Nimesulid tabs 100mg #20

Nimesulid user manual

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Composition

Nimesulid tablets contain 100 mg of active ingredient Nimesulid, as well as auxiliary substances.

Form of issue

Produced in the form of tablets.
The active substance in the form of a powder (granules for the preparation of a suspension) is contained in preparations Nyz, Nimesil, Nemuxle.
In the form of a gel (ointment), the active substance is contained in the preparations Naise and Nimulide.

pharmachologic effect

Nimesulid - what is it?

Nonsteroidal, inflammatory agent. The drug has antiplatelet, antipyretic, analgesic and anti-inflammatory effects.

Pharmacodynamics and pharmacokinetics

The principle of action is aimed at inhibition of the synthesis of prostaglandins in the inflammatory focus, selective inhibition of cyclooxygenase-2.

Indications for use of Nimesulid

From what tablets?

Indications for the use of Nimesulid are: osteoarthritis, rheumatoid arthritis, bursitis, tendonitis, arthritis of various genesis. The drug is prescribed for relief of acute pain syndrome with myalgia, algodismenore, toothache, arthralgia, headache, in the postoperative period. The drug does not affect the progression of the disease, is effectively used to reduce the severity of the inflammatory process, to reduce pain, and also as symptomatic therapy.

Contraindications

Nimesulid is not prescribed for erosive and ulcerative diseases of the digestive tract, for bronchial asthma, for intolerance to drugs of the NSAID group, for cerebrovascular and other bleeding, for ulcerative colitis, inflammatory bowel disease, hemophilia, Crohn's disease, recurrent form of polyposis of the paranasal sinuses and nose, with active bleeding in the gastrointestinal tract, with a violation of blood coagulability.
The drug is not used in the progressive pathology of the renal system, with a pronounced form of renal failure, with hepatotoxic reactions against the background of Nimesulid in history, with active diseases of the hepatic system, with a decompensated form of chronic heart failure, with pregnancy, with hyperkalemia, children before reaching 12 years, with the simultaneous use of other hapatotoxic drugs, in the period after aortocoronary shunting.

Side effects

Use of the drug Nimesulid can cause a number of side effects.
Central nervous system: Reye's syndrome, headache, "nightmarish" dreams, fear, anxiety, dizziness, nervousness. Skin: increased sweating, itching, eruptions, dermatitis, erythema, angioedema, toxic epidermal necrolysis, multiform erythema exudative, urticaria, Stevens-Johnson syndrome.
Urinary system: interstitial nephritis, renal failure, hematuria, dysuria, urinary retention, oliguria. The digestive tract: cholestasis, gastritis, flatulence, constipation, increased liver enzymes, bleeding from the gastrointestinal tract, vomiting, nausea, diarrhea syndrome, jaundice, fulminant hepatitis, epigastric pain, perforation and ulcerative lesions of the stomach walls.
Organs of hematopoiesis: increased bleeding time, hemorrhage, purpura, pancytopenia, thrombocytopenia, anemia.
Respiratory system: bronchospasm, shortness of breath, possibly exacerbation of pre-existing bronchial asthma.
Organs of Senses: Visual impairment in the form of blurred vision.
Cardiovascular system: "tides" of blood flow to the skin of the face, drop in blood pressure, rapid heart rate. Also observed is hypothermia, general weakness, increased levels of potassium ions.

Instructions for use Nimesulid (Method and dosage)

The drug is taken twice a day for 50-100 mg, preferably after eating. With a pronounced pathology of the renal system, the daily dosage is 100 mg. It is recommended to use the drug as minimally as possible in minimal, but effective doses.
Instructions for use Nimesulid Maxpharma is similar.

Overdose

May be manifested by nausea, vomiting, increased drowsiness. There may also be signs of apathy, bleeding in the stomach and intestinal tract, increased blood pressure, respiratory depression.
Gastric lavage, the use of activated charcoal, treatment for symptoms are used.

Interaction

The risk of hepatotoxic exposure increases significantly with the simultaneous use of hepatotoxic medicines. The drug improves the effectiveness of anticoagulants. When taking furosemide, there is a decrease in the severity of its diuretic effect.
Nimesulid displaces salicylic acid, fenofibrate and furosemide from bonds with proteins. The drug raises the level of concentration of lithium ions in the blood plasma.
The drug can increase the toxicity of methotrexate, enhance the nephrotoxic effect of cyclosporine. The risk of gastrointestinal bleeding increases with simultaneous therapy with selective serotonin reuptake inhibitors, glucocorticosteroids.

Storage conditions

In a dark place inaccessible to children at a temperature of no more than 25 degrees Celsius.
Shelf life not more than 3 years.

special instructions

Patients in the period of treatment with Nimesulid are encouraged to monitor the liver system twice a month. With increasing levels of liver enzymes, the appearance of itching, rashes, pain in the epigastric region, jaundice, with darkening of urine treatment is discontinued. Reviews of the Nimesulid drug indicate a visual impairment in patients who have been taking the drug for a long time. When registering any changes on the part of the vision organs, the therapy is terminated and a compulsory complete ophthalmological examination is performed. The description of the medicine indicates a possible fluid retention in the body, which requires caution in the treatment of patients with essential hypertension. It is not recommended to prescribe Nimesulid together with other medicines from the NSAID group. The drug can not replace the preventive effect of antiaggregants, despite a marked decrease in the rate of platelet aggregation. The drug is not prescribed for women planning pregnancy due to a negative effect on fertility. Nimesulid may affect the management of motor vehicles.

Reviews of Nimesulid

The vast majority of reviews about Nimesulid are positive color. The medicine is very effective for relieving pain symptoms, temperature, various kinds of inflammation. The drug helps quickly and its effect is long-lasting.
In rare negative comments, there are references to the side effects of the medication.