Artra tabs #120

Artra instruction

You can buy Artra tablets online

Composition

Concentration of active substances in one tablet Artra:
    chondroitin (500 mg;
    glucosamine (500 mg).
As auxiliary components in the preparation include: sodium croscarmellose, MCC, stearic acid, disubstituted calcium phosphate, magnesium stearate.
Film membrane: triacetin, hydroxypropylmethylcellulose (stabilizer E464), titanium dioxide (E171 additive).

Form of issue

Tablets in p / o. Tablets are packaged in 30, 60, 100 or 120 pieces in white bottles of dense polyethylene with a screw cap, under which a safety valve made of foil is provided. Each vial is wrapped with PE film and, together with the instruction, is placed in a pack of cardboard.

pharmachologic effect

The action of the drug is aimed at correction of metabolic processes in cartilage and bone tissue.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug is a stimulant of the regenerative processes in the cartilaginous tissue. Its active components are involved in the synthesis of connective tissue, preventing the destruction of cartilage and stimulating the regeneration of its tissues.
The introduction of exogenous glucosamine helps to increase the production of cartilage matrix (intercellular substance) and provides non-specific protection of cartilage from chemical damage.
Contained in tablets in the form of a sulfate salt, glucosamine is a precursor of hexosamine, and the sulfate anion is necessary for the production of mucopolysaccharides (glycosaminoglycans) of connective tissue.
Another putative function of glucosamine is the protection of damaged cartilage tissue from metabolic destruction caused by the use of GCS / NSAIDs and its own anti-inflammatory effect (the latter is moderately pronounced).
Chondroitin, no matter in what form it is absorbed (in intact or in the form of separate components), serves as an additional substrate for the formation of a healthy matrix of cartilage.
In addition, the substance:
    stimulates the synthesis of hyaluronan, collagen type II and proteoglycans;
    suppressing the activity of free radicals, provides protection of hyaluronan from cleavage under the influence of enzymes and aggressive action of free radicals;
    stimulates mechanisms of repair of cartilaginous tissue;
    inhibits the activity of cartilage-splitting enzymes (hyaluronidase and elastase);
    maintains the necessary viscosity of synovia.
In patients suffering from osteoarthritis, it alleviates the symptoms of the disease and reduces the need for NSAIDs.

Pharmacokinetics

Bioavailability of glucosamine when ingested - 25% (the effect of the first passage through the liver). In the body, the greatest concentration is found in cartilage of joints, kidneys and liver.
Approximately one third of the dose taken remains in the muscles and bone tissue for a long time. Most of the substance is excreted unchanged in kidneys, the remainder - with feces. Semi-elimination period is 68 hours.
After ingestion of 800 mg of chondroitin sulfate (for 1 or 2 administration), the plasma concentration of the substance sharply increases throughout the day. The absolute bioavailability index is 12%.
Approximately a tenth of the dose is absorbed in the form of high molecular weight derivatives, about 20% in the form of low molecular weight derivatives.
Metabolized mainly by desulfurization. It is excreted from the body by the kidneys. The half-elimination period is 5 hours and 10 minutes.

Indications for use

Artra tablets are prescribed for osteoarthritis of the spine and peripheral joints of I-III degree.

Contraindications

Medication Artra is contraindicated in case of intolerance to any of the substances included in the tablets, expressed renal dysfunction, phenylketonuria.
Feedback on contraindications to the Artra tablets is confirmed by the fact that the drug should be used with caution in patients prone to bleeding, bleeding, diabetes, bronchial asthma.

Side effects

Against the backdrop of the use of glucosamine, such functional disorders of the gastrointestinal tract as bloating (bloating), constipation / diarrhea, pain in the epigastric region are often recorded. Also possible:
    dizziness;
    drowsiness / insomnia;
    headache;
    cutaneous manifestations of allergy;
    peripheral edema;
    pain in the legs;
    tachycardia.
Reception of chondroitin can provoke hypersensitivity reactions.

Medication Artra, instructions for use

The instructions for the use of Artra indicate that in the first three weeks of treatment, the tablet should be taken twice a day, one at a time. In the following weeks and months, the frequency of applications is reduced to once a day.
The drug is designed to treat patients older than 15 years. The therapeutic effects and absorption of active ingredients do not depend on the time of day and food intake.
To achieve a sustainable therapeutic effect, it takes at least six months.
As an addition to the main therapy to improve the functional state of the musculoskeletal system, the capsules Artro-Active can be used as an additive to food. Daily dose of dietary supplements - 4-6 capsules 300 mg.
Treatment is carried out by courses lasting from two weeks to one month. The optimal interval between courses is two weeks.

Overdose

Information on cases of drug overdose is not present.
Treatment: symptomatic.

Interaction

Artra tablets can enhance the effect of antiaggregants and anticoagulants, increase the absorption of tetracyclines, reduce the effect of semisynthetic penicillins.
Compatible with non-steroidal anti-inflammatory and GCS-drugs.

Terms of sale

Without prescription.

Storage conditions

Tablets Artra should be stored at a temperature of 10 to 30 ° C in a place protected from moisture, inaccessible to children.
Shelf life - Five years.

special instructions

In case of development of undesirable reactions from the digestive system, it is recommended to reduce the dose, and in the absence of improvements - to stop taking the drug.

Analogues of Artra

The trade name of the drug with the same active ingredient: Theraflex.
An analogue with a similar mechanism of action: Traumeel C.

Which is better: Artra or Dona?

The composition of the drug Dona contains only one active substance - glucosamine (in the form of sulfate), whereas in tablets of Artra the action of glucosamine hydrochloride is enhanced by chondroitin sodium sulfate.
Nevertheless, the results of studies performed in the group of patients with osteoarthritis of large joints indicate that glucosamine sulfate is the only drug with proven structural and modifying properties in this pathology.
The advantage of Dona can be considered more dosage forms. The preparation is available in the form of a powder for the preparation of an oral suspension, an injection solution and tablets.

Which is better: Artra or Theraflex?

The drug Theraflex is available in capsules based on D-glucosamine hydrochloride (500 mg / caps.) And chondroitin sodium sulfate (400 mg / caps.).
Having a composition almost identical with Artra, Theraflex, accordingly, has approximately the same efficiency as it.

Artra or Structum - which is better?

Structum is a hard capsule, each containing 500 mg of chondroitin sodium sulfate.
The drug has an effect similar to that of Artra, but the latter, in view of the fact that it contains simultaneously two active components that enhance the effect of each other, can be considered more effective.

For children

In pediatrics it is used from the age of fifteen.

In pregnancy

During pregnancy and breastfeeding, the Artra joint preparation is not recommended.

Reviews of Artra

The patients' comments about the Artra drug are contradictory - someone says that after three months of regular use they felt a significant improvement, someone faced unpleasant side effects or did not see the results of the treatment at all.
The peculiarity of the preparation is that the active substances contained in it are natural structural components of intraarticular fluid and cartilage tissue. The effect of its application is associated with the replacement of the deficiency of these compounds in the body.
In addition, being very physiological for the body, the drug does not affect the pharmacokinetics and effectiveness of other agents (except semisynthetic penicillins and tetracyclines), and it can be taken at any convenient time.
Unlike most analogues, Artra is registered not as a dietary supplement, but as a medicinal product. This is very important, as the requirements for clinical studies of the effectiveness of drugs and their quality are higher than the requirements for conducting studies on efficacy and safety, as well as the quality of the supplements.
A high concentration of active substances in each pill allows you to take the drug 1-2 times a day. At the same time, Artra is perfectly safe even with prolonged use: its safety has been proven in clinical trials (including patients with concomitant pathologies and when used in combination with other drugs).
An important aspect of drug treatment is also the possibility to reduce the dose of concurrent NSAIDs (which, as is known, have a lot of side effects) or completely refuse to take them.
If we talk about the opinion of specialists, then the doctors' reviews of chondroprotectors generally allow us to conclude that the use of drugs of this group did not receive high indicators of evidence in studies on the principles of evidence-based medicine, and therefore their application is not a curative process, but may refer to supporting techniques .