Memantin tabs 10mg #90

Memantin instruction for use

You can buy Memantin tablets here

Composition

The drug contains Memantin hydrochloride as the main component.

Form of issue

The drug can be sold in the form of a substance-powder and tablets.

pharmachologic effect

This drug has antispastic, antiparkinsonian and neuroprotective effect.

Pharmacodynamics and pharmacokinetics

The drug is an NMDA receptor blocker. It inhibits the effect of elevated glutamate levels and, as a result, prevents the disruption of neuronal function. Improves mental activity and normalizes motor impairment.
The maximum content in the blood plasma is observed after about 3-8 hours. Meals do not affect absorption. Bioavailability of the drug is approximately 100%.
At doses of 10-40 mg, the pharmacokinetics are characterized by linearity. About 45% of the active substance binds to blood plasma proteins. Approximately 80% is circulating in the original form.
It is excreted mainly through the kidneys. The half-life is 60-100 hours. The rate of excretion may decrease by 7-9 times in the case of urine alkalinization. This can happen because of cardinal changes in the diet. For example, if earlier he was rich in meat dishes, and then there was a sharp transition to the vegetarian menu. In addition, this effect is possible due to the use of antacid preparations.

Indications for use

The drug is used in dementia and Alzheimer's disease in various forms. In addition, it is used for spinal and cerebral spastic syndrome, problems with the functions of the nervous system, parkinsonism, Parkinson's disease.

Contraindications

Do not use this product with increased sensitivity to its components, confusion, breastfeeding, significant violations of kidney function, pregnancy.

Side effects

As a rule, the following undesirable effects that may be associated with the use of the drug are noticeable: confusion, hallucinations, dizziness, fatigue, headache, anxiety, vomiting, increased libido, increased muscle tone, cystitis. In addition, occasionally reported epileptic seizures. Usually this happens if there was a convulsive syndrome earlier.

Instructions for use Memantin (Method and dosage)

Instruction for Memantin reports that it is intended for oral use. It is advisable to start treatment with minimal dosages, which are selected individually. The starting daily dose for adult patients is 5 mg. If necessary, it can be increased by 5 mg every week. The recommended maintenance dosage is 10-20 mg per day. It can be increased to 60 mg. If there are problems with kidney function, the dosage should be reduced.
Instructions for use Memantin for children recommends giving 0.5 mg per kg of body weight every day. In case of problems with the kidneys, the drug should be taken under the supervision of their functional state.
It is advisable to refuse at the time of taking the medicine from the management of vehicles, servicing mechanisms and other activities in which increased attention is needed.

Overdose

When using the drug in high doses, there may be anxiety, visual hallucinations, drowsiness, loss of consciousness, psychosis, convulsive alertness, stupor. Therapy is symptomatic.

Interaction

The drug affects the effect of dopaminergic receptor agonists, neuroleptics, barbiturates, anticholinergics, amantadine, levodopa. In addition, it can alter the action of Baclofen and Dantrolene. So you may need to adjust their dosages.
It is not recommended to take simultaneously with phenytoin. And interaction with drugs containing hydrochlorothiazide can lead to a decrease in the latter in the blood plasma.
It is necessary to avoid the combination of the drug with N-methyl-D-aspartate antagonists. Otherwise, it can trigger the appearance of side effects.

Storage conditions

The storage temperature must be up to 25 ° C. Keep this product in a place inaccessible to young children.
Shelf life - two years.

Reviews of Memantin

The doctors' comments on Memantin indicate that the drug is effective enough if used according to the indications. It helps patients with dementia and other diseases, when used strictly in accordance with the appointment of a specialist. Patients leave comments about Memantin infrequently, but there are no negative ones among them.