Omaron tabs #90

Omaron instruction

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Composition

1 Omaron tablet contains 400 mg of piracetam and 25 mg of cinnarizine - the active components.
Auxiliary Ingredients:
    0.0235 g of lactose monohydrate;
    0.0468 g of magnesium pentahydrate hydroxy carbonate;
    0.0039 g of povidone K30;
    0,0052 - aerosil А-380;
    0.0052 g of calcium stearate monohydrate;
    0.0104 g of crospovidone.

Form of issue

Tablets are flat-cylindrical forms of 30, 60 or 90 pieces in one package.

pharmachologic effect

Nootropic, antihypoxic, vasodilating.

Pharmacodynamics and pharmacokinetics

Omaron is a combined drug that has antihypoxic, vasodilating and nootropic effects.
Pyracetam, one of Omaron's active substances, enhances energy and protein metabolism, accelerates the utilization of glucose by cells and increases their resistance to hypoxia, thereby activating the metabolic processes in the brain. In the central nervous system positively affects the inter-neuronal transmission, in the ischemic zone improves the system of regional blood flow.
The second active ingredient, cinnarizine, is a selective blocker of slow calcium channels, inhibits the influx of calcium ions into cells, reduces their concentration in the depot of the plasmolemma, weakens the tone of the smooth muscles of the arterioles, suppresses their response to biogenic sosudosugging agents (norepinephrine, epinephrine, dopamine, vasopressin, angiotensin) .
Exhibits vasodilatory action (especially with respect to vessels of the brain), increases the efficiency antihypoxic piracetam, while not substantially affecting the blood pressure. Has a moderate antihistaminic activity, reduces the excitability of the vestibular apparatus, it leads to a decrease in sympathetic nervous system tone, as well as beneficial effects on the elasticity of the erythrocyte membranes, their susceptibility to deformation improves blood viscosity.
After oral administration of piracetam completely and fairly rapidly absorbed from the digestive tract, reaching Cmax in plasma over 6.2 hours, and for 2-8 hours in the cerebrospinal fluid, has a 100% bioavailability.
The medicine does not bind to plasma proteins, it spreads practically across all tissues and organs of the body, passes the placental barrier. In the cerebral cortex selectively accumulates mainly in the occipital, parietal, and frontal lobes, basal ganglia and cerebellum.
Piracetam does not give in to metabolism and after about 30 hours is excreted in the urine (more than 95%).
Cinnarizine in blood plasma reaches Cmax in 1-4 hours. With plasma proteins binds to 91%.
The metabolism of cinnarizine is active and complete, with a half-life that is 4 hours.
A third of the metabolites are excreted by the kidneys, the rest is the intestine.

Indications for the use of Omaron

Indications for the use of Omaron are diseases of the central nervous system, which are accompanied by intellectual and mnestic disorders:
    treatment of posttraumatic or post-toxication encephalopathy;
    cerebral insufficiency circulatory therapy (including its vessels in atherosclerosis, as well as the recovery period after suffering hemorrhagic and ischemic stroke);
    depression;
    retardation of mental development in childhood;
    disorders of the vestibular apparatus;
    psychoorganic syndrome, mainly with signs of adynamia and asthenia;
    Meniere's syndrome;
    with the goal of preventing migraine attacks, as well as kinetosis, in adults and children.

Contraindications

    Individual hypersensitivity to pyracetam, cinnarizine or other ingredients of Omaron;
    lactase deficiency, lactose intolerance, glucose-galactose malabsorption syndrome (due to the content of lactose in the composition of the drug);
    severe liver diseases, as well as kidneys (with creatinine clearance (CC) less than 20 ml / min);
    Parkinsonism;
    hemorrhagic stroke;
    Huntington's syndrome;
    psychomotor agitation;
    lactation period and gestation period;
    age up to 5 years.

Carefully:

    CRF (KK - 20-80 ml / min);
    pathology of the liver and / or kidneys (medium and light weight);
    porphyria;
    increased intraocular pressure;
    violation of hemostasis;
    heavy bleeding;
    surgical interventions on large areas of the body;
    epilepsy;
    hyperthyroidism;
    predisposition to neurotic reactions;
    atherosclerosis of cerebral vessels.

Side effects

Peripheral and central nervous system:

    irritability;
    motor disinhibition;
    drowsiness;
    asthenia;
    depression;
    headache.

In rare cases:

    dizziness;
    exacerbation of epilepsy;
    ataxia;
    extrapyramidal disorders;
    imbalance;
    tremor;
    decreased concentration of attention;
    excitation;
    increased sexuality;
    insomnia;
    anxiety;
    hallucinations.

The cardiovascular system:

    increase or decrease in blood pressure.

Digestive system:

    feeling of dryness in the mouth;
    dyspeptic phenomena.

In rare cases:

    nausea;
    diarrhea;
    stomach ache;
    vomiting;
    cholestatic jaundice.

Skin covers (in rare cases):

    itching;
    dermatitis;
    rash on the skin.

Allergic manifestations:

    angioedema.

Others:

    increased sweating;
    increase in body weight.

In rare cases:

    red flat lichen;
    lupus-like syndrome.

Omaron tablets, instructions for use

Instructions for use Omaron recommends the taking of tablets orally (inside) during the reception seek or immediately after a meal.
Adult patients are usually prescribed 1-2 Omaron tablets three times a day, for 30-90 days, depending on the pathology and its severity. Therapy courses can be carried out 2-3 times a year.
Children after reaching 5 years of age are recommended 1 or 2 doses per day for 1-2 tablets. The maximum allowable time for the therapy is 3 months.
In order to prevent kinetosis, adult patients take 1 tablet, children after 5 years - half of the pill. Reception of Omaron is carried out 30 minutes before the proposed journey and can be repeated in 6-8 hours.
With CRF (KK - 20-80 ml / min), one tablet can be used 2 times a day.

Overdose

When Omaron overdoses, vomiting, impaired consciousness, lowering blood pressure, extrapyramidal symptoms may occur. When taking a dose of Piracetam 75 g or more, there were abdominal pains and diarrhea with blood.
Since there is no specific antidote, gastric lavage is performed and enterosorbents are prescribed. In the future, if necessary, supportive and symptomatic therapy is recommended.
The efficiency of hemodialysis is 50-60% (in relation to pyracetam).

Interaction

When combined with ethanol, drugs, oppressive central nervous system, antihypertensive and nootropic drugs, there is an increase in their sedative effect.
Vasodilating drugs enhance the effect of Omaron.
Omaron improves the tolerability of tricyclic antidepressants, as well as antipsychotics.
Pyracetam can strengthen the central effects of drugs based on thyroid hormones (sleep disorders, tremors, irritability, anxiety).
When taken concomitantly with oral anticoagulants, Omaron may increase their effect.

Storage conditions

At a temperature of no higher than 25 ° C.
Shelf life - 36 months.

special instructions

With prolonged admission Omaron recommended to monitor the liver and kidneys (especially in patients with CHF).
During the therapy in patients with arterial hypotension, a more pronounced decrease in blood pressure was observed.
There may be a mistake in the results of skin allergic tests and a doping test, in this connection, 4 days before the proposed study, Omaron should be canceled.

Omaron or Phezam, which is better?

According to experts who use Omaron and Phezam in their practice, these medications are almost identical and are used for the same diseases, have the same side effects, indications and contraindications, and also have equal effectiveness.
All this is due to the fact that these drugs in their composition have the same set of active substances (piracetam and cinnarizine), that is, in fact, are synonymous. It is worth noting that the price of Phezam is somewhat larger, compared with the price of Omaron.

Children

The drug Omaron is contraindicated in patients under 5 years of age.

With alcohol

In the process of treatment, Omaron is recommended not to drink alcohol.

During pregnancy (and lactation)

Omaron is not used during lactemia and pregnancy.

Reviews about Omaron

For the treatment of certain diseases of the central nervous system, which are accompanied by intellectual-mnestic disorders, combined nootropic drugs are widely used, among which one of the significant places is taken by the drug Omaron. The doctors' comments on this medicine are overwhelmingly positive. Specialists note the high efficiency of Omaron both during the treatment and when it is prescribed for the purpose of preventing such painful conditions as migraine and motion sickness syndrome.
It must be remembered that the choice of a nootropic drug requires a personal approach to each patient, so even if you do not fit Omaron, an experienced doctor will select his analog without any problems.