Flexen gel 2.5% 30gr

User manual for Flexen gel

You can buy Flexen here

Composition

    ketoprofen;
    soybean oil hydrated;
    vegetable oil;
    beeswax;
    vegetable vegetable oil;
    soy lecithin;
    gelatin;
    titanium dioxide;
    sorbitol;
    glycerol;
    sodium propyl parahydroxybenzoate;
    sodium ethyl parahydroxybenzoate.

Form of issue

Capsules. Oblong opaque gelatinous soft capsules. The color is pale yellow. Capsules contain a creamy creamy suspension of oily structure. Issue: 6 pcs. in the plate. Packing - 2 plates in a cardboard bundle.
Suppository rectal (suppositories). Oily suppositories, shaped like torpedoes. Color white or white - flint Ketoprofen content - 100 mg. Issue:: 6 pieces in a strip. Packing - 2 strips in a cardboard bundle.
Gel. Transparent homogeneous gel. Colorless. Ketoprofen content is 25 mg. Issue: Tubes - 30 and 50 gr. In a cardboard bundle - one tube.
Ampoules. Set: 1 Flexen ampoule contains lyophilized powder (homogeneous white mass) + 1 ampoule solvent (water for injection and benzyl alcohol) Issue: 6 sets in a cardboard pack.

pharmachologic effect

Has anti-inflammatory, analgesic, anti-aggregation and antipyretic effect.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The main constituent of the drug is ketoprofen, which refers to non-steroidal anti-inflammatory substances (NSAIDs). The inhibitory effect of Flexen activates the enzymes of cyclooxygenase-1. This process prevents the formation of inflammatory mediators and depresses the appearance of leukotrienes.
During the use of the drug, a persistent decrease in the activity of neutrophilic granulocytes and the stabilization of the state of the lysosome membranes are observed. Flexen deeply penetrates into the synovial and the connective membranes.

Pharmacokinetics of Flexen

With intramuscular injection, the time of development of the highest concentration in plasma is 15-30 minutes. Binding to blood proteins is 99%, bioavailability is 90% or more. After the beginning of the regular reception Flexen, the average concentration in the plasma comes in 24 hours. Therapeutic concentration is maintained in the synovial fluid for 6-8 hours.
Metabolism is observed in the liver region by convergence with glucuronic acid. The half-life process lasts for 1.5-2 hours.

Indications for use

Flexen is intended for symptomatic treatment of the following inflammatory processes:
    thrombophlebitis;
    phlebitis;
    problems of the lumbosacral plexus;
    joint pain;
    lymphangitis;
    rheumatoid arthritis;
    acute pain syndrome;
    tenosynovitis;
    lymphangitis;
    stretching;
    gout;
    damage to ligaments;
    sciatica;
    dislocation;
    synovitis;
    dorsalgia;
    radiculitis;
    renal colic;
    bone pain;
    postoperative pain;

Contraindications

The drug can not be used in the following cases:
    exacerbation of gastrointestinal diseases;
    bleeding in the gastrointestinal tract;
    acute violations of the liver;
    acute renal dysfunction;
    disorders in the hematopoiesis system, including leukopenia, hemophilia, thrombocytopenia;
    severe heart failure;
    localization of pain syndrome before or after surgery on the cardiovascular system;
    pregnancy and lactation;
    hypersensitivity to NSAIDs.
Flexen should be used with extreme caution in patients with impaired function of the digestive tract, kidneys, liver, bronchial asthma, urticaria, rhinitis, blood diseases, cirrhosis, diabetes, sepsis, cerebrovascular diseases.

Side effects

Central and peripheral nervous system: migraine, headache, insomnia, dizziness, depression, nervousness, asthenia, drowsiness, peripheral neuropathy.
Digestive system: stomach pain, vomiting, nausea, flatulence, diarrhea, gingival and hemorrhoidal bleeding, increased level of hepatic transaminases in blood serum, perforation of the gastrointestinal mucosa.
Respiratory system: dyspnea, bronchospasm, laryngeal edema, nosebleed, hemoptysis, rhinitis, dyspnosis.
Cardiovascular system: increased blood pressure, tachycardia.
Urinary system: renal dysfunction, urethritis, cystitis, edema, nephrotic syndrome, hematuria.
Sense organs: violation of accommodation and clarity of vision, tinnitus, conjunctivitis, hearing loss.
The system of hematopoiesis: leukopenia, anemia, thrombocytopenia, agranulocytosis.
Allergic reactions: skin itching, skin rash, exudative erythema, Stevens-Johnson syndrome, angioedema, photodermatitis, anaphylactic shock.
Other manifestations: eczema, muscle tic, increased sweating, thirst, myalgia, vaginal bleeding.

Instructions for use Flexen (Method and dosage)

Capsules of the preparation Flexen swallow whole, without chewing, washing with water (50 - 100gr). The medicine is taken after a meal. Dosage varies from 2 to 6 capsules per day, depending on the doctor's prescription.
Instructions for the use of flaxen candles
This form of the drug is applied rectally. The daily dose is 1 - 2 suppositories.

Gel Instruction

The ointment is applied topically, in small amounts and a thin layer. The substance is lightly rubbed over the focus of inflammation. The procedure of rubbing is carried out 2 - 3 times a day. The course of treatment should not last more than 2 weeks. Further use should be agreed with the attending physician.
Flexen injections are carried deep into the muscle tissue. A dose of 100 mg 1 or 2 times a day. After the elimination of acute pain syndrome, you can go to the use of capsules or candles. The maximum dose of injections per day is 300 mg.

Overdose

Overdose of the drug is expressed in the following manifestations: bleeding, drowsiness, nausea, disruption of the kidneys and liver, epigastric pain.
Therapeutic therapy is carried out by washing the stomach and using adsorbents. Follow-up therapy depends on the individual condition of the patient.

Interaction

Results of Flexen interaction with the following drugs:
    Antithrombotic drugs - increasing the effectiveness of antithrombotic drugs.
    Waminamine K antagonists increase the effectiveness of these antagonists.
    Substances containing ethanol - increases the effect of alcohol, leads to a risk of bleeding in the gastrointestinal tract.
    Preparations containing lithium - enhancing the effect of lithium-containing substances.
    Enhance the effect of heparin.
    Increases the toxicity of methotrexate.
    Strengthening the effect of the bicorticoids.
    Reduction of the action of peripheral vasodilators.
    Decreased action of spironolactone.
    Incompatibility with tramadol.
    Increasing the effectiveness of ticlopidine.
    Increased side effects of estrogens with estrogen preparations.
    Increased risk of bleeding with cefamandole.
    Risks of ulceration of the gastrointestinal tract when interacting with NSAIDs.
    Destabilization of platelet aggregation with valproic acid.
    Antacids reduce the effectiveness of Flexen absorption.
    Kolestyramin lowers the absorption efficiency of Flexen.
    Myelotoxic substances increase hematotoxicity.

Terms of sale

To buy online Flexen you don't need a prescription.

Storage conditions

The drug is recommended to store at a temperature of up to + 25 degrees C. This temperature regime applies to all forms of release.
Shelf life of all forms of release is 3 years.

special instructions

During treatment, it is necessary to monitor the functional state of the kidneys and liver, as well as monitor the condition of peripheral blood.
It is forbidden to drink alcohol.
In case of visual impairment, consultation with an ophthalmologist is necessary.
During the reception Flexen, should be careful when interacting with complex mechanisms, when driving transport, as well as in jobs where a fast psychomotor reaction is needed.

Children

Children and adolescents under the age of 18 are not recommended to use Flexen.

Reviews of Flexen

Reviews about injections Flexen are positive. Many patients suffering from radiculitis and using this drug, indicate that the pain passes after 10 - 15 minutes after the injection.
Gle Flexen is simply indispensable for back pain, so many people use the gel to apply it in practice.
Reviews of candles in gynecology
Flexen is prescribed for ovarian cysts. According to many women, the medicine works very effectively. After treatment with Flexen for 10 days and subsequent reception of additional funds, the cyst disappears. Candles Flexen in gynecology are very popular and popular.