Piascledine 300 caps 300mg #30

Piascledine 300 user manual

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Composition

One capsule contains 100 mg of avocado oil of unsaponifiable compounds and 200 mg of soy bean oil unsaponifiable compounds.
Auxiliary components: butylhydroxytoluene, polysorbate, colloidal silicon dioxide. The capsule contains titanium dioxide (E171) and gelatin.

Form of issue

It is produced in blisters with 15 capsules having a white cap and an opaque white case marked "P 300". Capsules contain a brown paste. There is one or two blisters in the cardboard bundle.

pharmachologic effect

Anti-inflammatory, antirheumatic and corrective action of cartilage tissue metabolism.

Pharmacodynamics and pharmacokinetics

The medicine of plant origin is able to regulate metabolic processes in the cartilaginous tissue, has an anti-inflammatory and analgesic effect on the joints. Slowing down the degenerative processes in the cartilaginous tissue, reduces pain and restores motor function. The regenerative effect on cartilage is due to the stimulation of collagen synthesis in joint chondrocytes.
Functions of unsaponifiable oil compounds of soy and avocado beans:
    Increasing the production of collagen and inhibiting the stimulating effect of interleukin-1 on the secretion of the enzyme collagenase.
    Increasing the production of the plasminogen activator inhibitor reduces the damage to the cartilage indirectly by stimulating metalloproteinase, by direct action on the cartilage, by activating the degradation of proteoglycans.
    Strengthening of the transforming factor TGF growth of β1 in cells - chondrocytes, which has anabolic properties.
    Stimulation of synthetic processes of macromolecules of hyaline cartilage, periodontal tissue, prevents the loss of teeth.

Indications for use

    In rheumatology: as a component of the complex therapy for osteoarthrosis of knee and hip joints of the 1st - 3rd stage.
    In dentistry: maintenance therapy of periodontitis.

Contraindications

    Hypersensitivity to the components of this drug;
    The drug is contraindicated during pregnancy and lactation, as well as children under 18 years.

Side effects

It is possible to develop various allergic reactions, and very rarely - an increase in laboratory parameters such as hepatic transaminase activity, alkaline phosphatase, γ-glutamyltransferase and bilirubin level.

Piascledine, instructions for use (Method and dosage)

One capsule inside (with a glass of water) once a day, preferably in the morning during a meal.
Instructions for use Piascledine 300 assumes a standard 6-month course of treatment, which can be increased and repeated again strictly on the recommendation of the attending physician or therapist.

Overdose

At the moment there are no cases of drug overdose.

Storage conditions

In a place inaccessible to minors. Without the possibility of penetration of light rays, as well as at a temperature of 15-25 ° Celsius.
Shelf life not more than three years.

Reviews of Piascledine 300

Reviews about Piascledine are in most cases positive, patients talk about the successful use of the drug for osteoarthritis and periodontitis, however, many emphasize that the shifts were insignificant.
The remedy is considered quite new - appeared on the Russian pharmaceutical market in 2008, but in recent years it has found its field of application and received positive reviews from doctors about Piascledine 300 as an antirheumatic drug.