All Categories

  • All Categories
  • Allergy
  • Antibiotics
  • Antiseptics
  • Cardiovascular
  • Contraception
  • Dentes and mouth
  • Dermatology
  • Endocrinology
  • Eyes and vision
  • Food supplements
  • Genito-urinary system
  • Havinson's peptides
  • Hemorrhoids
  • Herbal tea
  • Herbs
  • Homoeopathy
  • Hormonal
  • Immune system
  • Joints and bones
  • Medical accessories
  • Medical cosmetology
  • Men's Health
  • Midwifery, gynaecology
  • Miscellaneous
  • Natural oils and tincture
  • Neurology
  • Oncology
  • Otolaryngology
  • Pain relief
  • Poisoning
  • Respiratory system
  • Stomach, bowels, livers
  • Vitamins

Clotrimazole ointment 1% 20gr

  • $6.31
  • 3 or more $6.19
  • Availability:In Stock

Clotrimazole ointment user manualTo buy Clotrimazole ointment just add it to your cartpharmachologic effectKetoconazole-Acre - antifungal agent. It has fungicidal and fungistatic effect. The mechanism of action is to inhibit the s..

Tags: ointment

Clotrimazole ointment user manual

To buy Clotrimazole ointment just add it to your cart

pharmachologic effect

Ketoconazole-Acre - antifungal agent. It has fungicidal and fungistatic effect. The mechanism of action is to inhibit the synthesis of ergosterol and changes in the lipid composition of the membrane. It is active against the pathogen of multi-colored depriving Malassezia furfur, the causative agents of several ringworms (Trichophyton, Epidermophyton floccosum, Microsporum), the causative agents of candidiasis (Candida), and also the causative agents of systemic mycoses (Cryptococcus).
Also active against gram-positive cocci: Staphylococcus spp., Streptococcus spp.

Pharmacokinetics of Clotrimazole ointment

Ketoconazole is a weak dibasic compound that dissolves and is absorbed in an acidic environment. Cmax of ketoconazole in plasma is about 3.5 µg / ml and is achieved within 1-2 hours after a single oral dose of 200 mg during a meal. The bioavailability of ketoconazole is maximized when taken with food. Absorption of ketoconazole is reduced in patients with low acidity of gastric juice, for example, taking antacid drugs, such as aluminum hydroxide, and antisecretory drugs, such as histamine H2-receptor blockers and proton pump inhibitors, as well as in patients with achlorhydria caused by the disease.
Plasma protein binding, mainly with the albumin fraction, is 99%. Ketoconazole is widely distributed in the tissues, but only a small part of the drug penetrates into the cerebrospinal fluid.
After absorption from the gastrointestinal tract, ketoconazole is metabolized in the liver to form a large number of inactive metabolites.
In vitro studies have shown that CYP3A4 isoenzyme is involved in the metabolism of ketoconazole. The main metabolic pathways are the oxidation and cleavage of the imidazole and piperazine rings, oxidative O-dealkylation and aromatic hydroxylation. Ketoconazole is not an inducer of its own metabolism. Removal from plasma is biphasic: during the first 10 hours, T1 / 2 is 2 hours, subsequently - 8 hours.
About 13% is excreted in the urine, of which 2–4% is unchanged. Excreted mainly with bile in the digestive tract and about 57% excreted in the feces.


    Fungal diseases of the skin, mikozy skin folds, feet;
    pityriasis versicolor, erythrasma, superficial candidiasis caused by dermatophytes, yeast (including the genus Candida), mold and other fungi and pathogens sensitive to clotrimazole ointment;
    mycoses complicated by secondary pyoderma.


Hypersensitivity to Clotrimazole ointment, I trimester of pregnancy.

special instructions for Clotrimazole ointment

To prevent the spread of urogenital infections requires simultaneous treatment of sexual partners. When trichomoniasis for a more successful treatment in conjunction with ointment clotrimazole should be prescribed other drugs that have a systemic effect (for example, metronidazole inside).
Vaginal tablets are not recommended during menstruation.
In the case of an unintended method of using the drug (orally), the following symptoms are possible - anorexia, nausea, vomiting, gastralgia, abnormal liver function, rarely drowsiness, hallucinations, pollakiuria, skin allergic reactions. In these situations, it is necessary to take activated charcoal and consult a doctor.
If you develop allergic reactions or irritation, treatment should be stopped and another therapy should be selected.
In case of ringworm, it is recommended to apply the solution after each washing of the feet.
It is not recommended to apply the drug on the skin in the eye area.
If after 4 weeks from the start of treatment no clinical improvement is noted, it is necessary to confirm the diagnosis microbiologically and exclude another cause of the disease.


1 g ointment contains:
Active ingredient: clotrimazole;
Excipients: propylene glycol, nipagin, succinic acid, sodium benzoate, emulsifier No. 1 or emulsifier EM 3398, castor oil, methylcellulose soluble in water or methylcellulose SM100, monoglycerides distilled, purified water.

Dosing and Administration

When applied topically applied to the affected skin 2-3 times a day for 2-4 weeks.
When processing the oral cavity is used 1-2 times a day for no more than 7 days.
Intravaginal - 100-500 mg for 1-6 days.

Side effects

Local reactions: contact allergic dermatitis, redness, burning sensation.

Drug interaction

Reduces the effect of polyene antibiotics (amphotericin, nystatin, natamycin, etc.). Para-hydroxybenzoic acid propyl ester in high concentrations enhances the antifungal effect of clotrimazole ointment, and dexamethasone reduces it.
With simultaneous use with nystatin, clotrimazole ointment activity may be reduced.

Storage conditions

In the dark place at a temperature below 25 ° C.
Shelf life - 3 years.

Terms of sell

You don't need a prescription to buy Clotrimazole ointment.

Write a review

Please login or register to review

Sign Up for Newsletters