Arbidol Maximum caps 200mg #10

Arbidol Maximum instruction for use

You can buy Arbidol Maximum here

The composition of one capsule

Active ingredient: umifenovir hydrochloride monohydrate (in terms of umifenovir hydrochloride) - 200 mg.
Excipients: potato starch - 52.67 mg, microcrystalline cellulose - 11.20 mg, colloidal silicon dioxide (aerosil) - 2.80 mg, povidone (kollidon 25) - 7.73 mg, calcium stearate - 2.80 mg, Croscarmellose sodium - 2.80 mg, the mass of the capsule contents - 280 mg.
Solid gelatin capsules No. 0:
The composition of the capsule shell (body and cap): titanium dioxide (E 171) - 1.92 mg, gelatin - 94.08 mg. The total weight of the capsule is 376 mg.

Description

Solid gelatin capsules No. 0 white. The contents of the capsule - a mixture containing granules and powder of white or white with a greenish yellow or cream color to light yellow or light yellow with a greenish color.
Pharmacotherapeutic group: antiviral agent.
ATX code: J05AX13

Pharmacodynamics

Antiviral agent. It specifically inhibits in vitro influenza A and B viruses (Influenzavirus A, B), including highly pathogenic A (H1N1) pdm09 and A (H5N1) subtypes, as well as other viruses that cause acute respiratory viral infections (ARVI) (coronavirus (Coronavirus), associated with severe acute respiratory syndrome (SARS), rhinovirus (Rhinovirus), adenovirus (Adenovirus), respiratory syncytial virus (Pneumovirus) and parainfluenza virus (Paramyxovirus)). The mechanism of antiviral action refers to fusion inhibitors (fusions), interacts with the hemagglutinin of the virus and prevents the fusion of the lipid envelope of the virus and cell membranes. It has a moderate immunomodulatory effect, increases the body's resistance to viral infections. It has interferon-inducing activity - in a study on mice, the induction of interferons was observed already after 16 hours, and high titers of interferons remained in the blood for up to 48 hours after administration. Stimulates cellular and humoral immunity reactions: increases the number of lymphocytes in the blood, especially T-cells (CD3), increases the number of T-helper cells (CD4), without affecting the level of T-suppressors (CD8), normalizes the immunoregulatory index, stimulates the phagocytic function of macrophages and increases the number of natural killer cells (NK cells).
Therapeutic efficacy in viral infections manifests itself in reducing the duration and severity of the disease and its main symptoms, as well as reducing the incidence of complications associated with viral infection and exacerbations of chronic bacterial diseases.
In the treatment of influenza or acute respiratory viral infections in adult patients, a clinical study showed that the effect of the drug in adult patients is most pronounced in the acute period of the disease and is manifested by a reduction in the resolution of symptoms of the disease, a decrease in the severity of the disease, and a reduction in the elimination of the virus.
Drug therapy leads to a higher frequency of stopping the symptoms of the disease on the third day of therapy compared to placebo - 60 hours after the start of therapy, the resolution of all symptoms of laboratory-confirmed influenza is more than 5 times higher than in the placebo group.
A significant effect of the drug on the rate of elimination of the influenza virus was established, which, in particular, was manifested by a decrease in the frequency of virus RNA detection on the 4th day.
Treats low-toxic drugs (LD50> 4 g / kg). Does not have any negative effects on the human body when administered orally at recommended doses.

Pharmacokinetics

Rapidly absorbed and distributed to organs and tissues. The maximum concentration in the blood plasma when taken at a dose of 50 mg is reached after 1.2 hours, at a dose of 100 mg - after 1.5 hours. Metabolized in the liver. The average half-life is 17-21 hours on average. About 40% is excreted unchanged, mainly with bile (38.9%) and in small amounts by the kidneys (0.12%). During the first day, 90% of the injected dose is eliminated.

Indications for use

Prevention and treatment in adults and children 12 years of age: influenza A and B, other acute respiratory viral infections.
Combined therapy of recurrent herpes infection.
Prevention of postoperative infectious complications.
Combined therapy of acute intestinal infections of rotavirus etiology in children over 12 years old.

Contraindications for Arbidol Maximum

Hypersensitivity to umifenovir or any component of the drug; children's age up to 12 years. First trimester of pregnancy. Breastfeeding period.

Carefully

The second and third trimesters of pregnancy.

Use during pregnancy and during breastfeeding

In animal studies, no adverse effects on pregnancy, embryo and fetus development, generic activity, or postnatal development were identified.
Use of the drug Arbidol Maximum in the first trimester of pregnancy is contraindicated.
In the second and third trimester of pregnancy, Arbidol Maximum can only be used for the treatment and prevention of influenza and if the intended benefit to the mother outweighs the potential risk to the fetus. The ratio of benefit / risk is determined by the attending physician.
It is not known whether Arbidol Maximum penetrates breast milk in women during lactation. If necessary, use Arbidol Maximum should stop breastfeeding.

Dosage and administration

Inside, before meals.
A single dose for adults and children over 12 years old - 200 mg (1 capsule).
 The drug is started from the moment the first symptoms of the flu and other acute respiratory viral infections appear, preferably not later than 3 days from the onset of the disease.
If after using Arbidol for a maximum of three days in the treatment of influenza and other acute respiratory viral infections, severity of symptoms of the disease persists, including a high temperature (38 ° C or more), then you should consult a doctor to assess the feasibility of taking the drug.
Use the drug only in accordance with the indications, the method of application and in the doses indicated in the instructions.
In the treatment of influenza and ARVI, concomitant symptomatic therapy is possible, including the administration of antipyretic drugs, mucolytic and local vasoconstrictor drugs.

Side effect

The drug Arbidol Maximum belongs to low-toxic drugs and is usually well tolerated.
Side effects are rare, usually mild or moderate, and are transient in nature.
The frequency of undesirable drug reactions is determined in accordance with the WHO classification: very often (with a frequency of more than 1/10), often (with a frequency of at least 1/100, but less than 1/10), infrequently (with a frequency of at least 1/1000, but less than 1/100), rarely (with a frequency of at least 1/10000, but less than 1/1000), very rarely (with a frequency of less than 1/10000), the frequency is unknown (cannot be established from the available data).
Immune system disorders: rarely allergic reactions.
If any of the side effects indicated in the instruction are aggravated, or you have noticed any other side effects that are not indicated in the instruction, inform your doctor.

Overdose

Unchecked.

Interaction with other drugs

When prescribing with other drugs, no negative effects were noted.
Special clinical studies on the interactions of Arbidol Maximum with other drugs have not been conducted.
Information about the presence of undesirable interactions with antipyretic, mucolytic and local vasoconstrictor drugs in a clinical study have not been identified.

special instructions

It is necessary to comply with the recommended in the instructions scheme and the duration of the drug. In the case of missing a single dose of the drug, the missed dose should be taken as early as possible and continue the course of taking the drug according to the schedule.
If after using Arbidol for a maximum of three days in the treatment of influenza and other acute respiratory viral infections, severity of symptoms of the disease persists, including a high temperature (38 ° C or more), then you should consult a doctor to assess the feasibility of taking the drug.

Influence on ability to drive vehicles and mechanisms

It does not show central neurotropic activity and can be used in medical practice in persons of various professions, incl. requiring increased attention and coordination of movements (drivers of transport, operators, etc.).

Release form

200 mg capsules.
On 10 capsules in a blister strip packaging from a film of polyvinyl chloride and aluminum foil printed lacquered.
1 or 2 blister packs with instructions for use are placed in a pack of cardboard.

Storage conditions

Store at a temperature not higher than 25 ° C. Keep out of the reach of children.
Shelf life - 2 years. Do not use after the expiration date printed on the package.

Terms of sell

You can buy Arbidol Maximum without a prescription.