the form of urticaria and pruritus, anaphylactoid manifestations, bronchial spasm, rhinitis;
    The system of hematopoiesis: agranulocytosis, anemia, purpura, thrombocytopenia, a decrease in the ability of platelets to aggregate;
    Organs of the senses: visual impairment, tinnitus, conjunctivitis, changes in taste preferences;
    Digestive system: bleeding in the digestive tract, exacerbation of Crohn's disease, negative changes in liver function, dry mouth, abdominal pain, vomiting, constipation, nausea, increased number of hepatic enzymes, melena, ulcers on the mucous membranes of the digestive tract, stomatitis, increased or worsened appetite, flatulence, diarrhea;
    Urinary system: nephrotic syndrome, negative changes in kidney function, hematuria, interstitial nephritis;
    Cardiovascular system: hypertension arterial, tachycardia, peripheral edema;
    CNS: disorientation, peripheral polyneuropathy, bad dreams, fatigue, dizziness, speech disorders, hallucinations, migraine, nervousness, headache;
    Other: menometrorrhagia, hemoptysis.

Contraindications

Medication can not be administered in the following cases:
    High sensitivity to any component of the drug, as well as the presence of a reaction to other NSAIDs or salicylates;
    Pregnancy (3rd trimester);
    Dyspepsia in the chronic stage;
    After surgery (aortocoronary bypass surgery);
    Kidney disease in progressive form;
    Hepatic insufficiency in severe degree;
    Crohn's disease in the period of exacerbation, exacerbation of bowel diseases, accompanied by an inflammatory process;
    Hives, rhinitis, bronchial asthma, which is caused by the use of other NSAIDs or acetylsalicylic acid;
    Lactation;
    Children under 15;
    Suspicion or presence of various types of bleeding (including cerebrovascular or in the gastrointestinal tract);
    Heart failure in decompensated form;
    Renal failure in severe degree;
    Negative changes in blood clotting and hemophilia;
    Exacerbation of peptic ulcer disease of the duodenum and stomach.
The medication should be administered with caution, if the patient has a history of such diseases as peptic ulcer, bronchial asthma, as well as cerebrovascular and cardiovascular diseases in a pronounced degree. It is recommended to be cautious in applying in the presence of peripheral arterial disease, with the long administration of NSAIDs, the parallel use of glucocorticosteroids (prednisolone), antiaggregants (acetylsalicylic acid), anticoagulants (warfarin).
Patients suffering from dyslipidemia, progressive liver disease, hyperbilirubinemia, alcoholism, renal insufficiency, chronic heart failure, arterial hypertension, blood diseases, dehydration, diabetes mellitus, ulcer complication of the digestive tract, and also with smoking should take this medicine with caution.

special instructions

With a long admission NSAIDs should monitor the blood and functional work of the liver and kidneys, more often this applies to elderly patients aged 65 years.
Patients taking ketoprofen during the therapy of hypertension, cardiovascular diseases leading to a delayed elimination of fluid from the body, it is recommended to take the medicine carefully and to monitor blood pressure more often.
Like any other non-steroidal anti-inflammatory drug, ketoprofen is able to hide the symptoms of diseases caused by the infection.
If the Ketonal Duo medication is taken at the recommended dosage, this will not affect the ability of the patient to drive vehicles and work with complex mechanisms. In the case when a patient observes unusual manifestations during the treatment with Ketonal Duo, one must be cautious, engaged in complex types of activity that require increased attention and quick response.

Terms and conditions of storage

The medicament is stored at a temperature of 15-25 ° C in a dry and dark place, distant from small children. The medicine is allowed to be used within 2 years from the moment of its release.