Acyclovir cream 5% 2gr
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Acyclovir cream instruction for useYou can buy Acyclovir cream hereForm of release, composition and packagingCream for external use 5% white or almost white, homogeneous.100 gAcyclovir 5 gAuxiliary substances: macrogol and fatty a..
Acyclovir cream instruction for use
You can buy Acyclovir cream here
Form of release, composition and packaging
Cream for external use 5% white or almost white, homogeneous.
Acyclovir 5 g
Auxiliary substances: macrogol and fatty acid ester (arlaton 983S) - 5 g, dimethicone 350 - 0.3 g, cetyl alcohol - 1.5 g, white petrolatum - 9 g, paraffin liquid - 5 g, propylene glycol - 15 g, purified water - 59.2 g .
Antiviral drug for external use. Acyclovir is active against Herpes simplex types 1 and 2, the virus Varicella zoster, the Epstein-Barr virus and cytomegaloviruses. Thymidine kinase virus-infected cells through a series of consecutive reactions actively converts acyclovir into mono-, di- and triphosphate acyclovir. The latter interacts with the viral DNA polymerase and is embedded in DNA, which is synthesized for new viruses. Thus, "defective" viral DNA is formed, which leads to suppression of replication of new generations of viruses.
With topical use, it is almost not absorbed through intact skin, it is not detected in blood and urine. When applied to the affected skin, the absorption is moderate.
It is excreted by the kidneys (up to 9.4% of the daily dose). In patients with normal renal function, the concentration of acyclovir in serum is up to 0.28 μg / ml.
Pharmacokinetics in special clinical cases
In patients with chronic renal failure, the concentration of acyclovir in the blood serum is up to 0.78 μg / ml.
- skin infections caused by the Herpes simplex virus types 1 and 2, including genital herpes and herpes lips;
- hypersensitivity to acyclovir and other components of Acyclovir cream;
With caution should prescribe Acyclovir cream during pregnancy, during lactation, dehydration, kidney failure.
Outwardly. The drug is applied 5 times / day (every 4 hours) in a thin layer on the affected and adjacent areas of the skin. The cream is applied either with a cotton swab or with clean hands to avoid additional infection of the affected areas. Therapy should be continued until the time when no bubbles form on the vesicles, or until they completely heal. The duration of therapy is an average of 5 days and should not exceed 10 days.
Side effects of Acyclovir cream
Local reactions: hyperemia, dryness, scaling of the skin; burning, inflammation in contact with mucous membranes.
Possible the development of allergic dermatitis.
Data on an overdose of Acyclovir Hexal is not available.
With external application, no interaction with other drugs has been identified.
An increase in the effect is noted with the simultaneous appointment of immunostimulants.
To achieve maximum therapeutic effect, it is necessary to start using Acyclovir cream as soon as possible after the onset of infection (at the first signs of the disease - burning, itching, tingling, sensation of tension and redness).
The cream is not recommended to be applied to the mucous membranes of the mouth and eyes. possible development of pronounced local inflammation.
In the treatment of genital herpes, sexual intercourse should be avoided or condoms should be used. the use of acyclovir does not prevent the transmission of the virus to partners.
Pregnancy and lactemia
Caution should be given to Acyclovir cream during pregnancy and lactation (breastfeeding).
Adequate and controlled clinical studies of safety of Acyclovir cream during pregnancy were not conducted. The application is indicated only in cases where the intended use for the mother exceeds the potential risk to the fetus.
During the treatment period, it is necessary to resolve the issue of stopping breastfeeding.
In case of violations of kidney function
With caution should prescribe Acyclovir cream for kidney failure.
Conditions of leave from pharmacies
You can buy cream Acyclovir without a prescription.
Terms and conditions of storage
Acyclovir cream should be stored out of the reach of children at a temperature of no higher than 25 ° C. Shelf life - 4 years.