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Heptor tabs user manual

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Composition

Tablets have in the INN composition S-adenosylmethionine (in terms of ademetionin). Also in its composition there are a number of additional substances: MCC, polyplasdone X-El-10 (crospovidone), magnesium stearate, mannitol.

Form of issue

The drug is available in the form of tablets, which covers the yellow membrane dissolving in the intestine. In the cross section, two layers are viewed. Tablets are packed in a blister for 10 pieces, 1 or 2 such blisters fit into the cardboard box. Also, the tablets are sold in cans of polymer or dark glass, in which 20, 40 or 50 tablets are packed.
Also, the preparation is released as a lyophilizate from which the solution is prepared. It is administered intravenously and intramuscularly. The medicine is contained in a vial that is packed in a cardboard box.

pharmachologic effect

Heptor is a hepatoprotective agent, which, moreover, has an antidepressant effect. On the body, this remedy has a regenerating, antioxidant, detoxifying, antifibrozing, neuroprotective effect.
Active component of the drug is ademethionine. This substance takes part in some biochemical processes in the human body, activates the production of endogenous ademetionine. This substance is in the tissues, as well as in the biological fluids of the body. It participates in biochemical reactions. Also, ademetionine is a precursor of polyamines, including putrescine, which stimulates cell renewal and proliferation of hepatocytes.

Pharmacodynamics and pharmacokinetics

The drug in the form of tablets covers the shell, which dissolves in the intestine, therefore, the active substance is released directly into the duodenum. After oral administration, bioavailability is 5%. The maximum concentration of the drug is observed in 2-6 hours after the patient takes it at a dose of 400 mg once.
The active substance is slightly bound to plasma proteins. In cerebrospinal fluid there is a high concentration of the drug. The active substance penetrates through the BBB.
Biotransformation of the agent occurs in the liver. It is excreted by the kidneys, the elimination half-life is 1.5 hours.

Indications for use of heptor

Indications for the use of the drug are as follows:
    treatment of patients with intrahepatic cholestasis;
    cirrhosis of the liver, precirototic conditions;
    treatment of hepatitis of various genesis, including toxic, medicinal, as well as viral hepatitis;
    encephalopathy of secondary origin;
    development of alcohol withdrawal syndrome;
    depressive syndrome.

Contraindications

The drug is not prescribed if the patient is intolerant of a certain component of the drug. Precautions are taken with treatment. The heptor of people diagnosed with cirrhosis of the liver is associated with hyperaemia. In this case, the treatment is carried out only under the condition of constant monitoring of the nitrogen content in the blood plasma.

Side effects

As a rule, the heptor is well tolerated. Only in some cases during treatment there is a feeling of discomfort in the epigastric region associated with the acidic pH of the active substance. As a rule, this side effect disappears on its own and does not require the withdrawal of treatment or additional therapy by other means. Allergic reactions can rarely develop.

Instructions for the use of the heptor (Method and dosage)

Before taking Heptor, the instructions for use should be carefully read. The drug is administered orally, the tablets should be swallowed whole, without chewing them and chopping them. Remove the tablet from the package immediately before use. Instructions for use Geptera provides that to obtain the maximum effect, it is desirable to take the heptor between meals.
How long the treatment should last, the doctor determines, taking into account the patient's condition. For maintenance treatment, adults are prescribed 2 to 4 tablets daily. They need to be taken in several receptions.
On average, the treatment lasts from 2 to 4 weeks. If there is such a need, a second course of treatment can be prescribed. Tablets and ampoules The heptor should not be used in the evening, as there may be a tonic effect of the remedy on the body.

Overdose

There is no evidence of an overdose of Heptor.

Interaction

There is no information on the manifestation of the drug drug interaction.

Storage conditions

Keep the tablets in their original packaging, protect them from direct sunlight. The temperature should be between 15 and 25 degrees.
Shelf life - 2 years.

special instructions

Due to the fact that the drug has a tonic effect, the remedy should not be used before bedtime.
If the course of treatment of this drug is prescribed to people suffering from cirrhosis of the liver against a background of hyperaemia, then it is necessary to ensure a clear control of the nitrogen content in the blood.
The special shell of tablets dissolves exclusively in the intestine, so the release of the active substance occurs after the tablet enters the duodenum.
In people suffering from bipolar affective disorder, in the treatment with ademetionine, an affect inversion can be induced.
In the treatment with Heptor, there is no evidence of an effect on a person's ability to drive transport and work with precise mechanisms.

Which is better: Heptor or Heptral?

Both Heptor and Heptral have a similar active ingredient - ademethionine. Therefore, their effect on the metabolism in the cells of the liver and human brain is practically the same. Heptral is realized in the form of tablets, as well as injections for intravenous and intramuscular injection. The main differences - the manufacturer and the cost of these drugs. Heptor - a preparation of domestic production. Heptral produced in Italy, respectively, its cost is higher.

Children

It is not used for therapy of children and adolescents under 18 years of age.

In pregnancy and lactation

In the first two trimester of pregnancy, you can not use heptor. In the third trimester, the remedy can be prescribed only if the decision is made by the attending physician. It is important to monitor the health of the mother and fetus regularly and very clearly. In the months of feeding, a woman can practice Heptorum treatment only after the appointment of a doctor, who decides whether to continue breastfeeding.

Reviews about Heptor

Visiting a specialized forum or site, you can find numerous reviews about Heptor. Patients note as an advantage the relatively low cost of the drug, as well as the convenience of its use. The doctors' comments indicate a positive effect after the course of treatment with the drug. Improvement of the condition is noted already in the process of treatment, but it is necessary to adhere to the treatment scheme that was prescribed by the doctor.