Vicks Active SymptoMax powder #10

Vicks Active SymptoMax instruction for use

You can buy Vicks Active SymptoMax on this page

Composition (per one sachet)

Active substances - paracetamol 1000 mg, phenylephrine hydrochloride 12,20 mg.
Auxiliary substances in blackcurrant powder - ascorbic acid, sucrose, citric acid, sodium citrate, aspartame, acesulfame potassium, blackberry-flavoring flavor S-133747, blackberry flavor 1007348, blackcurrant dye.
Auxiliary substances in lemon powder - ascorbic acid, sucrose, citric acid, sodium citrate, aspartame, acesulfame potassium, quinoline yellow colorant, lemon flavor F / 29088, lemon flavor F / 29089, lemon flavor F / 28151, lemon flavor F / 501.476 / AP0504.

Description

Black-currant powder: a fine-grained powder of light purple color with a characteristic smell of black currant.
Powder lemon: a fine crystalline powder of light yellow color with a characteristic smell of lemon.
A solution of blackcurrant powder: red-violet with a characteristic smell of black currant.
A solution of lemon powder: yellow with a characteristic smell of lemon, with opalescence.

Pharmacotherapeutic group:

Remedy for elimination of symptoms of acute respiratory disease and "colds" (analgesic non-narcotic remedy + alpha-adrenomimetic).
ATX Code: N02BE51

Pharmacological properties of Vicks Active SymptoMax

Pharmacodynamics

Combined drug, the effect of which is due to the composition of its components.
Paracetamol has an analgesic and antipyretic effect, these effects are due to inhibition of the synthesis of prostaglandins in the central nervous system.
Phenylephrine is a postsynaptic alpha-adrenoreceptor agonist with low cardioselective affinity for beta receptors. Decongestant, narrows vessels, eliminates puffiness and flushing of the mucous membrane of the nasal cavity.

Pharmacokinetics

Paracetamol is rapidly and completely absorbed in the small intestine. The maximum concentration in the blood is observed 15-20 minutes after ingestion. Systemic bioavailability is determined by presystemic metabolism and, depending on the dose, ranges from 70% to 90%. Paracetamol rapidly spreads across all tissues of the body and has a half-life of about 2 hours. Metabolised in the liver and excreted in the urine in the form of glucuronides and sulfate compounds (> 80%).
Phenylephrine is rapidly absorbed from the gastrointestinal tract. The level of primary metabolism is quite high (≈60%), therefore the oral use of phenylephrine reduces its bioavailability (≈40%). The maximum concentration in the blood plasma is observed after 1-2 hours, and the half-life period varies from 2 to 3 hours. It is excreted in the urine in the form of sulfate compounds. Oral reception of phenylephrine as decongestant should be carried out with an interval of 4-6 hours.

Indications for use

Symptoms of "colds" and flu: headache, sore throat, other types of pain, nasal congestion, fever.

Contraindications for Vicks Active SymptoMax

Hypersensitivity to paracetamol or other components of Vicks Active SymptoMax;
Arterial hypertension;
Cardiac ischemia;
Violation of liver function and pronounced impaired renal function;
Hyperthyroidism;
Diabetes;
Phenylketonuria (because Vicks Active SymptoMax contains aspartame);
Simultaneous reception of tricyclic antidepressants, monoamine oxidase (MAO) inhibitors or beta-blockers or their administration during the last 2 weeks;
Pregnancy and the period of breastfeeding;
Hyperplasia of the prostate;
Glaucoma;
Age to 18 years;
Deficiency of sugar / isomaltase;
Intolerance to fructose;
Glucose-galactose malabsorption.

Carefully

Long-term use of Vicks Active SymptoMax is not recommended. It is necessary to avoid simultaneous administration of other anti-cold and / or paracetamol-containing drugs. Do not take the drug while taking alcohol.
Bronchial asthma, COPD (chronic obstructive pulmonary disease), deficiency of glucose-6-phosphate dehydrogenase, blood diseases, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson a, Rotor), hyperoxaluria. Application in pregnancy and during breastfeeding
Do not use Vicks Active SymptoMax during pregnancy and during breastfeeding.

Dosing and Administration

Dissolve the contents of one sachet in hot, but not boiling water (250 ml). Allow to cool to an acceptable temperature and drink.
Adults and children over 18 years old - one sachet. If necessary, repeat the reception every 4-6 hours, but not more than 4 doses (sachets) per day.
Vicks Active SymptoMax is not recommended for more than 5 days as an anesthetic and 3 days as an antipyretic agent without consulting a doctor.
If symptoms persist, consult a physician.

Side effects of Vicks Active SymptoMax

Paracetamol

Allergic reactions Rare: skin rash, hives, anaphylaxis, bronchospasm, angioedema.
From the side of the central nervous system Rarely: dizziness.
From the hemopoietic system Rarely: aplastic anemia, methemoglobinemia, increased blood pressure. Very rarely: pathological changes in the blood, such as thrombocytopenia, agranulocytosis, hemolytic anemia, neutropenia, leukopenia, pancytopenia.
From the side of the digestive system Rarely: nausea, vomiting, dryness of the oral mucosa, hepatotoxic effect.
From the urinary system Seldom: urinary retention, nephrotoxicity (papillary necrosis).
Other Rarely: paresis of accommodation, increased intraocular pressure, mydriasis.

Phenylephrine

From the cardiovascular system Rarely: tachycardia, increased blood pressure.
From the side of the nervous system Rarely: insomnia, nervousness, tremor, anxiety, increased excitability, confusion, irritability and headache.
From the digestive system Often: anorexia, nausea and vomiting.
From the immune system and skin Rarely: allergic reactions, including skin rashes, hives, anaphylaxis and bronchospasm.

Overdose with Vicks Active SymptoMax

Paracetamol

Liver involvement is possible in adults who take 10 or more grams of paracetamol. Taking 5 or more grams of paracetamol can cause liver damage if there are risk factors: prolonged treatment with carbamazepine, phenobarbital, phenytoin, primidon, rifampicin, or other drugs that induce liver enzymes, alcohol abuse, glutenion deficiency (eg, malnutrition), cystic fibrosis, HIV -infection, starvation, cachexia.
Symptoms of paracetamol overdose in the first 24 hours: blanching, nausea, vomiting, anorexia and abdominal pain.
Liver damage can occur between 12 and 48 hours after application of the drug. In case of an overdose of paracetamol, despite the absence of primary symptoms of an overdose, it is necessary to seek qualified help in medical institutions. To prevent serious consequences of overdose, it is necessary to take the necessary measures in time.
Symptoms may manifest only partially as nausea or vomiting, and may not reflect the actual degree of overdose or the risk of organ damage.
With severe overdose - liver failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis.

Phenylephrine

Symptoms of an overdose of phenylephrine include irritability, headache, increased blood pressure.
In case of the above symptoms of an overdose, it is necessary to consult a doctor.
Treatment: the introduction of donors of SH-groups and precursors of the synthesis of glutathione-methionine for 8-9 hours after an overdose and acetylcysteine ​​- for 8 hours. The need for additional therapeutic measures (further introduction of methionine, intravenous injection of acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

Interaction Vicks Active SymptoMax with other drugs

Paracetamol

Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which allows the development of severe intoxications.
Paracetamol increases the effect of anticoagulants of indirect action and reduces the effectiveness of uricosuric medicines.
The rate of absorption of paracetamol is increased by metoclopramide or domperidone, and decreases with the action of colestyramine.
Anticoagulant effect of warfarin and other derivatives of coumarins is enhanced with prolonged use of paracetamol.
Vicks Active SymptoMax enhances the effects of MAO inhibitors, sedatives, ethanol.

Phenylephrine

With the simultaneous use of phenylephrine with antidepressants, antiparkinsonian, antipsychotic drugs, phenothiazine derivatives, urine retention, dryness of the oral mucosa, constipation is possible.
When used with glucocorticosteroids, the risk of developing glaucoma increases.
Tricyclic antidepressants increase the adrenomimetic effect of phenylephrine, the simultaneous administration of halothane increases the risk of ventricular arrhythmia.

special instructions

Vicks Active SymptoMax should not be combined with taking ethanol.
During the treatment period it is necessary to refrain from taking sleeping pills, anxiolytic drugs, as well as other drugs containing paracetamol.
The drug distorts the results of laboratory tests evaluating the concentration of glucose and uric acid in the plasma.
Contains sucrose. Vicks Active SymptoMax is contraindicated in patients with a rare congenital intolerance to fructose, with a violation of absorption of glucose-galactose or with a deficiency of sucrose-isomaltase.
Contains aspartame (E951), a source of phenylalanine. May be toxic to patients with phenylketonuria.
When driving vehicles and engaging in other potentially hazardous activities, it is necessary to take into account that Vicks Active SymptoMax can cause side effects such as dizziness and confusion.

Form of issue

Powder for solution for oral administration [blackcurrant, lemon].
5.0 g of powder in a laminated bag.
For 5 or 10 bags together with the instructions for use are placed in a cardboard box.

Storage conditions

At a temperature of no higher than 25 ° C. Keep out of the reach of children.
Shelf life - 3 years.
Do not use after expiry date.

Conditions of leave from pharmacies

To buy Vicks Active SymptoMax the prescription is not required.