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Cortexin powder for inj. 10mg #10

rating
  • $48.41
  • 2 or more $47.50
  • 3 or more $46.90
  • Availability:In Stock

Cortexin user manualYou can buy Cortexin hereCompositionThe composition of a lyophilized powder contained in a single bottle for the preparation of an injection contains 5 or 10 mg of a complex of water-soluble polypeptide fractio..

Tags: powder, nootropic

Cortexin user manual

You can buy Cortexin here

Composition

The composition of a lyophilized powder contained in a single bottle for the preparation of an injection contains 5 or 10 mg of a complex of water-soluble polypeptide fractions (cortexin) as an active substance and 6 or 12 mg of glycine as a stabilizer.

Form of issue

The drug is available as a sterile lyophilized powder for the preparation of a solution for intramuscular injection.
Cardboard packaging is completed with two contour cellular packs, each containing 5 vials of lyophilizate, and guidance for use.
In pharmacies, you can buy Cortexin 10 mg No. 10 and Cortexin 5 mg No. 10.
Cortexin 10 mg is available in 22 mg in 5 ml bottles. The drug is intended for the treatment of adult patients.
Cortexin 5 mg is specifically formulated for pediatric use. It is available in 11 g bottles with a capacity of 3 ml.

pharmachologic effect

Cortexin belongs to a group of nootropic and hamkergic drugs that primarily affect the central nervous system. Against the background of its use, it is noted:
    nootropic;
    neuroprotective;
    antioxidant;
    tissue-specific effects.

Pharmacodynamics and pharmacokinetics

Cortexin is a bioregulator with a polypeptide structure, which is a complex of water-soluble neuropeptides. The molecular weight of these polypeptide fractions does not exceed 10,000 daltons, which allows them to penetrate the physiological barrier separating the central nervous and circulatory systems.

The mechanism of action of the drug is realized by:

    activation of regulatory peptides, neurons and brain neurotrophic factors;
    normalization of the ratio of amino acids that perform the mediator functions of the exciting and inhibitory types of action, as well as important neurotransmitters of the brain of dopamine and serotonin;
    moderately expressed GABA-ergic effect;
    reduce the level of paroxysmal (paroxysmal) convulsive activity of the brain and the ability to normalize the indices of its bioelectrical activity;
    preventing the formation of products of oxidative degradation of lipids (free radicals).
Nootropic action of Cortexin is accompanied by improvement of higher brain functions, memory improvement, increased learning ability and stress resistance.
The neuroprotective effect is manifested in the ability of the drug to increase the resistance of brain tissue to the damaging effects of various endogenous neurotoxic factors and to reduce the toxic effects of neurotropic substances.
The antioxidant effect is manifested in the ability of the drug to affect oxidative stress (cell damage provoked by oxidative processes) and to increase the survival rates of neurons in conditions of oxygen starvation.
The mechanism of this action is associated with the suppression of free radical processes and lipid peroxidation of cell membranes, as well as with correction of oxygen-dependent pathological conditions.
As a result: the process of destruction of cell membranes is slowed down, microcirculation improves, the permeability of the vessel walls decreases, the level of cholesterol and triglycerides in the blood is normalized.
Tissue-specific effect of the drug is associated with an increase in the intensity of metabolism of neurons of the central nervous system and PNS, stimulation of reparative processes in the central nervous system, improvement of the functional state of the cortex of the cerebral hemispheres and the general tone of the somatic and autonomic nervous system.
Pharmacokinetic characteristics can not be determined, since the decay time of the amino acids of the L-series and neuropeptide fractions in the active ingredient Cortexin is no more than 3 minutes.
This makes it impossible to establish the rate and degree of absorption of peptide residues, their distribution to various organs and tissues, as well as the rate and ways of their excretion from the body.

Indications for use of Cortexin: what is the drug prescribed for adults and children

Indications for the use of the drug are:
    Infectious diseases of the nervous system, provoked by bacteria or viruses;
    states, accompanied by a violation of blood circulation in the brain;
    IMT and its consequences;
    syndrome of diffuse lesions of the brain of different origin;
    cerebral (nadsegmental) vegetative disorders.
In combination with other drugs, the drug is prescribed for the treatment of epilepsy, as well as for the treatment of acute and chronic inflammatory diseases of the brain and / or spinal cord of various etiologies.
For children, indications for the use of Cortexin are a reduced ability to learn, memory and thinking disorders, a delay in the child's psychomotor and speech development (CPRD), various forms of cerebral palsy.

Contraindications

The drug is contraindicated in patients with hypersensitivity to cortexin and / or glycine.
Clinical studies to determine the effect of the drug on the body of a pregnant woman and a developing fetus were not conducted. For this reason, the drug is not recommended for use at any time of pregnancy.
Since there are no clinical studies regarding the use of the drug during breastfeeding, it is recommended that breastfeeding be discontinued if it is necessary to prescribe Cortexin.

Side effects of the drug

A potentially possible side effect is allergic reactions due to individual sensitivity to the ingredients in the formulation.

Cortexin injections, instructions for use (Method and dosage)

The drug is intended for insertion into the muscle.

How to breed Cortexin?

Before injection, the powder contained in the vial should be diluted with one or two milliliters of 0.5% solution of procaine (novocaine), saline (isotonic sodium chloride solution (0.9%)) or water for injection.
To prevent the formation of foam, the needle is then directed to the wall of the bottle.

How to stab a child Cortexin?

Cortexin is allowed to be administered from the first days of life. In some situations, parents have to do the child themselves. And here there are questions how correctly to make an injection of Cortexin and the better to plant the powder.
Before injecting, inject water, novocaine or saline into the syringe, then pierce the vial lid and pour in the collected liquid.
The syringe should be removed (the needle remains in the lid) and shake the contents of the vial thoroughly until the powder is completely dissolved. After that, the syringe is reattached and the necessary amount of solution is poured into it.
For a prick, it is better to take a new needle, because the needle that was injected with the solvent for the lyophilizate can already be fairly blunted.
The medication is administered slowly, since a rapid injection can provoke very severe pain.
Babies up to six months of intramuscular injection is done in the front of the thigh (to not accidentally damage the sciatic nerve).
Children, especially very small, all injections are done in physiological saline or water for injection. The injections with novocaine are less painful than injections on saline, however, it is only possible to dilute the drug with novocaine if there is a firm belief that this will not cause an allergic reaction in the baby (Novocain is able to give the strongest allergies and seizures).
Like other neuro-metabolic drugs, Cortexin is recommended to stab up to 12 pm, given its activating effect and the ability to provoke psychomotor agitation.

Instructions for use Cortexin for adults

For adults, injections of Cortexin are done once a day, daily for ten days, at a dose of 10 mg.
In case of massive ischemic stroke (MI) in the acute phase, as well as in the early recovery period, the indicated dose is recommended to be administered twice a day (morning and evening) to the patient for ten days. Ten days later, the course should be repeated.

Instructions for use Cortexin for children

In pediatric practice, the medication is used to treat children from the first days of their life.
Patients whose weight does not exceed 20 kg, the drug is prescribed in a dose equal to 0.5 mg / kg of body weight. Patients weighing more than 20 kg show a dose of 10 mg.
Duration of treatment is ten days. If necessary, after three to six months, the patient may be assigned a second course.
The drug rarely causes side effects, has almost no contraindications and can be used to treat even newborn babies. Its main drawback is the form of the release: Cortexin is not available in tablets, and this in part complicates its use in children, if the latter requires several courses.

Overdose

To date, there are no reports of side effects that have developed due to an overdose of Cortexin.

Interaction

The drug is incompatible with drugs that have a peptide structure.

Storage conditions

Cortexin should be stored in dry, sheltered from sunlight at a temperature of 2 to 20 ° C.

Shelf life

It is suitable for use within 36 months from the date of manufacture.

special instructions

The drug is produced exclusively in the form of lyophilizate, Cortexin is not produced in tablets.
The drug should not be mixed in one syringe with any other medicines.

Cortexin for children

Instructions for use Cortexin for children allows the use of this drug from the first days of life.
The doctors' comments on Cortexin for children confirm the manufacturer's statements that the drug practically does not cause adverse reactions, allergies, does not have a teratogenic and carcinogenic effect and is well tolerated by patients.
Its application in neurology, neonatology and pediatrics makes it possible to improve the behavior of the child and his general condition with various kinds of tonus, normalize the function of memory and speech, and remove headaches.

Reviews about Cortexin

Cortexin is a drug widely used in neurological practice. Reviews about Cortexin for adults, which can be found in numerous thematic forums, indicate the effectiveness of this tool for treating patients of different ages (both for infants and the elderly).
Taking the drug can accelerate the recovery process after the trauma and stroke, and in the elderly stimulates the brain, increases the ability to remember and focus, and also prevents the reduction of intellectual abilities.
Reviews of Cortexin for children allow us to conclude that the drug is most often prescribed to children who have some deviations in neuropsychological development. In particular indications for the use of the drug are cerebral palsy and brain lesions that occurred during the prenatal period (close to the date of birth) or directly in the process of childbirth.
The injections to the children - and the testimonies about Cortexin confirm this fact - make it possible to achieve significant improvements: after the course of treatment with the drug, the child becomes calmer, he has improved brain activity, increased interest in learning, memory and speech improve.
The use of the drug for infants (in particular, for newborns that were born before the due date) makes it possible to notice, in a rather short time, obvious improvements that are manifested in the child's calmer behavior or the appearance of new skills (for example, the ability to turn from one's back to the tummy and back).
Moms, whose children were prescribed Cortexin, note that after the course of treatment the child literally "came to life before our eyes." Many people consider the advantages of the drug as the absence of side effects and low toxicity of the drug. As a minus most often indicate a fairly high price of the remedy and painful nyxes.
As for the doctors' comments about Cortexin, they, despite the rather high evaluation of the drug on the forums (on average 4.1-4.3 on a 5-point scale), are quite contradictory: some doctors consider it a panacea, others - a pacifier with unproven effectiveness .

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