Artra MSM Forte tabs #60

Artra MSM Forte user manual

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Form of release, composition and packaging

The tablets covered with a film membrane from light yellow-orange to dark orange color, oval, biconcave; a specific smell is allowed.

pharmachologic effect

The components of the drug have the ability to inhibit the progression of osteoarthritis. Suppresses destruction and stimulates the regeneration of cartilaginous tissue. The drug has anti-inflammatory and analgesic effect. Improves blood flow in the subchondral bone. Reduces the need for NSAIDs.
Glucosamine and chondroitin sulfate are involved in the synthesis of connective tissue.
The introduction of exogenous glucosamine enhances the production of the cartilage matrix and provides non-specific protection against chemical damage to the cartilage.
Chondroitin sodium sulfate serves as an additional substrate for the formation of a healthy cartilage matrix. Stimulates the formation of hyaluronan, the synthesis of proteoglycans and collagen type II, and also protects hyaluronan from enzymatic cleavage (by suppressing the activity of hyaluronidase) and the damaging effect of free radicals; maintains the viscosity of the synovial fluid.
Hyaluronic acid is a polysaccharide group of acidic glycosaminoglycans, an important component of the synovial fluid, determining its viscoelastic properties. It forms on the entire inner surface of the covering layer, which protects articular cartilage and synovial membrane from mechanical damage, as well as free radicals and inflammation factors.
Methylsulfonylmethane (MSM) is an organic sulfur-containing compound. It is a key metabolite of dimethylsulfoxide (DMSO). Contains 34% of natural sulfur. MSM is a part of many endogenous proteins (including connective tissue proteins - collagen, elastin, keratin), hormones and other metabolically active compounds. MSM has an anti-inflammatory and analgesic effect.

Pharmacokinetics

Suction

Bioavailability of glucosamine with oral administration is 25% (the effect of "first passage" through the liver).
Concentration in the plasma of chondroitin sulfate: once taken at a dose of 0.8 g (or twice a day at a dose of 0.4 g) sharply increases for 24 hours. Absolute bioavailability is 12%. About 10% and 20% of the accepted dose is absorbed in the form of high-molecular and low-molecular derivatives, respectively.
In the experimental models, a certain bioavailability of hyaluronic acid is shown when administered orally.

Distribution

Chondroitin sulfate is distributed in tissues: the highest concentrations are found in the liver, kidneys and articular cartilage. About 30% of the dose is persistently persistent in bone and muscle tissue.

Metabolism and excretion

Glucosamine is excreted mainly by the kidneys in an unchanged form; partially through the intestine.
Chondroitin sulfate is metabolized by desulfurization. It is excreted in the urine. T1 / 2 - 310 min.

Indications of Artra MSM Forte

- osteoarthrosis of peripheral joints;
- osteocondritis of the spine.

Dosing regimen

Inside. Adults and children 15 years and older 1 tablet 2 times / day for the first three weeks; 1 tablet 1 time / day for the following weeks and months. The course of treatment is not less than 3 months

Side effect

Possible: allergic reactions; pain in epigastrium, flatulence, diarrhea, constipation, nausea, vomiting.

Contraindications for use

- hypersensitivity to the components of the drug;
- Pregnancy;
- lactation period;
- Children under 15 years.
With caution: a violation of blood clotting, diabetes mellitus, bronchial asthma, intolerance to seafood (shrimp, shellfish).

Application in pregnancy and lactation

Contraindicated in pregnancy and lactation.

Use in children

Contraindicated for children under 15 years.

special instructions

It is not recommended for children under 15 years of age due to a lack of scientific data for this category of patients.
Adults with chronic diseases should consult a doctor before taking the drug.
Impact on the ability to drive vehicles and mechanisms
Does not affect the driving of cars and the management of other mechanisms.

Overdose

Cases of overdose are not known.
Symptoms: in case of taking large amounts of the drug (more than 10 capsules), nausea, vomiting, diarrhea, hemorrhagic eruptions may occur.
Treatment is symptomatic: gastric lavage.

Artra MSM Forte Interactions

Increases the absorption of tetracyclines, reduces the effect of semisynthetic penicillins.
The drug is compatible with NSAIDs and GCS.
It is possible to increase the effect of indirect anticoagulants, antiaggregants, fibrinolytics.

Terms and conditions of storage

The drug should be stored out of reach of children, dry place, at a temperature of 10 ° to 30 ° C. Shelf life - 3 years. Do not use after the expiration date.

Conditions of leave from pharmacies

The drug is dispensed without a prescription.