Heparin-Akrihin gel 1000ME/gr 50gr

Heparin-Akrihin user manual

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Composition

100 g of Heparin-Akrihin gel contain:
Active substance: heparin sodium in terms of dry matter - 0.83 g (100000 ME);
auxiliary substances: methyl parahydroxybenzoate 0.15 g, carbomer 940 1.25 g, trometamol 0.85 g, ethanol 96% (rectified ethyl alcohol) 24 g, lavender oil 0.02 g, orange flowers oil (neroli oil) 0.01 g, purified water up to 100 g.

Description of Heparin-Akrihin

Transparent or almost transparent, colorless or slightly yellowish shade gel with a specific odor.

Pharmacotherapeutic group

anticoagulant direct action for topical application
CODAC: C05BA03

Pharmacological properties

Pharmacodynamics

Direct anticoagulant, has anti-inflammatory, antiproliferative, anti-edematous and analgesic effect. Reduces platelet aggregation, binds to antithrombin III, preventing the transition of prothrombin to thrombin. Oppresses the activity of thrombin. Reduces the activity of hyaluronidase, increases the fibrinolytic properties of the blood. It improves microcirculation and activates tissue metabolism, thereby accelerating the processes of resorption of hematomas and thrombi, eventually restoring the permeability of veins, clinically it is accompanied by a pronounced analgesic and anti-inflammatory effect.

Pharmacokinetics

An insignificant amount of heparin is absorbed from the surface of the skin into the systemic circulation. The maximum concentration of the active substance in the blood is noted 8 hours after the application. The elimination of heparin, mainly occurs through the kidneys, half-life of 12 hours.

Indications for use

Thrombophlebitis of superficial veins; localized infiltrates and swelling of soft tissues; trauma of tendons and joints, bruises of soft tissues and joints.

Contraindications

Hypersensitivity to any of the components of the drug, ulcerative necrotic changes in the skin at places of supposed application of the gel, traumatic violation of the integrity of the skin, reduced blood clotting, thrombocytopenia.

Application in pregnancy and lactation

The drug is not contraindicated for use in pregnancy and lactation.

Dosing and Administration

Outwardly. The gel is applied a thin layer on the affected area at a rate of 3-5 cm gel per skin area 3-5 cm in diameter and gently rubbed into the skin.
Apply 1 -3 times a day daily until the disappearance of inflammatory phenomena, an average of 3 to 7 days. The timing of treatment is determined by the doctor.

Side effects

Skin allergic reactions, skin hyperemia.

Overdose

Overdose is unlikely due to low absorption of the components of the gel. It shows bleeding. It is removed by protamine sulfate (a chemical antagonist).

Interaction Heparin-Akrihin with other drugs

It is not recommended to mix with other products for external use.
Do not prescribe topically at the same time with non-steroidal anti-inflammatory drugs, tetracyclines, antihistamines.
The combined use of a gel with oral anticoagulants can cause prolonged prothrombin time.

special instructions

It is not recommended for bleeding, as well as for open wounds, mucous membranes and in the presence of local purulent processes.
Use Heparin-Akrihin with extreme caution with increased vascular permeability.
The use of the gel is not recommended for deep venous thrombosis.

Form of issue

Gel for external use 1000 IU / g.
For 30 or 50 g in an aluminum tube. Each tube together with instructions for use in a pack of cardboard.

Storage conditions

At a temperature of 15 to 25 ° C. Keep out of the reach of children,
Shelf life - 2 years. Do not use after the expiration date.

Conditions of leave from pharmacies

To buy Heparin-Akrihin gel the prescription is not required.