Vicks Active Symptomax Plus powder #10

Vicks Active Symptomax Plus instruction

You can buy Vicks Active Symptomax Plus here

pharmachologic effect

Vicks Active Symptomax Plus is a complex medication used in acute respiratory infections. Vicks Active Symptomax Plus contains paracetamol, guaifenesin and phenylephrine hydrochloride.
Paracetamol is a non-narcotic analgesic with a pronounced antipyretic and analgesic effect. The anti-inflammatory result of paracetamol is negligible (the substance is inactivated by cellular peroxidases). Paracetamol lowers the activity of cyclooxygenase and disrupts the synthesis of prostaglandins and prostacyclins from arachidonic acid, thus slowing down the generation and carrying of pain impulses, and also reducing the excitability of the thermoregulatory center.
Guaifenesin is a mucolytic drug that increases the volume and reduces the viscosity of phlegm, and also facilitates the excretion of sputum from the respiratory tract. Guaifenesin lowers the number of coughing attacks, improves expectoration and reduces irritation of the respiratory tract.
Phenylephrine hydrochloride is a sympathomimetic agent that stimulates the alpha-adrenergic receptors of the vessels of the nasal mucosa. Phenylephrine hydrochloride helps to reduce edema and hyperemia of the nasal mucosa, reduces the severity of rhinorrhea and facilitates nasal breathing.
The effect of the medicine Vicks Active Symptomax Plus develops within 20-30 minutes and lasts up to 6-12 hours.
Active components of the medicine Vicks Active Symptomax Plus are normally absorbed in the intestine. Metabolized paracetamol and phenylephrine hydrochloride in the liver. Excreted active substances in the main kidneys in the form of derivatives and unchanged. The half-life of paracetamol reaches 4 hours, guaifenesin - 1 hour. In healthy volunteers, paracetamol is completely excreted within 24 hours.
Paracetamol penetrates through the hematoplacental and blood-brain barrier.

Indications for use

Vicks Active Symptomax Plus is used as a symptomatic agent in the therapy of patients with productive cough (with difficult sputum), rhinorrhea, sore throat, muscle and headache, fever and other symptoms of acute respiratory infections and flu.

Dosing and Administration

Vicks Active Symptomax Plus taken orally. Immediately before taking the contents of the sachet dissolve in a glass of warm drinking water (150-200 ml, depending on the amount of liquid that the patient can drink at a time). The finished solution should not be stored. The preparation Vicks Active Symptomax Plus is taken regardless of the meal. The duration of the course of therapy and the regimen of taking the medicine Vicks Active Symptomax Plus is determined by the doctor.
Adult patients, adults and children over the age of 12, are generally prescribed to take 1 packet of Vicks Active Symptomax Plus up to 4 times a day.
It is necessary to observe an interval of at least 4 hours between doses of the medicine Vicks Active Symptomax Plus.
The maximum daily dosage is 4 sachets. If the daily dosage is exceeded or the intervals between doses are shortened, the risk of side effects and overdose increases substantially.
The recommended maximum duration of therapy with Vicks Active Symptomax Plus is 5 days. If within 3 days after the start of treatment with the drug, no positive dynamics are seen, it is necessary to consult a doctor to clarify the diagnosis and the therapy regimen.

Side effects

During the period of therapy with the drug Vicks Active Symptomax Plus, the following side effects are likely to develop in patients:
On the part of the system of blood and cardiovascular system: methemoglobinemia, anemia, sulfgemoglobinemia, thrombocytopenia, neutropenia, leukopenia, pancytopenia, tachycardia, palpitation, arterial hypertension.
From the side of the central nervous system: limb tremor, headache, anxiety, insomnia, disorientation, dizziness and psychomotor agitation (these effects often develop when taking high doses).
On the part of the digestive system: pain and discomfort in the epigastrium, vomiting, nausea, anorexia, hepatonecrosis, elevation of the level of hepatic enzymes.
Allergic reactions: bronchospasm, urticaria, erythematous rash, toxic epidermal necrolysis, Quincke's edema, multiforme exudative erythema.
Others: retention of urine (mainly in patients with prostatic hyperplasia), hypoglycemia (up to the hypoglycemic crisis).
With the development of side effects of the drug Vicks Active Symptomax Plus should consult with a doctor about the possibility of further therapy.

Contraindications

Vicks Active Symptomax Plus is not prescribed for patients with intolerance to active or additional powder ingredients, as well as drugs from a group of non-narcotic analgesics.
Vicks Active Symptomax Plus is contraindicated in patients with intolerance to fructose and phenylketonuria.
Vicks Active Symptomax Plus is not used in the treatment of patients with diabetes mellitus, hypertension, cardiovascular disease, prostatic hyperplasia, hyperthyroidism, zakratougolnoy glaucoma and pheochromocytoma.
Vicks Active Symptomax Plus should not be prescribed to persons with kidney and liver disease, alcoholism, and patients who receive monoamine oxidase inhibitors and inducers of microsomal liver enzymes.
Veks Active Symptomax Plus in pediatrics is used only to treat patients who are already 12 years old.

Pregnancy

Vicks Active Symptomax Plus should not be used in the treatment of pregnant women and women who breastfeed.

Interaction with other drugs

Vicks Active Symptomax Plus can not be used concomitantly with monoamine oxidase inhibitors and for the last 2 weeks after the end of the course of therapy the latter (due to the risk of hypertensive crisis).
Vicks Active Symptomax Plus should not be administered in combination with inducers of liver enzymes and ethyl alcohol due to an increased risk of developing hepatotoxicity of paracetamol.
Paracetamol with simultaneous use with anticoagulants intensifies their result and increases the risk of bleeding (with a single and short-term use of paracetamol, this result is poorly expressed).
Metoclopramide and domperidone increase intestinal absorption of paracetamol when combined with admission.
Cholestyramine when used concomitantly with the Vicks Active Symptomax Plus can reduce the intestinal absorption of paracetamol.
Phenylephrine can reduce the effectiveness of beta-blockers and antihypertensives.
Phenylephrine hydrochloride, when used at the same time, enhances the effect of sympathomimetic drugs (including intranasal use) on the cardiovascular system.

Overdose

With the use of overestimated doses of Vicks Active Symptomax Plus, patients are likely to develop intoxication with paracetamol, phenylephrine hydrochloride or guaifenesin.

Overdose of paracetamol:

The toxic dosage of paracetamol is 10 g (for patients receiving inducers of microsomal liver enzymes, as well as patients with malnutrition, alcoholism, HIV infection, cystic fibrosis and cachexia, the toxic dosage is reduced to 5 g of paracetamol). When taking excessive doses of paracetamol, patients develop pain in the abdominal region, headache, vomiting and nausea, pallor of the skin, and liver damage. In severe paracetamol intoxication, glucose metabolism, hepatic encephalopathy, metabolic acidosis, respiratory depression, acute renal failure, coma, and death are likely to develop.
Treatment: gastric lavage, monitoring the patient's condition (with severe intoxication, hospitalization is indicated), the appointment of enterosorbents. If necessary, prescribe specific antidotes - methionine and N-acetylcysteine.
The patient should be monitored for at least 48 hours after an overdose and, if necessary, to prescribe symptomatic therapy.

Overdose of phenylephrine hydrochloride:

When taking high doses of phenylephrine hydrochloride, patients develop headaches, feelings of fear, anxiety, anxiety, sleep disorders, as well as arrhythmias, bradycardia and lability of blood pressure.
Treatment: gastric lavage, monitoring the patient's condition, the appointment of enterosorbent and symptomatic agents.

Overdose of guaifenesin:

When taking high doses of guaifenesin, patients develop vertigo, digestive tract disorders, as well as agitation, impaired consciousness and respiratory depression.
Treatment: symptomatic therapy and monitoring of the patient's condition.

Form of issue

Powder for solution preparation for oral use Vicks Active Symptomax Plus in sachets made of paper, polymer film and laminated foil, 5 or 10 sachets are put into cardboard pack.

Storage conditions

Vicks Active Symptomax Plus should be stored in places inaccessible to children, where the temperature is maintained between 15 and 25 degrees Celsius.
Vicks Active Symptomax Plus is suitable for 3 years after manufacture.
Ready-to-use solution for oral administration Vicks Active Symptomax Plus is not subject to storage.

Composition

1 sachets with powder for oral solution Vicks Active Symptomax Plus contains:
Paracetamol - 500 mg;
Guaifenesin - 200 mg;
Phenylephrine hydrochloride - 10 mg;
Additional substances, including sucrose and aspartame.

Terms of sell

You can buy Vicks Active Symptomax Plus without a prescription.