Sirdalud tabs 4mg #30

Instruction for Sirdalud

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Composition

Depending on the form of release, 1 tablet of Sirdalud contains 4 mg or 2 mg of tizanidine. Also, the composition contains auxiliary substances:
    ICC;
    lactose monohydrate;
    stearic acid;
    Silica dioxide anhydrous colloid.

Form of issue

The package contains 30 tablets of 2 and 4 mg, the blister itself contains 10 tablets, and the package contains 3 blisters.
Tablets of 2 mg: white, flat, round, on one side of the line, on the other - the code "OZ".
Tablets of 4 mg: white, flat, round, on one side the inscription "RL", on the other - crossing lines.

pharmachologic effect

It is a central muscle relaxant.

Pharmacodynamics and pharmacokinetics

Tizanidine is a relaxant of skeletal musculature, the main place of its action is the spinal cord. This drug reduces the increased muscle tone of the skeleton, relieves spasm, increases the force of arbitrary contractions. Sirdalud is effective in chronic spasticity of cerebral and spinal genesis and with acute spasm of muscles. In addition, it has a light analgesic effect.
Tizanidine is absorbed fairly quickly and virtually completely. The largest indicator of the concentration level of the drug in plasma can be observed about an hour after its adoption. The substance is excreted by the kidneys.

Indications for the use of Sirdalud

From what tablets Sirdalud? Indications for use are as follows:
    muscle spasm, which is associated with diseases of the spine (these include lumbar and cervical syndromes), or which appeared after the surgeon's intervention;
    spasticity of skeletal muscles in the manifestation of neurological diseases (multiple sclerosis, chronic myelopathy, cerebral palsy, degenerative diseases of the spinal cord).

Contraindications

This medication has a number of known contraindications:
    individual intolerance of the component present in the preparation;
    significant violations of the liver;
    children and teenagers under 18 years of age.
With special care, it is necessary to take the drug to patients older than 65 years, as well as patients with impaired renal function.

Side effects

Side effects of Sirdalud include:
    dizziness, drowsiness, sleep disturbance, insomnia;
    bradycardia, lowering blood pressure;
    upset stomach, nausea, dry mouth;
    increased fatigue, muscle weakness;
    increased activity of hepatic transaminases.
As a result of a sharp cessation of taking Sirdalud after a long period of treatment, tachycardia, an increase in pressure may develop, which can lead to a disruption in the blood circulation of the brain, so the dose should be reduced gradually, until it is completely eliminated.
As a result of clinical studies, the following undesirable phenomena were detected, the frequency of which was not revealed:
    confusion, hallucinations, vertigo;
    blurred vision;
    hepatic insufficiency, hepatitis;
    withdrawal syndrome, asthenia.

Instructions for the use of Sirdalud (Method and dosage)

The medicine is taken orally, the dose is determined based on the individual characteristics of the human body. To minimize the risk of side effects, you should start with a dose of 1 tablet (2 mg) or half a tablet (4 mg) 3 times a day.
In severe muscle spasm, tablets of 2 mg or 4 mg are prescribed 3 times a day. In especially severe cases, you can take an additional 2 mg or 4 mg dose before bed.
When spasticity of skeletal muscles is manifested, which can be caused by neurological diseases, the initial dose is 6 mg per day, taken in 3 divided doses. Increase the dose should be gradual, 2-4 mg, an interval of 3 to 7 days. The optimal effect is achieved when taking 12-24 mg per day 3-4 times a day. Do not take a dose above 36 mg per day.
People over 65 years of age are advised to start taking the drug with a minimal dose, incrementally increasing it to the optimal size, which will achieve effective therapy and minimal side effects.
Patients with impaired renal function should begin treatment with a dose of 2 mg per day at a time. Dose is increased gradually, in small steps, taking into account the effectiveness and tolerability of the drug.

Instructions for use of Sirdalud MR

The preparation is a capsule containing 6 mg of tizanidine. The initial dose of Sirdalud is 1 capsule per day. Gradually, the dose can be increased by 6 mg at intervals of 3 to 7 days. For the majority of patients, the optimal dose is 12 mg per day. In rare cases, the dose can be increased to 24 mg (4 capsules) per day.
The injections of this drug can be prescribed exclusively by a doctor.

Overdose

Overdosage with the drug Sirdalud Tinazidine may be expressed as follows:
    lowering blood pressure;
    vomiting, nausea;
    drowsiness, dizziness, anxiety, miosis;
    coma, respiratory failure.
Treatment: repeated intake of activated carbon and forced diuresis will speed up the removal of the drug from the body. After excretion, symptomatic treatment is performed.

Interaction

Simultaneous consumption of the drug with inhibitors of cytochrome CYP1A2 leads to an increase in the level of tizanidine in the plasma, which in turn leads to the appearance of symptoms of an overdose. Simultaneous consumption of Sirdalud with inducers CYP1A2 leads to a decrease in the level of tizanidine, which causes a decrease in the medicinal properties of the drug.
Contraindicated in the use of Sirdalud along with fluvoxamine, ciprofloxacin. The result of simultaneous application can be a significant reduction in blood pressure, which is accompanied by dizziness and drowsiness, in some cases - loss of consciousness.
It is not recommended to take the drug with antiarrhythmic drugs (such as Propafenone, mexiletine, amiodarone), certain fluoroquinolones (norfloxacin, enoxacin, perfloxacin), cimetidine, ticlopidine, oral contraceptives, rofecoxib.
With caution, it is necessary to take Sirdalud with those drugs that extend the QT interval (amitriptyline, cisapride, azithromycin, etc.).
The use of Sirdalud together with rifampicin reduces the content of tizanidine in plasma and, accordingly, reduces the therapeutic effect of the drug.
Treatment with the drug of smoking men may require an increase in the dose. Alcohol should be avoided, since the drug can increase the negative effect of alcohol on the central nervous system. The sedative effect of Sirdalud can enhance sleeping pills, sedatives and antihistamines.

Terms of sale

To buy Sirdalud you don't need a prescription.

Storage conditions

Store at a temperature not exceeding 25 ° C, in a place inaccessible to children.
Shelf life is 3 years.

special instructions

The drug is not recommended for patients who are intolerant to galactose, as well as suffering from severe lactase deficiency or glucose / galactose malabsorption, due to the presence of lactose in the composition.
Since one of the side effects of the drug is drowsiness, it is highly recommended to refrain from driving a car or performing work related to machinery or machines.

Reviews of Sirdalud

Comments on Sirdalud tablets are left by patients of different ages. The average score on the forums for this medication is 3.9 points out of 5. Many patients report the occurrence of side effects such as drowsiness and fatigue. There are also reports of the effect of the drug on the liver.
Reviews of doctors about Sirdalud: the drug is used for symptomatic treatment, it helps to reduce spasms of the muscles of the skeleton. If there is a strong manifestation of side effects or a lack of results for 3 days of taking the medication, you should contact your doctor to adjust the therapy.