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Pragisan caps 200mg #10

  • $16.56
  • 3 or more $16.30
  • Availability:In Stock

Instruction for PragisanReed more about Pragisan and buy it hereCompositionOne tablet of the preparation Pragisan contains 100 or 200 mg of active ingredient progesterone + auxiliary substances (soy lecithin, glycerol, peanut oil,..

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Instruction for Pragisan

Reed more about Pragisan and buy it here


One tablet of the preparation Pragisan contains 100 or 200 mg of active ingredient progesterone + auxiliary substances (soy lecithin, glycerol, peanut oil, water, sorbitol solution, gelatin, titanium dioxide).
Vaginal gel contains 80 mg of progesterone per 1 gram of preparation + sorbic acid, guar gum, liquid paraffin, hypromellose K100M, glyceride of hydrogenated palm oil, water.

Form of issue

The medicine is released in the form of gelatin capsules, 10 tablets in a blister, 1 or 3 blisters in a cardboard bundle. Capsules are oval, light yellow. Inside is a white oily suspension.
Also, the drug is sold as a white vaginal gel, soft, homogeneous, in packages of 1.35 grams, one tube in a pack.
Also, the agent is released as an oil solution.

pharmachologic effect


Pharmacodynamics and pharmacokinetics

The drug is a hormone of the yellow body. The hormone is able to penetrate the nucleus of target organs and stimulate the synthesis of RNA, activate DNA.
Pragisan translates the uterine mucosa into a phase of secretion from the proliferative phase. Thus, specific conditions are created for implantation of a fertilized egg. The musculature of the uterus relaxes, the organ becomes less sensitive to the action of Oxytocin.
The active substance stimulates lipoprotein lipases, increases fat stores, activates the process of inducing Insulin, the production of Aldosterone.
When the gel is applied to the mammary gland, the proliferation and mitotic activity of the epithelium in the ducts decreases. When ingestion decreases the permeability of the capillaries of the tissues of the mammary glands, edema of the connective stroma subsides.
The medicine is quickly and almost completely absorbed. Maximum concentration is achieved within two hours. High degree of binding of the hormone to blood plasma proteins. The drug undergoes metabolic reactions in the liver tissues. A remedy is shown with bile and kidneys, with feces.
With vaginal use of the drug, the active ingredient accumulates in the uterus, the maximum concentration of the substance is already found in the blood plasma within an hour after administration.

Indications for use

The agent is prescribed for various disorders associated with a deficiency of the hormone progesterone in the body.

Capsules accept:

    with premenstrual syndrome;
    if there is a violation of the menstrual cycle due to anovulation and ovulation;
    with fibrocystic myopathy;
    during premenopause;
    when using hormone replacement therapy perimenopause and postmenopause.

The medicine is prescribed topically:

    as a replacement hormone therapy with a deficiency of progesterone;
    during preparation for extracorporeal fertilization for luteal phase prolongation;
    at the onset of early menopause;
    for the treatment of infertility, due to the non-occurrence of the luteal phase;
    for the prevention of abortion with hormonal imbalance;
    as a prophylactic for uterine myoma or endometriosis.


The medicine is not prescribed:
    patients with disorders in the blood circulation of the brain, thromboembolic disorders, including in the anamnesis;
    with thrombophlebitis;
    patients with porphyria;
    Persons suffering from liver or kidney disease;
    if there is a suspicion or presence of malignant neoplasms of the mammary glands or genitals;
    Persons with allergy to the components of the product;
    when bleeding from genital organs of unknown origin;
    after incomplete abortion.
The solution in oil is not prescribed for the 2nd and 3rd trimester of pregnancy, the propensity to form blood clots.

Side effects

Of all the possible side effects, the most common allergy occurs.
Adverse reactions from taking tablets and ointments:
    tension and swelling of the mammary glands;
    the onset of menstruation ahead of time;
    drowsiness, dizziness, nausea;
    headaches, jaundice, swelling and fluid retention in the body;
    a decrease in working capacity, rashes on the skin, anaphylactic shock.

For a solution in oil, the following can develop additionally:

    increased blood pressure, cholecystitis, hepatitis, visual impairment;
    thromboembolism, decreased sexual activity;
    pain in the injection site.

Instructions for the use of Pragisan (Method and dosage)

Duration of admission and dosage should be determined by the attending physician, depending on the disease.

Instruction on Pragisan in capsules

Inside, squeezed a lot of liquid.
As a rule, appoint 200 to 300 mg of the drug, dividing them into 2 doses.
With premenstrual syndrome, dysmenorrhea, fibrocystic mastopathy, during premenopause the recommended dosage is 200-400 mg per day. The course of treatment lasts from 10 to 12 days.
When the vaginal route of administration of the capsule or cream, they are injected deep into the vagina.
During the preparation for the donation of eggs and women with testicles prescribed 200 mg per day, 13 and 14 days of the menstrual cycle, from 15 to 26 days - 100 mg. In case of pregnancy, the dosage is increased by 100 mg per day every week, after reaching the level of 600 mg per day, the dosage is divided into 3 doses. The maximum dosage of 600 mg can be taken no more than 2 months.
In order to maintain the luteal phase in preparation for IVF use 200-600 mg per day, during the first and second trimesters of pregnancy.
When a threat of abortion or in order to prevent abortion due to a lack of hormone progesterone in the body is prescribed for 200-400 mg every day, for 2 admission, in the 1st and 2nd trimester of pregnancy.

Gel Instruction

    Open the package with the applicator.
    Disconnect the cap.
    The applicator is located between the middle and big fingers, press the index finger on the piston.
    A woman needs to take the position of "lying on her back", slightly bend the knees.
    Slowly insert the applicator into the vagina, press the plunger.
    Discard the used applicator with gel residues.


Signs of an overdose are: dizziness, drowsiness, a shortened menstrual cycle.
As a therapy, it is recommended to switch to the vaginal route of administration of the agent, to adjust the dosage. Take medicine immediately before bedtime. If there is a shortening of the menstrual cycle, the medicine can be taken 2-3 days later than usual.


When the drug is combined with carbamazepine, rifampicin, barbiturates or hydantoin, the efficacy of the agent may be reduced.
Also, Griseofulvin and enterosorbents can reduce the effectiveness of the drug.
With caution, the drug is combined with Trolandomycin, Theophylline and Cyclosporin.
With the intravaginal route of administration, the drug should not be combined with various suppositories and vaginal pills.

Storage conditions

Tablets are stored at a temperature of no higher than 25 degrees in a cool, dry place.
Gel - at a temperature of 15 to 25 degrees.
Keep away from children.
Shelf life- 2 years.

special instructions

When taking the drug should be careful to people suffering from cardiovascular disease or with depression, including in the history.
The medicine can not be used to protect against unwanted pregnancy.
With prolonged and systematic use of funds, it is necessary to monitor the blood counts, the work of kidney baking. Increased chances of development of chloasma, should limit exposure to sun and exposure to ultraviolet light.
When using progesterone inside, you should use caution when driving.


There are the following analogs of this drug: Iprozhin, Progestogel, Utrozhestan.

Pragisan during pregnancy and lactation

The medicine is allowed to be used in the early stages, after consultation with the attending physician. Pragisan during pregnancy is prescribed in the framework of assisted methods of reproduction.
There is not enough evidence to assess the risk to the fetus when taking the medication while breastfeeding. It is recommended to consult a doctor.

Reviews about Pragisan

On the Internet, basically good reviews about the drug, if you use it in accordance with the recommendations of a doctor.
Reviews about Pragisan in the forums:
    "I took the drug to get rid of the pain before the menstruation. The medicine greatly eased all my pains. I advise you to buy ... "
    "After taking the first pill, it became bad, my head was spinning, I felt sick, and there was a vacuum in my ears, I was feeling sick all day ..."
    "My sister drank pills during pregnancy. Brought and gave birth, everything is in order ... "

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