Grippostad C caps 375.5mg #10

Instruction for Grippostad C

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Composition

Grippostad C includes paracetamol, caffeine, ascorbic acid and chlorpheniramine maleate.
Additional substances: lactose monohydrate, gelatin, glycerol tristearate. The composition of the shell includes gelatin, titanium dioxide, water, a dye yellow "Sunset Sun".

Form of issue

The medicine is issued in the form of capsules, which are contained in contour packs, enclosed in a cardboard pack.

pharmachologic effect

Grippostad C is characterized by analgesic, restorative, antiallergic, antipyretic and antispasmodic action.

Pharmacodynamics and pharmacokinetics

The drug helps reduce the severity of symptoms of influenza and ARVI. It is effective against rhinorrhea, as well as muscle and headaches. The intake of capsules contributes to the normalization of temperature.
Paracetamol, which is part of the drug, is an analgesic, which has an antipyretic effect. It blocks both isoforms of the enzyme cyclooxygenase, which leads to a disruption in the production of prostaglandins, thromboxane and prostacyclin. The decrease in the concentration of prostaglandins at the center of thermoregulation in the hypothalamus promotes normalization of body temperature, and a decrease in their content in the tissues of the nervous system causes inhibition of generation and pain impulse.
Another active substance of the drug - caffeine - stimulates the central nervous system. It increases the working capacity of the body and the tone of the vessels, as well as eliminates drowsiness and stimulates the work of the heart. In addition, caffeine increases the analgesic effect of NSAIDs.
Ascorbic acid increases the immune defense of the body, has an antioxidant effect and participates in carbohydrate metabolism. Its application leads to an increase in the nonspecific immune response, improves the regeneration of cells and protects them from the negative effects of peroxide compounds and free radicals.
Chlorpheniramine hydrochloride inhibits H1-histamine receptors and reduces the severity of manifestations, which are caused by the release of histamine. This active ingredient also helps to reduce the swelling of the nasal mucosa, facilitates nasal breathing and successfully eliminates rhinorrhea.
The active substances of the drug, getting into the body, are well absorbed into the systemic bloodstream. Paracetamol is biotransformed in the liver, resulting in the formation of pharmacologically inactive substances. The components of the capsules are excreted mainly through the kidneys in the form of metabolites and in unchanged form.

Indications for use

Grippostad C is taken with a mild or mild pain syndrome, for example, in case of headaches, neuralgia, sore throat. In addition, this tool is shown for influenza and ARVI. Whether it is necessary to use capsules as an antipyretic agent is decided in each case individually, depending on the severity, tolerability and nature of the fever.

Contraindications

The drug is contraindicated in case of hypersensitivity of the organism to its components and other NSAIDs, lactose insufficiency, malabsorption syndrome of glucose-galactose, galactosemia, renal and hepatic dysfunction, glucose-6-phosphate dehydrogenase deficiency, closed-angle glaucoma, hyperbilirubinemia, hematopoiesis.
It is not desirable to take medicine for people with heart rhythm disturbances, as well as for chronic alcoholism, atherosclerosis, sinoatrial blockade, arterial hypertension, insomnia, atrioventricular blockade, decompensated heart failure.
Also capsules are contraindicated in case of diabetes mellitus, exacerbation of duodenal ulcer and stomach, acute form of pancreatitis. You can not take Grippostad C at the age of 12 years.
Take the drug with caution should the elderly, patients with malnutrition, as well as patients who have recently suffered serious illnesses or surgical interventions.
During therapy with this drug, it is desirable to avoid driving and potentially unsafe mechanisms.

Side effects

If you use the drug strictly according to the instructions, it is well tolerated by most patients.
The following side effects are possible: skin allergic reactions, dry mouth, disruption of the gastrointestinal tract, difficulty urinating. In rare cases, leukopenia and thrombocytopenia are reported. With prolonged use in high dosages, the drug can cause kidney and liver dysfunction. In some cases, such negative reactions to paracetomol as a person's face swelling, nausea, marked decrease in pressure, hyperhidrosis, asphyxia have been documented.

Instructions for use (Method and dosage)

Capsules should be taken orally, with a certain amount of water. Usually a single dose - 2 capsules. If necessary, after 4-6 hours, you can take the same dosage. There should be no more than 4 receptions per day. Do not exceed the daily dose of 12 capsules.
The medicine must be swallowed whole without chewing. Do not drink capsules with milk or juices. Their use is possible regardless of meals, but experts recommend doing this after meals to reduce the likelihood of undesirable effects on the part of the gastrointestinal tract.
The duration of the course is determined by a specialist individually. But it is advisable not to continue treatment for more than 5 consecutive days. If you need a long-term medication, you need to monitor the picture of peripheral blood, the kidneys, the liver, as well as the functions of the cardiovascular and respiratory systems.
In case of pain, 1-2 capsules should be taken once.
Dosages are adjusted for patients with kidney / liver dysfunction, as well as depleted and elderly people.
If within 3 days of the beginning of the course there is no improvement, it is necessary to review the scheme of taking the medicine.

Overdose

When an overdose of the drug there are symptoms of acute poisoning: nausea, pain in the abdomen, heart palpitations, skin pallor, vomiting, hyperhidrosis. After 1-2 days, signs of liver damage may appear. In acute overdose, renal failure and coma are observed.
As a treatment for the first four hours, the patient is prescribed gastric lavage, and adsorbents can also be taken.

Interaction

You can not combine Grippostad C with other drugs that include non-steroidal anti-inflammatory substances. In addition, it is not desirable to simultaneously take this drug with barbiturates, Levomycetin, Rifampicin and antiepileptic drugs.
Interaction with Metoclopramide leads to an acceleration of absorption of paracetamol from the intestine. The opposite effect gives the reception of cholestyramine.
Combination with Zidovudine should be administered with caution.
The toxicity of paracetamol is increased by the action of Probenecid, drugs that induce liver enzymes, salicylates, as well as drugs with a hepatotoxic effect.
Paracetamol can enhance the effect of oral anticoagulants. And in combination with sleeping pills, neuroleptics, tranquilizers and other means, depressing the central nervous system, the effect of chlorpheniramine on the nervous system may increase.
Chlorpheniramine also enhances the effect of antispasmodics, antiparkinsonian drugs, Atropine and tricyclic antidepressants.
The concentration of caffeine in the blood plasma increases when combined with barbiturates and nicotine, and, conversely, decreases in the case of interaction with oral contraceptives, disulfiram and cimetidine. Caffeine is also able to increase the content of Teofillin in the plasma and the additive potential of the substances of the ephedrine series.
The degree of absorption of ascorbic acid decreases when combined with alkaline drinks and juices, as well as the intake of oral contraceptives.
Grippostad C can affect the effects of Heparin and indirect anticoagulants. And with its combination with salicylates, the probability of the appearance of crystalluria increases. In addition, the risk of iron toxicity increases with the administration of Grippostad C capsules together with deferoxamine and increases the absorption of tetracyclines, iron and penicillin from the intestine.

Terms of sale

The medicine is sold without a prescription.

Storage conditions

Store the drug at a temperature of up to 25 ° C.
Shelf life - 5 years.

Reviews

Reviews about this drug are usually positive. Those who tried the drug, note its rapid action and effectiveness. About adverse reactions it is informed extremely seldom.