Grippostad powder 5gr #5

Grippostad instruction

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See also - Grippostad C

Composition

Grippostad includes ascorbic acid and paracetamol, as well as the following additional components: ethylcellulose, silicon colloidal dioxide, aspartame, sucrose, citric acid, lemon flavor.

Form of issue

The medicine is available in the form of powder in bags, from which a solution for internal use is prepared.

pharmachologic effect

Grippostad is an analgesic.

Pharmacodynamics and pharmacokinetics

Paracetamol, which is part of this combination drug, is characterized by an analgesic and antipyretic effect. Another active component - ascorbic acid - actively participates in the regulation of oxidation-reduction processes, blood coagulation, carbohydrate metabolism, tissue regeneration. In addition, it affects the synthesis of steroid hormones, reduces the degree of vascular permeability, increases immunity. Ascorbic acid also reduces the need for vitamins A, B1, B2, E; pantothenic acid, folic acid.
It promotes better tolerability of paracetamol and prolongs its action, slowing the excretion from the body.

Indications for use

Grippostad is used in case of febrile syndrome with infectious and inflammatory diseases. It is also indicated in the case of a pain syndrome with a mild or moderate degree of severity, for example, with headache and toothache, myalgia, algodismenia, migraine, neuralgia, arthralgia.

Contraindications

You can not use the drug for prostatic hypertrophy with the formation of residual urine, lack of glucose-6-phosphate dehydrogenase, hypersensitivity to its components, portal hypertension, pregnancy (I and III trimester), breastfeeding, bleeding from the gastrointestinal tract, renal failure, zakratougolnoy glaucoma, uncontrollable arterial hypertension, severe arrhythmia, phenylketonuria, diseases of the hematopoiesis system, under 12 years of age, weight of the case up to 40 kg.
With caution, the drug is acceptable for erosive and ulcerative lesions of the gastrointestinal tract, congenital hyperbilirubinemia, liver failure, alcoholism.

Side effects

Grippostad can provoke the following side effects: allergies, epigastric pain, thrombocytopenia, nausea, anemia, agranulocytosis. If the drug is taken for a long time in large doses, it can lead to the development of unwanted hepatotoxic effects, aplastic anemia, pancytopenia, hemolytic anemia, methemoglobinemia, nephrotoxicity.

Instructions for use Grippostad (Method and dosage)

The instruction to Grippostad informs that the medicine is taken internally. The contents of the sachet are poured into a container, and then poured with some warm water or tea. Mix the mixture and drink immediately. It can be prepared and taken 3-4 times a day with an interval of 4-8 hours. Instructions for use Grippostad indicates that the maximum daily dosage for adults is 6 packets. Children are given not more than 10-15 mg / kg at a time. Depending on the age, the following dosages are indicated:
    6-9 years (weight about 22-30 kg) - half a pack at a time, maximum daily dose - 2 sachets;
    10-12 years (weight about 30-40 kg) - one sachet per time, maximum daily dose - 3 sachets;
    from 12 years (weight from 40 kg) - one sachet at a time, the maximum daily dose - 4 sachets.
For people with Gilbert's syndrome, as well as liver / kidney dysfunction, the dose of the drug reduces or increases the time interval between sachets.
In case of severe renal insufficiency, the time interval between doses is at least 8 hours.
It should be borne in mind that taking the product immediately after eating leads to a delay in its action.
The medicine can not be used for more than three consecutive days without the recommendation of a specialist. If symptoms do not go away within three days, it is advisable to consult a doctor.

Overdose

During the day after an overdose, the following manifestations may occur: excessive pallor of the skin, vomiting, abdominal pain, metabolic acidosis, nausea, anorexia, a violation of glucose metabolism. Within 1-2 days, liver function disorders may occur. In case of severe overdose, liver failure with encephalopathy may develop. In addition, acute renal failure with tubular necrosis, coma, pancreatitis, arrhythmia, and death are possible. Hepatotoxic effect in adult patients develops when taking the drug at a dosage of 10 g or more.
As a treatment, the use of Glutathione precursors and SH-group donors is shown for 8-9 hours after taking the drug in excess dosages. In addition, inject acetylcysteine ​​within 8 hours after an overdose. The need for additional therapeutic measures is determined by a specialist individually. It depends on the level of paracetamol in the blood, as well as on how much time passed after an overdose.

Interaction

You can not combine the medication with other non-narcotic analgesics, barbiturates, Rifampicin, non-steroidal anti-inflammatory drugs, antiepileptic drugs and chloramphenicol.
Prolonged combination with NSAIDs increases the likelihood of the terminal stage of renal failure, the appearance of analgesic nephropathy, and the development of renal papillary necrosis.
Do not take the drug for a long time in high dosages together with salicylates. This significantly increases the likelihood of developing kidney and bladder cancer.
Interaction with Diflunisal increases the content of the drug in blood plasma by 50%. This increases the risk of hepatotoxicity. The same effect is obtained by combination with myelotoxic drugs. Inhibitors of microsomal hepatic enzymes, on the contrary, reduce the likelihood of a hepatotoxic effect.
In turn, inducers of microsomal hepatic enzymes increase the production of hydroxylated active metabolites. This makes the development of severe intoxication more likely even with a slight overdose of Grippostad.
The combination of the drug with ethanol not only enhances the hepatotoxic effect of paracetamol, but it can also trigger the appearance of acute pancreatitis.
Grippostad reduces the effect of uricosuric medicines and increases the degree of toxicity of Chloramphenicol. It can also enhance the effect of indirect anticoagulants.
The degree of absorption of paracetamol is increased by the action of metoclopramide and, conversely, decreases under the influence of agents that slow the emptying of the stomach.

Terms of sale

You can buy Grippostad without a prescription.

Storage conditions

The medicine must be stored in a dry and dark place. The optimum temperature is up to 25 ° C.
Shelf life - five years. Do not use sachets of powder after the expiry date indicated on the package.

Reviews

Opinions on this medication are mainly positive. Those who took the drug, note its rapid action and effectiveness. Among the positive moments also indicate that the medicine is very pleasant to the taste. Some patients, however, complain that a drink with powder is required to drink hot, and the effect is not very long.