Meloxicam solution 10mg/ml 1.5ml #3

Meloxicam solution instruction for use

You can buy Meloxicam solution here

Solution for parenteral administration Meloxicam is a non-steroidal anti-inflammatory drug with anesthetic and antirheumatic effect. It is used in various pathologies of the musculoskeletal system, accompanied by inflammation and pain.

Release form and composition

The drug Meloxicam solution is available in several dosage forms. The solution for parenteral (intramuscular) administration is yellow with a greenish tint, it is transparent and should not contain impurities or suspensions. The main active ingredient of the drug is meloxicam, its content in 1 ml of solution is 10 mg. Also included in the preparation are auxiliary components, which include:
    Glycine.
    Meglumine.
    Poloxamer 188.
    Sodium hydroxide.
    Sodium chloride.
    Glycofurol.
    Water for injections.
Solution for parenteral administration Meloxicam is contained in 1.5 ml plastic transparent ampoules (15 mg of the active substance), which are packaged in a blister pack of 3, 5, or 10 pieces. The carton pack contains one blisters and instructions for use of the drug.

pharmachologic effect

The active ingredient of the solution for parenteral administration. Meloxicam solution is a representative of the pharmacological group of nonsteroidal anti-inflammatory drugs. It inhibits the activity of the enzyme cyclooxygenase (COX), which is responsible for the chemical transformation of arachidonic acid into prostaglandins during the development of the inflammatory reaction. Prostaglandins lead to an increase in local and general temperature, the development of pain, swelling and hyperemia (increased blood supply in the inflammatory response area). Meloxicam reduces the concentration of prostaglandins, due to which it has antipyretic, anti-inflammatory and analgesic effect.
After intramuscular administration of the solution of Meloxicam, the active substance quickly accumulates in the blood plasma and is evenly distributed in the tissues of the body with a higher concentration in the structures of the musculoskeletal system. Meloxicam is metabolized in the liver to form inactive degradation products, which are mainly excreted in the urine.

Indications for use

The use of the solution for parenteral administration Meloxicam is indicated for the pathogenetic treatment of inflammatory pathology of the structures of the musculoskeletal system, which includes:
    Osteoarthritis is a degenerative-dystrophic pathology in which the properties of the cartilage tissue of the joints are disturbed with the development of prolonged inflammation.
    Rheumatoid arthritis is an autoimmune inflammation of the joints, in which the immune system produces antibodies to their tissues.
    Ankylosing spondylitis or ankylosing spondylitis is an autoimmune process that affects joints and intervertebral joints with severe pain.
    Pain and inflammatory symptoms of different nature with a predominant localization in the structures of the musculoskeletal system.
The use of the solution for parenteral administration Meloxicam does not affect the course or progression of the pathological process. It allows you to reduce the inflammatory process at the time of use.

Contraindications

Use of the solution Meloxicam is contraindicated in a number of pathological and physiological states of the body, which include:
    Individual intolerance to the active substance or auxiliary components.
    Hypersensitivity to drugs from the group of nonsteroidal anti-inflammatory drugs.
    The history of the “aspirin” triad is the development of asthma, recurrent nasal polyposis and sinuses, as well as intolerance to acetylsalicylic acid, which belongs to the nonsteroidal anti-inflammatory drugs in the pharmacological group.
    Gastrointestinal, intracranial, or other bleeding at the time of use of the drug or transferred in the recent past.
    Peptic ulcer with localization in the stomach or duodenum in the stage of clinical and laboratory exacerbation.
    Severe insufficiency of the functional activity of the liver, kidneys or cardiovascular system (in particular, acute or chronic heart failure in the decompensation stage).
    Pregnancy at any time of its course, as well as breastfeeding.
    Children age less than 15 years.
Before using the solution for parenteral administration of Meloxicam, you need to make sure that there are no contraindications.

Dosage and administration

Solution for parenteral administration Meloxicam is used only intramuscularly. Usually it is administered once a day, it is also possible twice the introduction during the day, provided that the average daily dosage does not exceed 15 mg. The drug is used within 2-3 days of the acute course of the inflammatory process, then the use of the oral form (tablets) of the drug is recommended.

Side effects of Meloxicam solution

The use of the solution for intramuscular injections of Meloxicam can lead to a number of adverse reactions from various organs and systems:
    Digestive system - nausea, vomiting, abdominal pain with predominant localization in the stomach (epigastric), constipation, transient (transient) increase in the activity of hepatic transaminase enzymes (ALT, AST) in the blood, indicating damage to liver cells, sour eructation, esophagitis (inflammation esophagus), ulceration in the stomach or duodenum, latent or apparent gastrointestinal bleeding.
    Nervous system - headache, drowsiness, tinnitus, intermittent dizziness, vertigo (severe dizziness).
    Cardiovascular system - increased systemic arterial pressure, palpitations, flushing of the face with a sensation of heat and redness, the development of peripheral edema of tissues.
    Blood and red bone marrow - anemia (anemia), a decrease in the number of leukocytes (leukopenia), platelets (thrombocytopenia), neutrophils (neutropenia) in the blood.
    Respiratory system - the appearance of cough and exacerbation of bronchial asthma with its presence in the past.
    The urinary system - a decrease in the functional activity of the kidneys, which is manifested by an increase in the level of creatine in the blood.
    Allergic reactions - a rash on the skin, itching, urticaria (rash and swelling of the skin, resembling a nettle burn).
With the development of pronounced side effects, the use of the solution for parenteral administration of Meloxicam is stopped.

special instructions for Meloxicam solution

Before using the solution for intramuscular injections, Meloxicam should carefully read the annotation to the drug. There are several special indications regarding its use that are worth paying attention to, these include:
    With the development of latent or overt gastrointestinal bleeding, the use of the drug should be discontinued.
    In the presence of a concomitant decrease in circulating blood volume after surgery, against the background of dehydration, there is a risk of a decrease in glomerular filtration with the development of renal failure.
    In the case of the presence of concomitant pathology of the kidneys, it is necessary to periodically determine the laboratory indicators of their functional activity.
    With a significant and persistent increase in hepatic transaminases, the drug should be discontinued.
    To reduce the risk of side effects (especially gastric or duodenal ulcers), treatment should begin with the minimum therapeutically effective dose of the Meloxicam solution.
    Solution for intramuscular injections Meloxicam can interact with drugs of other pharmacological groups, therefore, their possible use for the treatment of other diseases must be warned to the attending physician.
    During drug treatment, activities that require an increased concentration of attention and speed of psychomotor reactions should be avoided, which is associated with the possible development of side effects from the central nervous system.
In the pharmacy network, the solution for parenteral administration of Meloxicam is released by prescription. It is not recommended to use it yourself without an appropriate purpose.

Overdose

With a significant excess of the recommended therapeutic dose of the solution for parenteral administration Meloxicam develops drowsiness, abdominal pain, possibly gastrointestinal bleeding. In this case, symptomatic therapy is carried out in a medical hospital.

Terms and conditions of storage

The shelf life of the solution for parenteral administration of Meloxicam is 2 years from the date of manufacture. After using the solution, its residues in the ampoule should be disposed of, since they are not suitable for further use. The drug should be stored in a dark place inaccessible to children at air temperature not higher than + 25 ° C.

Terms of sell

You can buy Meloxicam solution without a prescription.