Arbidol caps. 100mg #20

Arbidol instruction for use

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Form of release, composition and packaging

Capsules of yellow color, size 3; contents of capsules - a mixture containing granules and powder from white to white with a greenish-yellowish or creamy hue of color.

pharmachologic effect

Antiviral drug. Specifically suppresses influenza A and B viruses, coronavirus associated with severe acute respiratory syndrome (SARS-associated coronavirus). By the mechanism of antiviral action refers to the inhibitors of fusion (fusion), interacts with the hemagglutinin of the virus and prevents the fusion of the lipid envelope of the virus and cell membranes. Has a moderate immunomodulatory effect. Has interferon-inducing activity, stimulates humoral and cellular immunity reactions, phagocytic function of macrophages, increases the body's resistance to viral infections. Reduces the incidence of complications associated with a viral infection, as well as exacerbations of chronic bacterial diseases.
Therapeutic efficacy in viral infections is manifested in a decrease in the severity of general intoxication and clinical phenomena, and in reducing the duration of the disease.
Has a moderate immunomodulatory effect.
Refers to low-toxic drugs (LD50> 4 g / kg). Does not have any negative effects on the human body when administered orally at recommended doses.

Pharmacokinetics

Suction and distribution

Quickly absorbed from the digestive tract. Cmax in blood plasma with the use of ufifenovir in a dose of 50 mg is achieved after 1.2 hours, in a dose of 100 mg - 1.5 hours.
Umifenovir is quickly distributed to the organs and tissues of the body.

Metabolism and excretion

Metabolised in the liver. T1 / 2 is 17-21 hours.
About 40% is excreted unchanged, mainly with bile (38.9%) and in an insignificant number - kidney (0.12%). During the first 24 hours, 90% of the dose is taken.

Indications

Prevention and treatment in adults and children:
- influenza A and B, acute respiratory viral infection, severe acute respiratory syndrome (SARS), incl. complicated by bronchitis and pneumonia;
- secondary immunodeficiency states;
- complex therapy of chronic bronchitis, pneumonia and recurrent herpetic infection.
Prevention of postoperative infectious complications and normalization of the immune status.
In the complex therapy of acute intestinal infections of rotavirus etiology in children older than 3 years.

Contraindications

- children's age till 3 years;
- Hypersensitivity to the components of the drug.

Dosage

The drug is administered orally, before meals. A single dose for adults and children over the age of 12 is 200 mg (2 capsules for 100 mg or 4 capsules for 50 mg), for children aged 6 to 12 years, 100 mg, and 3 to 6 years for 50 mg.

For non-specific prophylaxis

In direct contact with a patient with influenza and other acute respiratory viral infections, adults and children over 12 years of age Arbidol is prescribed at a dose of 200 mg / day; children aged 6 to 12 years - 100 mg / day; Children aged 3 to 6 years - 50 mg / day. The drug is taken 1 time / day. Course - 10-14 days.
During the epidemic of influenza and other acute respiratory infections, for the prevention of exacerbation of chronic bronchitis and relapse of herpes infection to adults and children over 12 years of age, the drug is prescribed in a single dose of 200 mg; children aged 6 to 12 years - 100 mg; Children aged 3 to 6 years - 50 mg. The drug is taken 1 dose 2 times a week for 3 weeks.
For the prevention of SARS (in contact with the patient), adults and children over 12 years of age are prescribed 200 mg 1 time / day for 12-14 days; children aged 6 to 12 years - 100 mg 1 time / day (before meals) for 12-14 days.
For the prevention of postoperative infectious complications, the drug is prescribed for two days before the operation, then on the second and fifth days after the operation, 1 dose: adults and children over 12 years of age - 200 mg, children from 6 to 12 years - 100 mg, 3 to 6 years - 50 mg.

For treatment

With flu and other acute respiratory infections without complications, adults and children over 12 years of age are prescribed 200 mg 4 times / day (every 6 hours), children aged 6 to 12 years - 100 mg 4 times / day (every 6 hours), from 3 to 6 years - 50 mg 4 times / day (every 6 hours). The course of treatment is 5 days.
For influenza and other acute respiratory infections, with the development of complications (including bronchitis, pneumonia) for adults and children over 12 years of age, Arbidol is prescribed 200 mg 4 times / day (every 6 hours) for 5 days, then 200 mg 1 time / wk. within 4 weeks. Children aged 6 to 12 years are prescribed 100 mg 4 times / day (every 6 hours) then - 100 mg 1 time / week. within 4 weeks. Children aged 3 to 6 years are prescribed 50 mg 4 times / day (every 6 hours) for 5 days, then 50 mg once a week. within 4 weeks.
To treat SARS, adults and children over 12 years of age are prescribed 200 mg twice a day for 8-10 days.
In the complex therapy of chronic bronchitis and recurrent herpetic infection, adults and children over 12 years of age receive the drug 200 mg 4 times / day (every 6 hours) for 5-7 days, then 200 mg twice a week. within 4 weeks. Children aged 6 to 12 years, 100 mg 4 times / day (every 6 hours) for 5-7 days, then - 100 mg 2 times / week. within 4 weeks. Children aged 3 to 6 years are prescribed 50 mg 4 times / day (every 6 hours) for 5-7 days; then - 50 mg 2 times / week. within 4 weeks.
In the complex therapy of acute intestinal infections of rotavirus etiology, children over 12 years of age are prescribed 200 mg 4 times / day (every 6 hours) for 5 days, at the age of 6 to 12 years - 100 mg 4 times / day (every 6 hours ) for 5 days, at the age of 3 to 6 years - 50 mg 4 times / day (every 6 hours) for 5 days.

Side effects

Rarely: allergic reactions.

Overdose

Cases of drug overdose were not noted.

Drug Interactions

When prescribed with other medicines, no negative effects were noted.

special instructions

Impact on the ability to drive vehicles and manage mechanisms
The drug does not show central neurotropic activity and can be used in medical practice for preventive purposes in practically healthy persons of various professions requiring increased attention and speed of psychomotor reactions (including transport drivers, operators).

Pregnancy and lactemia

Data on the use of Arbidol during pregnancy and during breastfeeding are not provided.

Application in childhood

Contraindicated: children under 3 years.

Conditions of leave from pharmacies

The drug is approved for use as a means of OTC.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature of no higher than 25 ° C. Shelf life - 2 years.
Description of the drug ARBIDOL is based on an approved instruction for use and approved by the manufacturer.