Cavinton Forte 10mg #30
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Cavinton Forte user manualReed more and buy Cavinton Forte on this pageComposition1 tablet contains 10 m vinpocetine - an active drug.Additional ingredients: talc, magnesium stearate, colloidal silicon dioxide, lactose monohydrate..
Cavinton Forte user manual
Reed more and buy Cavinton Forte on this page
1 tablet contains 10 m vinpocetine - an active drug.
Additional ingredients: talc, magnesium stearate, colloidal silicon dioxide, lactose monohydrate, corn starch.
Form of issue
The company Gedeon Richter produces Cavinton Forte in the form of tablets of 30 or 90 pieces per pack.
Improving blood circulation of the brain, vasodilating, neuroprotective, antihypoxic, antiaggregational.
Pharmacodynamics and pharmacokinetics
Cavinton Forte is a medicinal product whose action is aimed at improving cerebral metabolism, as well as increasing the consumption of brain tissues by oxygen and glucose. Vinpocetine increases the resistance of hypoxia neurons, increases the delivery of glucose to brain tissues through the BBB, converts glycolysis to a more energy-efficient process of aerobic glucose breakdown, selectively blocks calcium-dependent PDE. Increases in the brain concentrations of cGMP and AMP, the content of ATP and the relative ratio of ATP / AMP, increases tissue metabolism of serotonin and norepinephrine, activates the cell formation of the ascending noradrenergic system, and has antioxidant efficacy. Reduces the ability of platelets to aggregate and dilutes blood, enhances the deforming properties of red blood cells and prevents their utilization of adenosine, helps to increase the return of erythrocytes of oxygen. Expands the neuroprotective effects of adenosine. Increases cerebral blood flow and reduces cerebral vascular resistance, while not significantly affecting the systemic circulation (including blood pressure, heart rate, minute volume, total peripheral resistance). It is not characterized by the effect of stealing, and even increases blood supply, especially in ischemic areas of the brain with insufficient perfusion.
When administered orally, vinpocetine is absorbed most of the time in the proximal parts of the gastrointestinal tract. The average Tmax equals 60 minutes. Does not lend itself to metabolic changes when passing through the walls of the intestine. Tissue Cmax is observed after 2-4 hours. The connection with plasma proteins is 66%, bioavailability is about 7%. Metabolized outside the liver, as evidenced by its clearance - 66.7 l / h, exceeding the hepatic plasma volume (50 l / h). At further oral application in a range of doses of 5-10 mg linear kinetics of a preparation is traced. It is excreted by the intestines and kidneys in a ratio of 2: 3. T1 / 2 fluctuates within 4-6 hours.
Indications for use Cavinton Forte
Indications for use of the drug include the states of cerebral circulatory insufficiency, where Cavinton Forte is used to reduce the symptoms of mental and neurological disorders. These conditions include: the rehabilitation period after ischemic stroke, the recovery stage after hemorrhagic stroke, post-stroke complications, cerebral arteriosclerosis, vascular dementia, transient ischemic attack, vertebrobasilar insufficiency, hypertensive / post-traumatic encephalopathy.
In otorhinolaryngology, the use of drugs for the treatment of idiopathic ear noise, Meniere's disease and conditions that occur with perceptual hearing loss is shown.
Also, the drug is used for chronic vascular pathologies of the eyes, including damage to the retina of the eyes and their choroid.
IHD in severe form;
hemorrhagic stroke in acute phase;
age up to 18 years;
The cardiovascular system:
sensation of tides;
changes on ECG (prolongation of QT-interval, ST depression);
lability of blood pressure;
dryness in the oral cavity;
belching / heartburn;
a feeling of nausea.
Cavinton Forte, instructions for use
Instructions for use Cavinton Forte recommends the internal (oral) taking of the drug tablets, after meals.
Duration of treatment and sufficient dosage of the drug is prescribed by the physician based on the individual situation.
As a rule, tablets are taken three times in 24 hours in a dose of 5-10 mg. To begin therapy it is necessary from a daily dose in 15 mg, with its or her increase, if necessary, up to the maximum admissible daily dose in 30 mg. The therapeutic effectiveness of treatment is observed after 7 days, and the full effect of therapy requires taking the drug for 3 months.
Liver / kidney pathologies do not require correction of the dosage regimen.
At this time, information on overdose is not fully presented, however, in case of reasonable suspicion of taking overestimated doses of the drug and dependent on the occurrence of undesirable phenomena, standard methods / therapies used in such circumstances (induction of vomiting, gastrointestinal purulence, sorbents intake and t .).
The combined use of methyldopa sometimes led to a certain increase in the hypotensive effect, which is why, in this combination, it is necessary to constantly monitor blood pressure.
With parallel application with Imipramine, Klopamid, Pindolol, Glibenclamide, Asenocoumarol, Digoxin and Hydrochlorothiazide, no significant interactions were observed.
Judging by the effects of vinpocetine, its co-administration with antiarrhythmic drugs, central and anticoagulant actions should be carried out with caution, although to date there is no data on such interactions.
Limitation of the temperature of the storage of tablets is 15-30 ° C.
Since production - 5 years.
If the patient is diagnosed with lactose intolerance, attention should be paid to the content of 83 mg of lactose monohydrate in 1 tablet.
When patients are treated with a prolonged QT-interval syndrome or parallel drug intake, leading to prolongation of the QT-interval, ECG monitoring should be performed periodically.
Analogues Cavinton Forte
The lack of experience of appointments Cavinton Forte under the age of 18 determines this age category of patients in contraindications to its use.
Throughout therapy, it is best not to drink beverages that include alcohol.
In pregnancy and lactation
Vinpocetine is not prescribed to pregnant women, because penetrating the placental barrier, especially in high doses, it can cause placental bleeding, and in some cases spontaneous abortions, most likely due to an increase in placental blood supply.
A 0.25% dose of vinpocetine for 60 minutes falls into the milk of a nursing mother, and therefore its use is prohibited during this period.
Reviews of Cavinton Forte
By and large reviews about Cavinton Fort are positive. Many patients with different indications, undergoing a full course of therapy with this drug, felt a significant improvement in their morbid condition and observed increased mental and physical abilities, the disappearance of headaches and dizziness, improved memory, sleep, general well-being, and much more.
For some patients (about 20%), this drug did not fit or caused a number of rather tangible side effects that overlapped the therapeutic effect. It is rare to find feedback on the intensification of those negative symptoms, for which the drug was actually created, although these phenomena can be caused by the progression of the underlying disease.