Clotrimazole vaginal tabs 100mg #6
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Clotrimazole vaginal tabs instruction for useYou can buy Clotrimazole vaginal tabs hereComposition1 vaginal tablet contains:active ingredient: clotrimazole 100 mgexcipients: lactose, potato starch, adipic acid, sodium bicarbonate,..
Clotrimazole vaginal tabs instruction for use
You can buy Clotrimazole vaginal tabs here
1 vaginal tablet contains:
active ingredient: clotrimazole 100 mg
excipients: lactose, potato starch, adipic acid, sodium bicarbonate, magnesium stearate, colloidal silicon dioxide, sodium lauryl sulfate.
White, biconvex tablets with a smooth surface, oblong in shape, rounded at one end and flat with the other,
ATX Code: [G01AF02]
Clotrimazole tablets are a broad-spectrum antifungal agent for topical use. The antimycotic effect of the active substance (imidazole derivative) is associated with impaired synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes the subsequent lysis of the cell. In small concentrations, it acts fungistatically, and in large concentrations - it is fungicidal, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells. Effective against dermatophytes, yeast-like and mold fungi, as well as the pathogen of multi-colored depriving Pityriasis versicolor (Malazessia furfur) and the causative agent of erythrasma. It has antimicrobial action against gram-positive (staphylococcus, streptococcus) and gram-negative bacteria (Bacteroides, Gardiierella vaginalis), as well as against Trichomonas vaginalis.
When using Clotrimazole tablets and intravaginal absorption is 3-10% of the administered dose. High concentrations in the vaginal secretion and low blood concentrations are maintained for 48-72 hours. In the liver, it is rapidly metabolized to inactive metabolites.
Indications for use
genital infections caused by yeast-like fungi of the genus Candida and / or Trichomonas vaginalis (vulvovaginal candidiasis, trichomoniasis);
genital superinfection caused by microorganisms sensitive to Clotrimazole tablets;
sanitation of the birth canal before childbirth.
Contraindications for Clotrimazole vaginal tablets
Hypersensitivity to Clotrimazole tablets or excipients in the first trimester of pregnancy. You should avoid the use of tablets during menstruation. With care - the lactation period.
Use during pregnancy and lactation
In clinical and experimental studies it was not established that the use of the drug during pregnancy or during breastfeeding has a negative impact on the health of the woman or the fetus (child). However, the question of the advisability of prescribing the drug should be decided individually after consulting a doctor.
Dosage and administration
For intravaginal use only. Vaginal tablets are administered in the evening into the vagina, as deeply as possible, in the supine position with slightly bent legs, daily for 6 days, 1 vaginal tablet of 100 mg each. A second course of treatment is possible after consulting a doctor. For the rehabilitation of the birth canal is recommended a single injection of one tablet.
Side effect of Clotrimazole tablets
Itching, burning and swelling of the vaginal mucosa, vaginal discharge, headache, gastralgia, frequent urination, intercurrent cystitis, burning sensation in the penis of a sexual partner, pain during intercourse.
The use of the drug in high doses does not cause any reactions and conditions, life-threatening.
In the case of an unintended use of the drug (inside), the following symptoms are possible: anorexia, nausea, vomiting, gastralgia, abnormal liver function; rarely - drowsiness, hallucinations, pollakiuria, skin allergic reactions.
There is no specific antidote. It is necessary to appoint inside activated carbon. If necessary, treatment is symptomatic.
Interaction with other drugs
With vaginal administration, Clotrimazole tablets reduces the activity of amphotericin B and other polyene antibiotics. With simultaneous use with nystatin, clotrimazole activity may be reduced.
To prevent urogenital reinfection, simultaneous treatment of sexual partners is necessary.
When trichomoniasis for a more successful treatment in conjunction with Clotrimazole tablets should use other drugs that have a systemic effect (for example, metronidazole inside).
With simultaneous infection of the labia and adjacent areas (candidal vulvitis), local treatment with clotrimazole cream should be additionally carried out.
During pregnancy, treatment with vaginal tablets should be carried out without an applicator.
Patients with liver failure should periodically monitor the functional state of the liver.
If there is evidence of hypersensitivity or irritation, treatment is stopped. If there is no effect for 4 weeks, the diagnosis should be confirmed.
Vaginal tablets of 100 mg. On 6 tablets in the blister from PVC / A1 foil. On 1 blister together with the application instruction in a cardboard pack.
Shelf life - 3 years.
Do not apply after the expiration date.
At temperatures below 25 °, out of the reach of children.
Pharmacy sales terms
You don't need a prescription to buy Clotrimazole tablets.