Arbidol powder 25mg/5ml 37gr

Arbidol powder instruction

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See also - Arbidol capsules

5 ml formulation

active substance: umifenovir (ufifenovir hydrochloride monohydrate - 25.88 mg), (in terms of umifenovir hydrochloride - 25.00 mg);
auxiliary substances: sodium chloride - 26,85 mg, maltodextrin (Kleptose Linekaps) 750,00 mg, sucrose (sugar) 840.42 mg, silicon dioxide colloid (aerosil) 24,60 mg, titanium dioxide 25,00 mg, pregelatinized starch (type PA5PH) - 129,50 mg, sodium benzoate - 9,25 mg, banana flavor - 12,40 mg, cherry flavoring - 6,10 mg.
Description: granular powder white or almost white with a characteristic fruity odor.
Description of the prepared suspension: a homogeneous suspension of white or almost white with a yellowish or creamy hue of color with a characteristic fruity odor.
Pharmacotherapeutic group: antiviral.
ATC code: [J05AX]

Pharmacological properties

Pharmacodynamics

An antiviral agent. Specifically suppresses influenza A and B viruses (Influenzavirus A, B) in vitro, including the highly pathogenic subtypes A (H1N1) pdm09 and A (H5N1), as well as other viruses that cause acute respiratory viral infection (coronavirus) associated with severe acute respiratory syndrome SARS), rhinovirus (Rhinovirus), adenovirus (Adenovirus), respiratory syncytial virus (Pneumovirus) and parainfluenza virus (Paramyxovirus)). By the mechanism of antiviral action refers to the inhibitors of fusion (fusion), interacts with the hemagglutinin of the virus and prevents the fusion of the lipid envelope of the virus and cell membranes. Has interferon-inducing activity - in a study in mice, induction of interferons was observed already after 16 hours, and high titers of interferons remained in the blood up to 48 hours after administration. Stimulates cellular and humoral immune responses: increases the number of lymphocytes in the blood, especially T cells (CD3), increases the number of T-helpers (CD4), without affecting the level of T-suppressors (CD8), normalizes the immunoregulatory index, stimulates the phagocytic function of macrophages and increases the number of natural killers (NK cells).
Therapeutic efficacy in viral infections is manifested in a reduction in the duration and severity of the course of the disease and its underlying symptoms, as well as in reducing the incidence of complications associated with a viral infection and exacerbations of chronic bacterial diseases.
Refers to low-toxic drugs (LD50> 4 g / kg). Does not have any negative effects on the human body when administered orally at recommended doses.
Pharmacokinetics. Quickly absorbed and distributed to organs and tissues. The maximum concentration in blood plasma when taking the drug at a dose of 200 mg of Umifenovir is reached after 1 hour, the volume of distribution (Vd) is 1432 liters. Metabolised in the liver. The half-life on the average is 11 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and, in a small amount, kidney (0.12%). During the first day, 90% of the administered dose is withdrawn.

Indications for use

- prevention and treatment of influenza A and B, other ARVI in children from 2 years and adults;
- complex therapy of acute intestinal infections of rotavirus etiology in children from 2 years;
- Nonspecific prevention of severe acute respiratory syndrome (SARS) in children from 6 years of age and adults;
- Treatment of severe acute respiratory syndrome (SARS) in children older than 12 years and adults.

Contraindications for Arbidol powder

Hypersensitivity to umifenovir or any component of the drug.
Age to 2 years; age to 6 years (according to indications nonspecific prophylaxis of SARS); age up to 12 years (according to the indication of SARS treatment).
Deficiency of sugar / isomaltase, intolerance to fructose, glucose-galactose malabsorption.
Application in pregnancy and during breastfeeding
The use of Arbidol powder during pregnancy is contraindicated. It is not known whether the active substance of Arbidol or its metabolites penetrates into breast milk in women during lactation. If the use of the drug Arbidol should stop breastfeeding.

Dosing and Administration

Inside, before eating.

Preparation of the suspension.

In a vial containing a powder, add 30 ml (or approximately 2/3 of the volume of the vial) of boiled and cooled to room temperature water. The vial is closed with a lid, turned over and shaken carefully until a uniform suspension is obtained. Add boiled and cooled water to a volume of 100 ml (until the label on the vial) and shake again. Before each intake, the contents of the vial should be shaken carefully until a uniform suspension is obtained. Single dose metered using the attached measuring spoon.

Single dose (depending on age):

Age
from 2 to 6 years 10 ml (50 mg)
from 6 to 12 years 20 ml (100 mg)
over 12 years and adults 40 ml (200 mg)
Indication
In children from 2 years of age and adults:
Nonspecific prophylaxis during the epidemic of influenza and other acute respiratory viral infections in a single dose 2 times a week for 3 weeks.
Nonspecific prevention in direct contact with patients with influenza and other SARS in a single dose once a day for 10-14 days.
Treatment of influenza and other acute respiratory viral infections in uncomplicated course in a single dose 4 times a day (every 6 hours) for 5 days.
In children from 2 years:
Complex therapy of acute intestinal infections of rotavirus etiology in a single dose 4 times a day (every 6 hours) for 5 days.
For non-specific prophylaxis and treatment of severe acute respiratory syndrome (SARS):
For nonspecific prevention of SARS (in contact with the patient) in children from 6 years of age and adults:
children from 6 to 12 years old - 20 ml (100 mg), children over 12 years and adults - 40 ml (200 mg) once a day for 12-14 days.
For the treatment of SARS in children from 12 years of age and adults:
children over 12 years and adults - 40 ml (200 mg) 2 times a day for 8-10 days.

Side effects of Arbidol powder

Allergic reactions: rarely (with a frequency of not less than 1/10000, but less than 1/1000) - skin itching, rash, angioedema, hives; very rarely (with a frequency of less than 1 / 10,000) - anaphylactic reactions.
If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Not checked.

Interaction Arbidol powder with other medicinal products

In the appointment with other drugs, no negative effects were noted.

special instructions for Arbidol powder

When appointing patients with diabetes, as well as with a low-calorie diet, it must be taken into account that sucrose is included in the suspension (0.8 g / 5 ml or 0.06 XE / 5 ml).
It is necessary to follow the recommended in the instructions scheme and the duration of the drug. If you miss one dose of the drug - the missed dose should be taken as soon as possible and continue the course of taking the drug according to the scheme started.
When calculating the amount of suspension necessary for the course of administration, it is necessary to take into account the shelf life of the prepared suspension, which is 10 days. On the course of admission on the basis of indications nonspecific prophylaxis during the epidemic of influenza and other acute respiratory viral infections in children from 2 to 6 years will require two bottles of Arbidol.
Impact on the ability to drive vehicles and mechanisms
It does not show central neurotropic activity and can be used in medical practice in persons of various professions, including requiring increased attention and coordination of movements (drivers of transport, operators, etc.).

Form of issue

Powder for suspension for oral administration, 25 mg / 5 ml.
For 37 g in bottles with a capacity of 125 ml (labeled to a level of 100 ml) of dark (amber) glass.
One bottle together with the instruction for use and a measuring spoon is placed in a pack of cardboard.

Storage conditions

Store at a temperature not exceeding 25 ° C.
The prepared suspension should be stored at a temperature not exceeding 8 ° C (in the refrigerator). Do not freeze.
Keep out of the reach of children.

Shelf life

Powder for suspension for oral administration - 2 years.
The prepared suspension is no more than 10 days.
Do not use after the expiration date printed on the package.

Conditions of leave from pharmacies

You can buy Arbidol powder without a prescription.