MIG 400 tabs 400mg #20

Instruction for MIG 400 tablets

Reed more and buy MIG 400 on this page

Composition

The active component of the drug is ibuprofen.
Additional constituents are silicon colloidal dioxide, corn starch, sodium carboxymethyl starch, magnesium stearate.
The envelope includes hypromellose, povidone K30, titanium dioxide, macrogol 4000.

Form of issue

The drug is sold in the form of tablets, which are covered with a shell.

pharmachologic effect

The drug is a non-steroidal anti-inflammatory drug.

Pharmacodynamics and pharmacokinetics

Mig 400 tablets contain ibuprofen, which is an analgesic with antipyretic and anti-inflammatory properties. It indiscriminately inhibits COX-1 and COX-2, as well as the synthesis of prostaglandins.
Analgesic properties of the drug are most pronounced in inflammatory pains. Analgesic effect does not apply to the narcotic type.
After taking the pills inside the medicine is well absorbed from the digestive tract. The maximum plasma concentration of the active ingredient is reached approximately 120 minutes after taking the tablets at a dosage of 400 mg.
Connection with blood plasma proteins by 99%. The active component is slowly distributed in the synovial fluid. It is biotransformed in the liver by carboxylation and hydroxylation of the isobutyl group. Pharmacologically inactive metabolites are formed.
The half-life of plasma is 2-3 hours. In the form of metabolites and their conjugates is excreted in the urine. A small part of the drug is excreted unchanged in urine and bile.

Indications for use

The drug is indicated for use when:
    headache;
    toothache;
    pain in muscles and joints;
    fever for colds and flu;
    migraine;
    neuralgia;
    menstrual pain.
If necessary, find out what the Mig 400 tablets will help in each case, it is advisable to consult a doctor.

Contraindications

This remedy is prohibited for use when:
    hemorrhagic diathesis;
    hypersensitivity to the components of the drug;
    erosive and ulcerative lesions of the gastrointestinal tract;
    hemophilia and other disorders of blood clotting;
    pregnancy;
    age under 12 years;
    breastfeeding;
    a negative reaction to acetylsalicylic acid and other NSAIDs in the anamnesis;
    aspirin asthma;
    bleeding;
    lack of glucose-6-phosphate dehydrogenase;
    diseases of the optic nerve.
With caution, the drug should be used in old age, as well as in case of arterial hypertension, hepatic or renal insufficiency, hyperbilirubinemia, gastritis, colitis, heart failure, liver cirrhosis with portal hypertension, nephrotic syndrome, stomach and duodenal ulcers (including anamnesis ), enteritis, blood diseases.

Side effects

The use of Mig 400 can lead to the appearance of the following adverse reactions:
    GIT: vomiting, pain in the abdomen, decreased appetite, nausea, flatulence, heartburn, diarrhea, constipation;
    sensory organs: dryness or irritation of the eyes, hearing loss, toxic lesions of the optic nerve, ringing or tinnitus, blurred vision, edema of the conjunctiva and eyelid;
    CCC: heart failure, high blood pressure, tachycardia;
    allergy: rash, Quincke's edema, dyspnea, anaphylactic shock, erythema multiforme exudative, eosinophilia, pruritus, anaphylactoid reactions, bronchospasm, fever, Lyell's syndrome, rhinitis;
    changes in laboratory parameters: increased serum creatinine concentration, increased bleeding time, decreased hemoglobin level, decreased creatinine clearance, increased activity of liver transaminases, decreased serum glucose, decreased hematocrit;
    respiratory organs: dyspnea, bronchospasm;
    CNS: insomnia, headache, nervousness, psychomotor agitation, depression, hallucinations, dizziness, anxiety, irritability, drowsiness, impaired consciousness;
    urinary system: allergic nephritis, acute renal failure, cystitis, nephrotic syndrome, polyuria;
    hemopoietic system: thrombocytopenic purpura, anemia, leukopenia, thrombocytopenia, agranulocytosis.
In rare cases, the ulceration of the mucosa of the gastrointestinal tract, pain in the mouth, aphthous stomatitis, hepatitis, irritations or dryness of the oral mucosa, ulceration of the gingival mucosa, pancreatitis, aseptic meningitis is reported.
With prolonged use of the drug in high doses, the likelihood of ulceration of the gastrointestinal mucosa, visual impairment, and bleeding increases.

Instructions for use Mig 400 (Method and dosage)

The medicine is used inside. For those who take Mig 400 tablets, the instructions for use tell you that the dosages are set individually, depending on the indications.
Usually start taking the drug with 200 mg every day 3-4 times. If necessary, the dosage can be increased to 400 mg, which are taken 3 times a day. When the therapeutic effect is achieved, the daily dosage is reduced to 600-800 mg.
Instruction for use Mig 400 reports that it can not be taken for longer than a week or at higher dosages without consulting a specialist.
With dysfunction of the kidneys, heart or liver, the dose is reduced.

Overdose

When the drug is used in doses above the norm, abdominal pain, vomiting, drowsiness, headaches, metabolic acidosis, acute renal failure, bradycardia, atrial fibrillation, nausea, retardation, depression, tinnitus, coma, marked pressure decrease, tachycardia, respiratory arrest .
If after an overdose less than 60 minutes have passed, the stomach is washed. In addition, an alkaline drink, reception of Activated Carbon, forced diuresis is shown. Treatment is symptomatic.

Interaction

When taking Mig 400, a decrease in the effect of Furosemide and thiazide diuretics is possible, which can be caused by sodium retention due to inhibition of the synthesis of prostaglandins.
In addition, the active substance of the drug may enhance the effect of oral anticoagulants. Their joint reception is not desirable.
Ibuprofen also reduces the antiplatelet effect of acetylsalicylic acid and reduces the effectiveness of antihypertensive drugs.
Mig 400 should be used with caution in combination with NSAIDs and GCS, as this can lead to the occurrence of adverse reactions from the gastrointestinal tract.
The drug also provokes an increase in the level of Methotrexate in blood plasma.
In HIV-infected patients with hemophilia, the combination of ibuprofen with Zidovudine increases the risk of hemarthrosis.
The combination with Tacrolimus increases the likelihood of developing a nephrotoxic effect due to inhibition of prostaglandin synthesis.
Under the influence of Mig 400, the hypoglycemic properties of oral hypoglycemic drugs and insulin are enhanced. You may need to adjust the dosage.

Terms of sale

You can buy MIG 400 without a prescription.

Storage conditions

Storage temperature up to 30 ° C. The medicine must be kept in a place protected from the sun.
Shelf life - three years.

Reviews about Mig 400

On the Internet, there are various opinions about this drug. Some reviews of the Mig 400 report that the pills effectively help with headaches and toothaches, and some that the remedy has not been given proper effect. Sometimes there are reports of adverse manifestations, mainly, of skin allergic reactions. In addition, in some reviews it is told that the drug effectively helped to cope with the headache in just half an hour, but did not last long.