Noojerone tabs 10mg #60

Noojerone user manual

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Composition

In 1 tablet of Noojerone contains 10 mg of active substance - memantine hydrochloride, which is equivalent to 8.31 mg of memantine.
The tablets are coated with an Opadry II shell of gray color No. 45F27505, consisting of hypromellose (2.5 mg), polydextrose (2.5 mg), titanium dioxide (2.48 mg), macrogol (0.5 mg) and ferrous iron oxide 0.02 mg).
Among other excipients, 136.8 mg of MCC, 84.5 mg of calcium hydrophosphate, 4.8 mg of croscarmellose sodium, 1.5 mg of colloidal silicon dioxide and 2.4 mg of magnesium stearate were used.

Form of issue

Noojerone - a tablet in a film shell, an oval biconvex form, gray. There is an engraving "10", divided by a risk on one of the sides, as well as engraving "MM" and the risk between the letters - on the other. In one cardboard bundle there can be 30, 60, 90 tablets packed in blisters of 10 tablets.

pharmachologic effect

Noojerone has a psychometabolic and nootropic effect.

Pharmacodynamics and pharmacokinetics

The active substance memantine is an antagonist of glutamate NMDA receptors (N-methyl-D-aspartate) of a noncompetitive type and is able to reduce the excessive stimulating effect of cortical neurons in relation to neostriatum, which develops against a background of lack of dopamine release, has an effect on rigidity, as well as bradykinesia .
By reducing the intake of Ca ions into neuron cells, the level of their destruction decreases. Thanks to nootropic action, weakened memory improves, concentration of attention increases, fatigue decreases and the manifestations of depression stop.

Pharmacokinetics

Absorption fast and complete, regardless of food intake, reaches a maximum concentration after 3-8 hours. Binding occurs with proteins at 45%. The exchange does not require the participation of cytochrome P 450. The main metabolites are presented as 2 isomers of N-3,5-dimethylglutanate and 1-nitroso-3,5-dimethyl-adamantane, which do not possess pharmacological activity.
Excretion occurs through the kidneys in a single phase with a half-life of up to 100 hours at a clearance of 170 ml per minute.

Indications for use of Noojerone

Indication for use is dementia, that is, acquired dementia in the middle or severe phase of Alzheimer's disease.

Contraindications

    hypersensitivity to any component of the drug;
    severe forms of hepatic and renal insufficiency;
    pregnancy and breastfeeding;
    patients under the age of 18 years.
Precautions are prescribed for epilepsy, thyrotoxicosis, myocardial infarction and history of seizures, arterial hypertension, heart failure.

Side effects

With the therapy of Noojerone from the side of various systems, the following adverse reactions were observed:
    Nervous system: dizziness, headaches, drowsiness, confusion, convulsions, psychosis, hallucinations, increased excitability.
    Digestive: constipation, nausea, vomiting, pancreatitis.
    Cardiovascular: increased blood pressure, venous thrombosis and thromboembolism.
    Other: asthenia, allergic reactions, fungal infections.

Instruction on Noojerone (Method and Dosage)

Tablets should be taken orally.
Treatment and dosage regimen:
    The first week: 5 mg (in the morning).
    The second week: a daily dose of 10 mg for 2 divided doses.
    The third week: the daily dose is 15 mg, take 10 mg every morning, 5 mg in the evening.
    Fourth week: the recommended daily dose of 20 mg, which is the maximum allowable for this drug.
Instruction for the use of Noojerone has differences with respect to specific groups of patients:
    Correction of doses is not required: elderly patients (over 65) who have impaired liver function, mild and moderate hepatic impairment A, B (Child-Pugh classification).
    The initial daily dose of not more than 10 mg is possible for violations of kidney function with creatinine 5-49 ml / min.

Overdose

Among the symptoms of overdose, there was dizziness, tremors, drowsiness, agitation, convulsions, confusion, nervous excitement, aggression, stupor, hallucinations, vomiting and diarrhea.
For treatment, gastric lavage, activated charcoal and symptomatic therapy are applicable. There is no specific antidote.

Interaction

Noojerone when used concomitantly with the following drugs may cause:
    with barbiturates and neuroleptics - weakening of their effects;
    with Baclofen and Dantrolen - it is possible to change the effects, in connection with which they are correcting their doses;
    with Levodopa, dopamine receptor agonists and anticholinergic agents, their potentiation takes place;
    potentially toxic simultaneous application with Ketamine, Dextromethorphan, Phenytoin;
    with Amantadine, cimetidine, ranitidine, quinidine, quinine, nicotine as substances using the same kidney cation system for transport, there is an increase in the concentration of memantine in the blood plasma;
    with hydrochlorothiazide - a decrease in its serum concentration.

Storage conditions

The temperature of the medium should not be more than 25 ° Celsius. It is necessary to limit access to children.
Shelf life - 3 years from the production date indicated on the package.

special instructions

Alkaline reaction of urine testifies to a delay in removal of memantine and therefore requires more careful observation by medical staff. In addition, careful monitoring of MI and INR is necessary when using warfarin and other indirect anticoagulants in parallel.

Reviews of Noojerone

Reviews about the drug are few, they are left by the children and grandchildren of elderly patients suffering from dementia and memory impairments. It is noted that the tool is not cheap, but it helps a lot in critical situations, as many avoid complete helplessness and other negative manifestations of Alzheimer's disease. The doctors' comments about Noojerone are positive, they indicate its effectiveness and a small list of side effects.