Iprozhin caps 200mg #15

Iprozhin user manual

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Composition

In 1 capsule of progesterone, 200 mg or 100 mg.

Form of issue

Capsules number 30 and number 15.

pharmachologic effect

Substitutive, hormonal.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The active substance of the drug is progesterone. It binds to receptors, activates DNA and stimulates the synthesis of RNA. Under the influence of progesterone, the uterine mucosa passes from the stage of proliferation into the phase necessary for the attachment of a fertilized egg. After fertilization and development of the embryo reduces the excitability of the uterus and creates the necessary conditions for the bearing of the fetus. After the birth of the child induces lactation. In parallel, it contributes to the increase in fat stores and the level of insulin, in high doses inhibits the production of gonadotropic hormones.

Pharmacokinetics

After oral intake absorbed into the gastrointestinal tract and after 1-3 hours Cmax is reached in the blood. It binds to proteins by 90%. Metabolised in the liver. It is excreted by the kidneys. When intravaginal use in the plasma is determined after 1 hour, and Cmax is achieved in 3-6 hours.

Indications for use

Application Iprozhin inside is shown when:
    premenstrual syndrome;
    mastopathy;
    pre-menopause;
    postmenopausal (as hormone replacement therapy in combination with estrogens).

Intravaginal:

    Support luteal phase in the IVF protocol;
    hormonotherapy with missing ovaries;
    the threat of premature delivery;
    premature menopause (in combination with estrogens);
    endocrine infertility;
    prevention of a threatening miscarriage;
    prevention of fibroids;
    endometriosis.
Iprozhin during pregnancy is allowed to use in the I-II trimester. Nevertheless, it should be used with caution in connection with the risk of liver dysfunction.

Contraindications

    hypersensitivity;
    propensity to thrombosis;
    bleeding from the vagina of an unexplained etiology;
    acute phlebitis;
    incomplete abortion;
    violations of the liver (for oral administration);
    neoplasm of mammary glands.
With caution is prescribed for diseases of SSS, arterial hypertension, diabetes mellitus, chronic renal failure, bronchial asthma, depression, epilepsy.

Side effects

    drowsiness;
    allergic reactions;
    dizziness (pass through 2-3 hours);
    intermenstrual bleeding;
    cycle reduction.

Iprozhin, instructions for use (Method and dosage)

It is recommended to take Iprozhin inside before going to bed.
With mastopathy, dysmenorrhea, premenstrual syndrome appoint 200-300 mg for 10 consecutive days from 17 to 26 day cycle.
In post-menopause, together with the use of estrogens, Iprozhin 200 mg is recommended for 10-12 days.
The drug is produced only in a dosage form - capsules, which are also designed for topical application (intravaginally). The name of the Iprozhin candle is incorrect. Intravaginal capsules are used in the following cases.
To support the luteal phase with IVF - prescribe 400-600 mg per day, after the injection of XG and up to 12 weeks of pregnancy.
When donating eggs - Iprozhin is used 100 mg per day for 13 and 14 days of the cycle, from 15 to 25 days for 100 mg 2 times a day, from 26 days (or with pregnancy), the dose increases every week by 100 mg.
When infertility is used 200-300 mg per day, 10 days from the 17th day of the cycle.
When a threat of abortion is recommended, 100-200 mg twice daily, every day, until the 12th week of pregnancy.
The drug is not used for contraception.

Overdose

In case of an overdose, side reactions increase and disappear when the dose decreases.

Interaction

Simultaneous reception with barbiturates, phenytoin, phenylbutazone, rifampicin, spironolactone causes acceleration of progesterone metabolism.
Strengthens the effect of anticoagulants, diuretics, hypotensive drugs.
Simultaneous reception with penicillins and tetracyclines leads to a decrease in the effectiveness of the active substance.
Progesterone increases the concentration of cyclosporine and ketoconazole. Reduces tolerance to glucose, so it is necessary to increase the dose of hypoglycemic drugs and insulin in patients with diabetes mellitus.
Ketoconazole increases the bioavailability of the drug. Bioavailability decreases in smokers and in alcohol consumption.

Storage conditions

The temperature is 15-25 ° C.
Shelf life - 3 years.

Reviews about Iprozhin

This drug is used for diseases or conditions in which progesterone deficiency is noted. Progesterone is called the hormone of pregnancy, as it creates the necessary hormonal background in preparation for conception, promotes pregnancy, prevents spontaneous miscarriages and premature birth. What is the probability of getting pregnant when you drink Iprozin? If there is an indication for prescribing the drug and it is prescribed correctly (in the appropriate dose and according to the scheme), the goal will be achieved. After conception, you need to continue receiving until the end of the first trimester.
Many women note the presence of side effects when taking the drug inside: weakness, drowsiness during the day, increased blood pressure. At the same time, it is noted that there are no adverse reactions with intravaginal application. If the doctor considers it possible to use this method of application for your disease, then it is worth giving it a preference.
The question is often asked: Iprozhin or Utrozhestan - what is better? Preparations are identical in composition, dosage, indications for use and cost. Both drugs contain natural progesterone. Differences consist only in the manufacturer and in the capsule. Gynecologists insist on the intake of natural hormones in the planning and preservation of pregnancy, and synthetic progesterone is often used to treat diseases (elimination of PMS, menopausal symptoms).
Women share their impressions of the use of both drugs. Many believe that Utrozhestan better, because it has no oily basis, so it does not flow from the vagina. In addition, according to their observations, he rarely causes thrush and is much better tolerated.
    "... Iprozhin practically does not follow intravaginal application, so I think that it is more effective. And it also dissolves better and faster. "
    "... Utrozhestan flows both in a standing and lying position! Terribly uncomfortable at work. "
    "... I did not notice a strong difference, but it really does not flow. Iprozhin was the victorious protocol. "
    "... I had a bad feeling from Utrozhestan".