Phezam (Fezam) caps #60

Instruction for Phezam

You can buy Phezam here

Composition

The composition of capsules Phezam includes two active components - piracetam and cinnarizine.
As additional ingredients in the composition of the product are: lactose monohydrate, magnesium stearate, silicon dioxide colloid.
The capsule shell consists of gelatin and titanium dioxide.

Form of issue

The preparation of Phezam is made in the form of capsules of cylindrical shape, gelatinous, solid, size No. 0. Capsules of white color, inside - a mixture of powder, which has a white or almost white color. Within the contents inside, there can be conglomerates that turn into powder, if you press them.
Contained in blisters for 10 pcs., Blisters are put in cardboard packs.

pharmachologic effect

The abstract testifies that Phezam is a combined remedy providing nootropic, antihypoxic and vasodilating effects. Mutual potentiation of reducing the resistance of cerebral vessels is noted, improving the flow of blood in these vessels.
As Wikipedia informs, the therapeutic effect and its mechanism are determined by the main active substances that are part of the preparation of Phezam. The main effect that is noted after taking the drug is an improvement in blood circulation in the brain and metabolic processes in the nerve fibers and brain cells.
The substance of piracetam has a nootropic effect, activating the activity of the brain, positively affecting the metabolism in the body. Under the action of the substance, the rate of consumption of glucose, which is the main nutrient for the brain, increases. Thus, under the influence of pyracetam, more active nutrition of the cells takes place, which leads to the development of more energy and activation of the function of the brain. Pyracetam promotes an increase in the rate of transfer of impulses between neurons. As a consequence, memory is increased, concentration of attention is improved, which leads to an increase in intellectual function.
Also, piracetam improves blood flow in those parts of the brain where there are damaged vessels, and also ischemia, that is, oxygen starvation. As microcirculation improves, the ischemic zones that result from lack of oxygen disappear, and the entire volume of neurons participate in the brain.
In addition, there is an indirect effect of this component, contributing to the activation of blood flow. It is provided due to inhibition of the process of gluing together platelets, which is essentially a prophylaxis for the appearance of thrombi. That is, the component of piracetam not only activates blood flow, but also improves its properties. Thus, the blood circulates more actively through microvessels.
Under the influence of pyracetam, the resistance of neurons to hypoxia increases. Piracetam improves the integrative function of the brain, activates intellectual work, facilitates the learning process of new material, provides recovery and support of brain functions in people in old age.

The substance cinnarizine is expressed directly affects the vessels of the brain, expanding them. Also, under the influence of this substance, the tone of smooth muscles decreases, their reaction to active substances that narrows the vessels decreases. Due to the fact that the substance dilates the blood vessels, the blood flow is activated, and more oxygen and nutrients enter the brain. In view of the improvement in blood flow, the stability of brain tissues to oxygen deficiency also increases. In this case, despite the vasodilator effect, cinnarizine does not affect the indices of arterial and intracranial pressure.
The presence of these two components in the composition of Phezam provides mutual reinforcement of the effects of the active components. Consequently, the severity of the effect of the drug is more pronounced compared with the reception of these components separately.
When taking Phezam, there is a predominance of sedative action of cinnarizine, from which the drug does not lead to the appearance of psychomotor agitation, as occurs when taking piracetam.

Pharmacokinetics and pharmacodynamics

After the patient took Phezam tablets inside, the active substances are completely absorbed from the gastrointestinal tract.
The highest concentration of pyracetam in plasma is observed after 2-6 hours, cinnarizine after 1-4 hours. The bioavailability level of piracetam is 100%.
With plasma proteins, pyracetam is not bound, cinnarizine binds to 91%. It penetrates through the BBB, it is determined in all tissues and organs, passes through the placental barrier. His selective accumulation in the cerebral cortex is noted.
The substance of pyracetam is not metabolized, the metabolism of cinnarizine occurs in the liver.
The half-life of piracetam is 4-5 hours (from the blood), 8.5 hours (from the cerebrospinal fluid). It is mainly excreted through the kidneys.
The half-life of cinnarizine is 4 hours. Metabolites are excreted mostly in urine, as well as with faeces.
In people with kidney failure, the half-life of piracetam increases.

Indications for use of Phezam

Before using the drug Phezam, indications for use should be taken into account. The drug is prescribed in such cases:
    with insufficiency of blood flow in the brain (in the case of arteriosclerosis of the vessels, during the recovery from ischemic or hemorrhagic strokes, with encephalopathy of different origin, after the CCT);
    in case of intoxication;
    in diseases of the central nervous system, in which there is a decrease in intellectual-mnestic functions, that is, deterioration of attention, memory, mood;
    with psychoorganic syndrome, in which the signs of asthenia and adynamia predominate;
    consequences of traumatic brain injury;
    Labyrinthopathy (sensation of noise in the ears, dizziness, nausea and vomiting);
    asthenic syndrome associated with psychogenic origin;
    Meniere's syndrome;
    with the purpose of prevention of migraine, kinetosis;
    in the complex therapy of children who have a psycho-organic syndrome, which led to low learning ability.

Contraindications

Medication Phezam should not be taken in the following cases:
    with severe forms of renal and hepatic insufficiency;
    in the period of increased psychomotor agitation;
    with Huntington's chorea;
    during pregnancy and breastfeeding;
    at the age of the patient up to 5 years;
    at a high sensitivity to the components of the agent.
The drug is prescribed with caution to those patients who have Parkinson's disease, hemostasis disorders, liver or kidney function disorders, severe bleeding.

Side effects of Phezam

The following side effects are possible during treatment:
    nervous system: nervousness, sensation of drowsiness, hyperkinesia; in rare cases - headaches, dizziness, insomnia, ataxia, agitation, anxiety;
    allergic manifestations: in rare cases - a rash on the skin, dermatitis, edema, itching, photosensitivity.
    system of digestion: strong salivation, nausea, vomiting, abdominal pain, diarrhea;
    other manifestations: increased libido.

Phezam capsules, instructions for use (Method and dosage)

The instruction on the use of Phezam, which is provided in the annotation to the drug, indicates that the medicine should be taken 1-2 capsules three times a day for one to three months. The duration of treatment depends on the severity of the disease. The drug, as a rule, take courses - 2-3 courses per year.
Children after 5 years are shown taking 1-2 capsules 1-2 times a day. Capsules are applied for from one and a half to three months. Take capsules need to swallow them whole, without violating the integrity of the capsule. Take the tablet with half a glass of water, and it should not be hot.
Many users ask about capsules how to take - before or after a meal. In the instruction it is a question of that the special difference in that, before meal or after meal to accept means, is not present. But it is optimal to drink capsules 20-30 minutes after eating. It is advisable to drink the medicine every day at the same time.
Doctors warn that it is impossible to take medicine for longer than 3 months - there is a break between the courses.

Overdose

As a rule, Phezam medication is well tolerated by patients and when receiving large doses of the drug there are no significant side effects that require discontinuation of treatment. Patients with an overdose may have abdominal pain. When taking too large doses of the medicine, it is necessary to rinse the stomach, induce vomiting. If there is such a need - to conduct hemodialysis and symptomatic treatment. There is no specific antidote.

Interaction

Not with all drugs at the same time you can take Phezam tablets, which should take into account the interaction of this drug with other drugs.
When taking medications simultaneously with Phezam, which inhibit the CNS, ethanol, tricyclic antidepressants, their sedative effect may increase.
When taking the drug Phezam potentiates the influence of nootropic and antihypertensive drugs.
Vasodilator drugs enhance the effect of Phezam.
Due to the presence of cinnarizine in the drug, the activity of hypertensive drugs decreases.
With the simultaneous administration of Phezam, there is an increase in the activity of thyroid hormones, which can lead to tremors and anxiety.
In view of antihistamine action, cinnarizine can mask the manifestation of positive reactions in relation to skin reactivity factors during skin tests. To avoid this effect, it is necessary to stop using the medication 4 days before such tests.
Phezam can enhance the effect of oral anticoagulants.

Storage conditions

It is necessary to store the medicine at a temperature of up to 25 ° C, in a dark place. Keep away from children.
Shelf life of capsules is 3 years.

special instructions

If Phezam is prescribed to patients who have liver function abnormalities, hepatic enzymes should be monitored.
The drug activates the functions of the thyroid hormones, which can cause anxiety and tremors in patients undergoing treatment.
Since cinnarizine can provoke signs of drowsiness, during the period of treatment it is necessary to drive cautiously and to work with precise and dangerous mechanisms.
When treating people in old age, you need to regularly monitor the indicators of kidney function and, if necessary, adjust the dose.
Active components are able to penetrate the filter membranes of hemodialysis machines.
It is necessary to avoid taking medication in case of porphyria.
When taking Phezam, a false positive result may appear in doping control in athletes, and, in connection with the presence of iodine-containing dyes in the capsule shell, a false positive result can be noted in the test for the determination of radioactive iodine.
Since piracetam reduces platelet aggregation, it is necessary to prescribe it cautiously when hemostasis is impaired in patients, as well as in conditions accompanied by hemorrhages. Do not take the medicine for complicated surgical operations, with severe bleeding and hemorrhagic stroke in the anamnesis.
Phezam can provoke irritation in the epigastric region, when applied after meals, there may be a decrease in the severity of gastric irritation, which should be carefully applied to patients suffering from gastrointestinal diseases.
It should be noted that the composition of the product as an auxiliary component contains lactose.

Compatibility with alcohol

Alcohol and Phezam can not be used at the same time, according to the instructions to the drug. With their simultaneous admission, the risk of stroke increases, and a negative effect on the liver is noted. Therefore, during the treatment period, you must completely give up alcohol.

Children

Children under 5 years of these capsules are not prescribed. Children after 5 years should be given a medicine strictly according to the scheme prescribed by the doctor. The comments of doctors and parents testify that with the help of this medicine in school-age children it is possible to normalize sleep, improve working capacity, and remove irritability.

In pregnancy and lactation

Contraindicated the use of Phezam during pregnancy, although there is no information on the negative effect of active components. Piracetam enters breast milk, so do not use the product during lactation.

Reviews about Phezam

Most often reviews about Phezam on the forums are positive, they are talking about improving the condition of patients when taking this medication. Users write that after reception the memory is normalized, attention and efficiency improves. Also under the influence of medicine, stress, anxiety is reduced.
Similar positive responses appear when using capsules to children.
At forums where the preparation of Phezam is discussed, doctors' reviews are also more often positive. However, there are also negative comments that the drug causes drowsiness, as well as the lack of positive action in the treatment.