Differin gel 0.1% 30gr

You can buy Differin gel online

Differin gel instruction for use

Composition of Differin

Gel Differin for external use contains the following components:
    adapalene - 1 mg per 1 g of a pharmaceutical preparation;
    propylene glycol;
    methylparahydroxybenzoate;
    phenoxyethanol;
    carbomer 940 P;
    disodium edetate;
    poloxamer 182;
    sodium hydroxide;
    purified water.

Form of issue

In pharmacy kiosks and cosmetics stores for personal hygiene, the pharmaceutical product is presented in two forms:
    Gel for external use in white in plastic tubes of 30 g. The cardboard box contains 1 tube and instructions for use.
    Cream for external use in aluminum tubes for 30 g. In the cardboard box is attached annotation and 1 tube with medicinal ointment.

pharmachologic effect

Cream Differin and gel, as a variation of a single medicine, belong to the group of anti-inflammatory and comedonolytic agents that are used externally. The therapeutic effect develops due to the main active ingredient called adapalene, which is a retinoid metabolite. The biologically active substance normalizes the processes of keratinization and epidermal differentiation at the cellular level.
Gel against black spots Differin has a selective mechanism for the development of beneficial effects, which consists in the interaction of the active component with specific receptors of the epidermal cells of the skin, resulting in the weakening of cellular bonds in the mouths of the sebaceous hair follicles and the elimination of etiological factors for microcosmodes.
Along with the above mechanism of action, it should not be forgotten that Adapalene has strong anti-inflammatory properties, since a component of a pharmaceutical drug inhibits the migration of white blood cells to the focus of inflammation and metabolism of arachidonic acid, which "turns off" the leukocyte from the pathological process.

Pharmacodynamics and pharmacokinetics

Both forms of the drug are intended for topical application to the skin and effects on epidermal skin cells, so the absorption of the active ingredients from the surface of the treated area is very low. Excretion of the absorbed part of biologically active substances occurs mainly through bile.

Indications for use

    acne or acne;
    Acne vulgaris;
    black dots;
    comedones.

Contraindications

    increased sensitivity to the acting and auxiliary components of the pharmaceutical preparation;
    hereditary or acquired intolerance of the drug and its constituent elements;
    dermatitis;
    eczema;
    neoplasm of the skin;
    childhood;
    period of pregnancy and breastfeeding;
    damage to the skin;
    burn wound surface;
    use of systemic drugs from the retinoid group.

Side effects

In the process of conservative treatment with a pharmaceutical agent, development is possible:
    irritation of the skin at the treatment site;
    redness and flaky skin;
    sensation of itching or burning;
    dry skin;
    local change in physiological pigmentation;
    contact dermatitis;
    eczema;
    allergic conjunctivitis.
If these side effects are observed, it is strongly recommended to immediately stop further sanation and consult a qualified dermatologist. It should also be noted that the drug increases the risk of sunburn at a normal level of solar radiation.

Instructions for Differin (Method and Dosage)

Gel Differin, instructions for use

Before applying the gel from acne, it is necessary to cleanse the face, so the therapeutic possibilities of the pharmaceutical preparation will be much higher. However, do not use alcohol or soap solutions for this, it is recommended to apply a gel for washing. The ointment is applied evenly thin layer on the whole face (if Differin is used from black dots) or selectively only for inflammatory elements for their elimination, do not rub.
Multiplicity of application - once a day, use the drug better in the evening, before going to bed, as at night the reparative mechanisms of the skin are higher due to the activity of the parasympathetic nervous system. The maximum effect from the use of the gel is observed, usually in a month, but the full course of conservative therapy of getting rid of black spots or acne lasts 3 months. The possibility of re-sanitation with a pharmaceutical preparation should be discussed with a dermatologist in addition.

Overdose

The state of intoxication by the acting or auxiliary components is unlikely, since Differin has a low absorption capacity (only 4% of the applied amount of ointment or gel is absorbed into the microcirculatory bed). In case of accidental oral administration or application of the drug to damaged skin, prolonged uncontrolled use, it is possible to develop the following symptoms:
    dry skin;
    muscle pain;
    lacrimation;
    symptoms of vitamin A poisoning in especially severe cases.

Terms of sale

In pharmacy kiosks and beauty salons-stores the drug is dispensed without a prescription.

Storage conditions

Adapalene, the main active ingredient of the Differin cosmetic, is resistant to light, oxygen and is not chemically active, therefore it is easy to store the drug. Both the gel and cream should be stored at a temperature of 25 degrees Celsius in a place inaccessible to children.

Shelf life

2 years at a cream for external application and 3 years at 0,1% of a gel.

special instructions

After the appointment of a pharmaceutical drug, most patients are wondering what is better - cream or Differin gel. Both forms of the drug contain the active active ingredient in an equal amount, and therefore the therapeutic properties do not differ. What about the auxiliary active substances - based on their combination, it can be argued that the cream is usually shown in more sensitive and dry skin, since biological components can improve the trophic to some extent, but their beneficial effects develop gradually due to the specificity of the chemical interactions .

In pregnancy and lactation

Contraindicated for use in the period of breastfeeding or pregnancy due to the possible development of a vitamin A overdose and subsequent adverse effects on the child.

Reviews about Differin Gel

Pharmaceutical preparation belongs to imported cosmetic products, which have high therapeutic efficacy, therefore undoubtedly reviews about Differin from acne are overwhelmingly positive. The active ingredient allows not only to clean the skin of the face, back, shoulders and chest from unpleasant or at times disfiguring rashes, but also contributes to the normalization of trophic and plastic properties of the surrounding tissue, which can not be ignored as an aspect of a pharmaceutical product for acne.
Reviews about gel Differin from qualified dermatologists only confirm good recommendations and opinion of people who used a gel or cream. Adapalene, the main active component, carefully regulates the processes of keratinization and differentiation of epidermal cellular structures at the biochemical level, which is confirmed in the course of repeated clinical studies.
Of course, reviews of the Differin gel are often overshadowed by the high cost of the drug, since it is made from the best constituent components and is an imported cosmetic drug. However, such a price is fully justified, after all, after a full course of conservative sanitation at 3 months, biologically active components allow achieving a stable remission for many years.