Livial tabs 2.5mg #28

User manual for Livial

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Composition

The active ingredient is Tibolon -2.5 mg.
Excipients:
    100 mg - lactose;
    10 mg - potato starch;
    0.2 mg - ascorbyl palmitate;
    0.5 mg - magnesium stearate;
    purified water (it is removed during production).

Form of issue

Produced in the form of tablets with active substance Tibolon - 2.5 mg.
Tablets are flat, round white or close to it color. The edges of the tablet are bevelled, on opposite sides are squeezed out - "MK" over "2" + "ORGANON" and a five-pointed star.
One package contains 28 tablets (1 blister) or 84 tablets (3 blisters).

pharmachologic effect

Estrogen is progestational, antimuscular.

Pharmacodynamics and pharmacokinetics

Medicinal product Livial shows estrogenic, gestagenic, and also weak androgenic activity. Helps stabilize the hypothalamic-pituitary system during the menopause, induces a decrease in the production of gonadotropic hormones.
In the period of postmenopause, delays the destruction of bone tissue, weakens such symptoms of climacteric syndrome, as headaches, increased sweating, "flushes" of blood to the face.
Positively affects the general mood and libido, due to an increase in the concentration of peripheral and central opioids. Does not have a stimulating effect on the proliferation of the endometrium, at the same time, stimulating the mucous membrane of the vagina. Suppress the process of ovulation in fertile women.
It prevents the development of the disease - osteoporosis, lowers the content of calcium and phosphates in the blood serum.
Tibolon is highly absorbent. The process of absorption after oral administration proceeds quickly and completely.
Transformation occurs in the liver with the release of active and inactive metabolic products.
The concentration of Tibolone in the blood plasma is low and reaches its peak after 60-90 minutes after internal administration.
T1 / 2 metabolites of the drug is about 7 hours, without subsequent accumulation in the body.
It is excreted, mainly in the form of metabolites, with the help of kidneys. A small part is excreted with feces and bile.

Indications for use

    symptomatic therapy of estrogenic insufficiency in postmenopausal women;
    prevention of osteoporosis in postmenopause in women who are prone to frequent fractures and with individual intolerance to other groups of drugs used to prevent disease.

Contraindications

    the period of breastfeeding;
    period of pregnancy;
    vaginal bleeding of unclear etiology;
    period of time less than 12 months after the last menstruation;
    diagnosed or suspected malignant tumor of the breast (including in anamnesis);
    endometrial hyperplasia not treated;
    diagnosed or suspected estrogen-dependent malignant entities, in particular endometrial cancer and others (including history);
    thromboembolism and thrombosis (arterial or venous) present or in the past (including thrombophlebitis and deep vein thrombosis, myocardial infarction, pulmonary embolism, hemorrhagic or ischemic cerebrovascular pathologies);
    prethrombotic conditions (including angina pectoris and transient ischemic attacks) that are currently or have been observed in the past;
    confirmed thrombophilic pathologies (including deficiency of antithrombin, C or S proteins);
    cardiovascular insufficiency, which is in the stage of decompensation;
    Numerous or expressed reasons for the possible development of arterial or venous thrombosis (including uncontrolled arterial hypertension, atrial fibrillation, damage to the heart valves with complications, infective endocarditis, serious operations with prolonged immobilization, obesity, extensive trauma);
    liver failure;
    acute liver pathology or previous liver disease leading to changes in its function;
    detected or previously diagnosed benign or malignant neoplasms of the liver (including liver adenoma);
    otosclerosis, developed on the background of taking hormonal contraceptives or during the previous period of pregnancy;
    porphyria;
    rare hereditary pathologies (including lactase deficiency, galactose intolerance, glucose-galactose malabsorption);
    hypersensitivity to the components of Livial.

With caution should appoint Livial:

    with fibroids of the uterus (leiomyoma) and / or endometriosis;
    at an increased risk of developing estrogen-dependent tumors (for example, breast cancer detected in immediate relatives);
    with cardiovascular failure without symptoms of decompensation;
    with controlled arterial hypertension;
    at an elevated level of cholesterol in the blood;
    with cholelithiasis;
    with diabetes mellitus;
    with systemic lupus erythematosus;
    with severe headaches or migraine;
    with epilepsy;
    with endometrial hyperplasia in the anamnesis;
    with renal insufficiency;
    with bronchial asthma;
    with otosclerosis, which is not associated with taking hormonal contraceptives or pregnancy.
The presence of any of these pathologies, observed earlier or currently, is a risk factor for their exacerbation or relapse, during the application of Livial. In the presence of such conditions the patient must be under the constant supervision of the attending physician.

Side effects

Digestive system:

    lower abdominal pain;
    Dyspeptic disorders (flatulence, diarrhea);
    violations of the liver.

Central nervous system:

    dizziness;
    migraine;
    headache;
    depression.

Endocrine system:

    weight changes;
    pretybial edema.

Reproductive system:

    thickening of the endometrium;
    vaginal discharge;
    bleeding or spotting from the vagina;
    genital itching;
    tenderness of the mammary glands;
    candidiasis vulvovaginitis;
    dysplasia of the cervix;
    painful sensations in the pelvic region;
    vulvovaginitis.

Allergic manifestations:

    itching;
    seborrheic dermatitis;
    rash.

Others:

    impaired vision;
    fluid retention;
    pain in the muscles and joints.

Livial, instructions for use (Method and dosage)

The instruction on Livial recommends 1-well a tablet of a preparation as a daily dose. Correct the dose of the drug, taking into account the age of the patient, is not required. The tablet is taken at the same time of the day, swallowing it whole and washing it with water.
The drug Livial is produced in blisters, on the underside of which is marked with the days of the week. The day of taking the tablets should coincide with the day marked on the blister.
For example, when taking the first pill on Monday, you should take a pill from the top of the blister line labeled "Monday" (Mon). Further taking the drug is carried out sequentially (along the rows of tablets) in accordance with the marking and the day of administration, including subsequent blisters.
During therapy, try not to skip the next dose of the drug and do not take breaks in treatment, unless it is previously recommended by a doctor.
If you accidentally miss the daily time of taking Livial, the next pill should be taken as early as possible for 12 hours.
After 12 hours, you should skip this procedure and take the next tablet in the blister at the usual time. Do not take twice the dose to compensate for missed intake.

Overdose

There may be vaginal bleeding, nausea, a feeling of malaise.
Most often, the symptoms of overdose are mild and do not require specific treatment.

Interaction

The drug Livial can enhance the action of anticoagulants, in this regard, the dose of the latter is subject to adjustment.
Barbiturates, hydantoins, carbamazepine, rifampicin, can enhance the metabolism of Tibolone.
Medicines containing Hypericum perforatum (Hypericum perforatum) increase the metabolism of progestins and estrogens.

Storage conditions

Keep Livial in a place protected from light and inaccessible to children.
At temperatures between 2 ° C and 25 ° C.
Shelf life - 2 years.

special instructions

The drug is not used as a contraceptive.
Livial is recommended to appoint no earlier than 12 months after the last menstruation (natural menopause). In the case of surgical menopause, the drug is prescribed immediately after surgery.
Exceeding the daily dose of Livial (1 tablet) is not recommended, because of the risk of bleeding from the vagina.
During the therapy, medical monitoring of the condition of patients suffering from epilepsy, migraine, diabetes, hypercholesterolemia, impaired renal function (including in history) is necessary.

Analogues of Livial

Among the often prescribed drugs of hormone replacement therapy with menopause there are analogues of Livial:
    Angeliq;
    Femoston;
    Klimonorm, etc.
When searching for an effective medication during the postmenopausal period, they often discuss the topic: - what is better for Angelique or Livial; Femoston or Ledibon, etc.
It is worth noting that hormone replacement therapy for menopause can be prescribed only by an experienced gynecologist, after a detailed examination
and anamnesis.
Therefore, to give an unambiguous answer, which of the existing drugs is better: Livial, Angelica, Proginova and others, it is impossible. Hormone therapy is selected individually for each patient, and carried out under the constant supervision of a physician, in compliance with all of its recommendations.

During pregnancy (and lactation)

Medicinal product Livial is contraindicated for use during pregnancy and during breastfeeding.

Reviews about Livial

The doctors' comments about Livial, with an individual approach to each patient, speak of him as an effective and relatively safe drug in the treatment of menopause.
Reviews of women about Livia are more often positive, although with references to various negative side effects. Recall that you can not choose hormonal drugs yourself. Adequate treatment can be prescribed only by a gynecologist.