Nooclerin solution 20% 100ml

Instruction for Nooclerin

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Composition

In 5 ml (one teaspoon) of deacyl aceglumate 1 g (deanol 320 mg and acetylglutamic acid 680 mg). Xylitol, methyl parahydroxybenzoate and propyl parahydroxybenzoate, water as auxiliary substances.

Form of issue

Solution for oral administration in vials of 20, 100 and 200 ml.

pharmachologic effect

Neuroprotective, nootropic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Nootropic drug, the active substance of which is close in chemical structure to the metabolites of the brain - glutamic acid and GABA. It is a neurometabolic stimulant. Has cerebroprotective, psychostimulating, anti-asthenic, antidepressant and psychharmonizing effect. Improves mood and increases activity. It facilitates the processes of assimilation and reproduction of information, improves the ability to concentrate and learn. Does not have a muscle relaxant effect, does not disrupt the coordination of movements, is not addictive. In recommended doses, hyperstimulation is not observed. Malotoxic, does not irritate the gastrointestinal mucosa.
Has hepatoprotective properties: lowers the level of transaminases and bilirubin, improves lipid and pigment metabolism, normalizes the cellular structure of the liver, reduces the severity of cirrhosis. In patients with this, weakness and drowsiness decrease, skin itching is eliminated.
The efficacy is shown in schizophrenia with asthenic and adynamic disorders, with asthenoapatic and neurosis-like disorders. When administered to children, it is effective for asthenic conditions, intellectual exhaustion, learning difficulties and difficulties. The children of older age have a timoleptic effect.
It is used in gerontological practice with functional disorders, for relief of withdrawal symptoms in alcoholism sufferers, for improving performance in athletes.

Pharmacokinetics

It is characterized by high bioavailability. After oral administration after 0.5-1 hour the maximum concentration of the active substance is found in the brain, somewhat smaller - in the liver, heart and kidneys. It is excreted by the kidneys. T1 / 2 - 24 hours.

Indications for use

As part of complex therapy is used when:
    discirculatory encephalopathy;
    asthenic and depressive disorders;
    post-stroke disorders;
    craniocerebral trauma in the period of convalescence;
    psycho-organic syndrome;
    alcohol-abstinence syndrome;
    to improve memory and attention.
Children are used for asthenic conditions, neuropsychic disorders, after traumatic brain injuries and in complex therapy of mental retardation.

Contraindications

    hypersensitivity;
    infections of the central nervous system;
    blood diseases;
    psychotic conditions;
    fever;
    age up to 10 years;
    violations of the liver, kidneys;
    pregnancy, breast-feeding.

Side effects

    sleep disorders;
    headache;
    allergic reactions;
    constipation;
    itching;
    weight loss;
    in the elderly, depression.

Nooclerin, instructions for use (Method and dosage)

In one teaspoon - 1 g of active ingredient. It is prescribed in adults for 1 -2 tsp 2-3 times a day, preferably the first half, not later than 4 hours before bedtime. A single dose is 2 g (2 tablespoons), respectively, the daily dose of 4-6 g, according to the doctor's prescription, in rare cases, 10 g per day can be taken.
The duration of the course is 2 months, with a repeat 2 times a year. Nooclerin for children from 10 years of age is prescribed in a daily dose of 0.5-1 teaspoon, and children from 12 years of age - 1-2 teaspoons.

Overdose

Overdose is manifested by increased side effects. There is a washing of the stomach, sorbents are prescribed and symptomatic treatment is carried out.

Interaction

Strengthens the action of the means that stimulate the central nervous system.

Storage conditions

Temperature up to 25 ° С.
Shelf life - 3 years.
The opened vial should not be stored for more than a month.

Reviews about Nooclerin

The advantage of this nootropic drug is that it is based on natural metabolites. This provides maximum therapeutic efficacy and a minimum of side effects. At clinical approbation it is established, that it is a little toxic and deprived of negative actions of psychostimulants. Has a pronounced nootropic and psychostimulating activity, therefore it is effective for asthenic and asthenodepressive states that arise against the background of somatic diseases, infections, reactions to acute stress. In this case, adolescents have higher efficacy than adults.
The drug is recommended for correction of neuroleptic syndrome, improvement of intellectual functions. Successfully used in sports medicine to correct the performance of athletes, as it helps to relieve fatigue, fatigue after intense stress. Important is the presence of this agent hepatoprotective properties, so it is used in the treatment of alcoholism with concomitant liver damage and liver diseases. Here are some patient testimonials.
    "... The drug is mild. If the deviations are not significant - will return to normal. But there are no strong effects from it. "
    "... The drug improves mood, when he took it - laughed heartily, of course about."
    "... There was asthenia against anemia. The hematologist prescribed, really, felt better. "
    "... The effect is, it gives an upbeat state, but it's not worth waiting for miracles."
    "... Eliminates weakness, rapid emotional and physical exhaustion. After a month of reception, it was not so diffuse and memory improved. "
    "... Assigned to postpartum asthenia (I did not breast feed). It helped well - there was activity, a desire to live and something to do. "
    "... The neuropathologist recommended for chronic fatigue after constant overload at work. Became focused, memory improved, there was a desire to live and create. "
Of the side effects, some patients reported insomnia and early awakenings.
However, there are often reviews of the external application of this drug, which is due to the fact that the preparation contains a derivative of dimethylaminoethanol (DMAE) - deanol aceglumate. Nooclerin in cosmetology is used as a source of high concentration DMAE (6.4%). It is he, but in a lesser concentration is part of creams and tonics to improve the elasticity of the skin and tighten the contour, rejuvenate the mesococtail, and also iontophoresis is performed with it. At home, many people use a drug to save money.
It is recommended to use nose-acupuncture neatly, first pointwise, to test your sensitivity, since a reaction in the form of irritations and allergies is possible. In the absence of a reaction, it can be applied in the form of a mask for 20 minutes on the face and décolleté area. It must be remembered that DMAE is not combined with retinol and acids, so you can not simultaneously apply creams with these ingredients. According to the research, DMAE moisturizes the skin, enhances metabolic processes in it, protects against free radicals. Here are some reviews on the use of this drug externally.
    "... Gives an instant lifting effect. With regular use externally does not allow to grow old, rejuvenates. "
    "... Used Nooclerin from wrinkles pointwise - where wrinkles or skin lost its tone. Visibly tightens and smoothes. "
    "... The skin is stretched. The effect persists throughout the day. "
    "... I periodically use it as a mask. The effect is pleasant - the skin is denser and fresh. "
    "... I did 2 times a week. Initially, the substance is liquid, and when it dries on the face it is sticky. "
    "... DMAE applied 1%, it was a feeling that the skin was pulled. After a while, the skin became numb and peeled off. So I will not use it any more, especially in such concentration. "
Judging by some reviews, the appearance of pigmentation is possible.