Gynofort cream 20mg/gr 5gr

Gynofort instruction for use

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Composition

1 gram of cream contains 20 mg of butoconazole nitrate.
Additional: 399.78 mg sorbitol, 80.32 mg mineral oil, 27.13 mg glyceryl monostearate, 27.13 mg polyglyceryl-3-oleate, 4.52 mg of wax, 50 mg of propylene glycol, 10.13 mg of colloidal silica dioxide, 1.8 mg of methyl parahydroxybenzoate, 0.5 mg of disodium edetate, 0.5 mg of propyl parahydroxybenzoate , 378.19 mg of water.

Form of issue

The medicine Gynofort is made in the form of a vaginal cream of 5 grams in a polypropylene applicator placed in a polysterene box packed in a laminated bag in a cardboard bundle.

pharmachologic effect

Local antifungal (antimycotic).

Pharmacodynamics and pharmacokinetics

Gynofort cream is an antimycotic drug used in gynecologists for topical treatment of fungal vaginal infections.
The imidazole derivative, Butoconazole, is characterized by its fungicidal action directed to fungal strains of the genus Candida (thrush), Trichophyton (trichophytosis), Microsporum (ringworm), Epidermophyton (epidermophytia). The effectiveness of the drug is manifested by its ability to block the transformation of lanosterol into ergosterol in the cell fungal membrane and increase the permeability of the membrane itself, thereby leading the fungal cell to lysis (decay).
The bioadhesiveness of the vaginal cream is at a high level. With a single intravaginal (in the vagina) way of using the drug, its active ingredient - butoconazole is present on the vaginal mucosa for 4-5 days.
Systemic absorption of butoconazole with its intravaginal administration is 1.7% of the dose used. The plasma Cmax values ​​are 2-18.6 ng / ml and are reached after 13 hours after the introduction of the drug into the vagina.
In the body, butoconazole undergoes intensive metabolic changes and, in the final analysis, is partially excreted by the kidneys and intestines.

Indications for use

Gynofort Cream is indicated for local therapy of vaginal candidiasis (thrush) caused by a fungus strain of Candida albicans.

Contraindications

Gynofort is contraindicated in patients with personal hypersensitivity to butoconazole or other cream ingredients, girls and girls under the age of 18 (lack of data on efficacy / safety), and pregnant and lactating women.

Side effects

Occasionally, after intravaginal administration of the cream, appearance of passing negative local phenomena was observed, manifested by: burning, soreness, itching, edema of the vaginal walls, spasms and / or pains in the lower abdomen.

Gynofort cream, instructions for use (Method and dosage)

Unlike other local medicines intended for the treatment of vaginal candidiasis (including suppositories, tablets, pessaries, etc.) and used repeatedly, Gynofort therapy requires its single intravaginal application. The contents (about 5 grams of cream) of one applicator should be inserted deep into the vagina, regardless of the time of day. In case of ineffectiveness of a single use of the drug and persistence of the symptomatology of the disease, the patient must undergo a second mycological examination to confirm or refute the previously diagnosed diagnosis.

Instructions for the application of Gynofort in the applicator

The applicator of this medication is intended for single use. Do not heat the applicator before using it, and use the applicator with the protective cap removed earlier.
For the correct administration of the drug, a number of the following manipulations must be carried out, namely:
    remove the applicator from the pencil case by removing the packaging foil from it;
    without removing the special protective cap from the applicator, pull its piston to the limit, pulling a hand for a special ring;
    remove the protective cap from the applicator and gently insert it into the vagina as deeply as possible;
    gently pushing the piston completely to displace the cream from the applicator;
    Remove the used applicator from the vagina, close the cap and discard.

Overdose

At this time, episodes of overdose with local use of Gynofort cream have not been reported. In case of accidental ingestion (swallowing) of the contents of the applicator, it is necessary to clean the gastrointestinal tract (gastric and intestinal lavage) and prescribe symptomatic therapy.

Interaction

In connection with the inclusion of a mineral oil in the cream that can damage rubber and latex products, including intravaginal diaphragms and condoms, the use of these contraceptives should be avoided for a minimum of 72 hours after the introduction of Gynofort.

Storage conditions

Cream from the yeast infection Gynofort must be stored in the original packaging at an ambient temperature of 15-25 ° C.
Shelf life - 3 years.

special instructions

If clinical signs of infectious mycosis damage persist after treatment, the patient must undergo a second examination in order to identify the pathological agent of the disease and confirm or deny the previously diagnosed disease.
Accidental ingestion of the cream requires taking measures to cleanse the digestive tract (washing the stomach and intestines) and performing symptomatic treatment.
When there are painful sensations in the vagina or irritation of its mucous membrane against the background of Gynofort application, it is necessary to stop further use of this medication.
Due to the inclusion of parabens in the preparation that can cause allergic reactions, its use requires caution.

Children

The use of Gynofort in pediatrics is contraindicated.

Gynofort during pregnancy and lactation

The official instruction for the use of Gynofort prohibits the use of cream for the treatment of thrush in pregnant and lactating women, however, in gynecological practice, the appointment of this drug in these periods is quite common.
Many women are often acutely aware of the negative manifestations of vaginal candidiasis during pregnancy and, fearing to harm their future child, continue to live with this ailment until the very birth. Such a decision can not be called absolutely correct, since changes in the flora of the vagina, a sense of discomfort and, finally, the possibility of infection of the child during labor is a signal for the need to get rid of thrush.
Naturally, the decision to appoint a particular remedy in this case can only be taken by the treating doctor and gynecologist, after carefully choosing the time for the treatment and explaining all the possible consequences of such therapy to her patient.
Considering the cases of Gynofort application by pregnant women, it is possible to pay attention to rather favorable results of such treatment. Reviews during pregnancy about the effectiveness and safety of the cream of this drug are mostly positive, and a fairly long experience of using Gynofort during this period can serve as a recommendation to consider the question of its use.

Reviews about Gynofort

In the practice of vaginal candidiasis treatment, Gynofort cream is one of the important places, doctors' reviews, as well as those who apply it, are overwhelmingly positive, including reviews about it during pregnancy. High cream efficiency, minimal side effects of treatment along with its single use, make this drug very popular, and its only negative point is its impressive cost.