Angeliq tabs #28

Instruction for Angeliq

You can buy Angeliq on this page

Composition

Estradiol hemihydrate, drospirenone, corn starch, lactose monohydrate, pregelatinized corn starch, magnesium stearate, macrogol, povidone, talc, iron dye red oxide, titanium dioxide hypromellose.

Form of issue

Round tablets biconvex, gray-pink in film coating in blister in cardboard pack No. 28 and 84.

pharmachologic effect

Antigonadotropic, gestagenic, antiandrogenic, antimineralocorticoid.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug Angelique refers to hormonal drugs, which includes estrogen - estradiol and drospirenone, which is a derivative of spironolactone. It is intended for hormone replacement therapy (HRT) in postmenopausal women in the presence of menopausal disorders (increased sweating, hot flashes, decreased mood, sleep disturbances, irritability, cardialgia, decreased libido, involuntary changes in the genito-urinary tract) and avoids regular withdrawal bleeding in phase or cyclic HRT.
Estradiol - provides effective replacement of the estrogen deficiency in the body of a woman after the onset of menopause and relief of vegetative and psychoemotional symptoms of menopause. Estradiol effectively prevents the process of bone loss due to estrogen deficiency and manifests itself by suppressing the function of osteoclasts and enhancing the process of bone destruction. Long-term use of HRT after the onset of menopause reduces the risk of fractures of peripheral bones. HRT has a beneficial effect on the collagen content in the skin, its density and slows the formation of wrinkles.
Drospirenone-antimineralocorticoid effect, increases the rate of excretion of sodium and water from the body, which prevents weight gain, increased blood pressure, the appearance of swelling, and other symptoms associated with fluid retention. Drospirenone does not possess any estrogenic, androgenic, glucocorticosteroid activity. Combination with anti-androgenic and antimineralocorticoid action, provides drospirenone pharmacological profile similar to natural progesterone.
Reception Angelica reduces the total level of cholesterol and LDL (low-density lipoproteins) and the concentration of triglycerides. Angelica, due to the anti-androgenic properties of drospirenone, affects androgen-dependent diseases (androgenic alopecia, acne, seborrhea).

Pharmacokinetics

Estradiol - completely and quickly absorbed in the digestive tract. Food intake for its bioavailability is not affected. During the first passage of estradiol through the liver, it is actively metabolized to catechol estrogens, estrone, glucuronide conjugates, which do not have or have weakly expressed estrogenic activity. Metabolites are excreted through the intestine and kidneys with a half-life of 24 hours.
Drospirenone - completely absorbed in the digestive tract. Bioavailability of the order of 76-85%. Food intake for its bioavailability is not affected. Most of it is excreted through the intestines and kidneys in the form of metabolites.
The levels of estradiol and estrone after the end of the course of taking Angeliq to the initial values ​​are returned within five days.

Indications for use

In postmenopause with climacteric disorders as hormone replacement therapy (HRT) and a prophylactic against the development of postmenopausal osteoporosis.

Contraindications

High sensitivity, thromboembolism, hepatic / renal failure, oncology, vaginal bleeding, lactose intolerance, lactase deficiency.
Angelica should be taken with caution to patients with bronchial asthma, epilepsy, hemangioma of the liver, porphyria, migraine, retinal vascular thrombosis, mental disorders, endometriosis, obesity, diabetes mellitus, obstructive bile ducts.

Side effects of Angeliq

Breast enlargement / soreness, thromboembolism, insomnia, anxiety, fatigue, varicose veins, increased blood pressure, swelling, mood laxity, dry mouth, dizziness, migraine headaches, nausea, abdominal pain, flatulence, indigestion, vomiting, change in taste, spotting, changes in libido, increased sweating, breakthrough uterine bleeding, weight change, asthenia, muscle spasms, arthralgia, allergic reactions.
Angelique, instructions for use (Method and dosage)
Tablets Angeliq ingest one tablet a day whole, squeezed with liquid. The drug should be taken at the same time of day. If you missed taking a pill you need to take it as soon as possible. If more than 24 hours have elapsed after the usual time, you do not need to take an extra pill. In cases of missing several pills, there is a risk of developing vaginal bleeding. In case of switching to Angelique from another combination, treatment can be started at any time. In the case of switching from taking a combined preparation for a cyclic HRT regimen, Angelic reception should be started after the end of the current therapy cycle.

Overdose

When taking the drug in high dosage, there is a risk of developing vaginal bleeding, nausea, vomiting.

Interaction

It is necessary to inform the doctor about the drugs that the patient is currently taking.
The drugs that reduce the effectiveness of Angeliq include barbiturates, phenytoin, primidone, rifampicin, carbamazepine, griseofulvin, oxcarbazepine, felbamate, topiramate and LS containing St. John's Wort.
With the joint intake of Angeliq with drugs for the treatment of viral hepatitis C and HIV, clinically significant increases / decreases in the concentration of progestin and estrogen can be observed.
Antifungal drugs (fluconazole, itraconazole, voriconazole), verapamil, macrolides (erythromycin, clarithromycin), grapefruit juice can increase the plasma concentration of estrogen, progestin or both substances.
Abuse of alcoholic beverages when taking Angeliq can promote the growth of concentration, circulating estradiol.
Receiving Angelica patients who are on antihypertensive therapy can increase the hypotensive effect.

Reviews

Reviews about the drug Angelique among the main number of patients are positive.
    "... I take the drug a long time. As a result, got rid of hot flashes, terrible headaches, overall well-being improved. I took the drug under supervision and regularly took tests and underwent examinations. Also, you need to take breaks in taking this medication. I recommend".
    "... With the onset of menopause, the state of health worsened. Depression, a hot flush, dryness of the vaginal mucosa. Have registered Angeliq. After 3 months of reception, energy and activity appeared. Passed negative symptoms. Side effects did not feel. There was never a headache, nausea, dizziness, stools. I'm happy with the result. "