Erispirus syrup 2mg/ml 150ml
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Erispirus syrup user manualYou can buy Erispirus syrup hereComposition1 ml of syrup contains: active ingredient: fenspiride hydrochloride - 2.00 mg;auxiliary substances: sucrose - 600.00 mg; glycerin - 225.00 mg; dye sunset sunset..
Erispirus syrup user manual
You can buy Erispirus syrup here
1 ml of syrup contains: active ingredient: fenspiride hydrochloride - 2.00 mg;
auxiliary substances: sucrose - 600.00 mg; glycerin - 225.00 mg; dye sunset sunset yellow (E110) - 0.10 mg; potassium sorbate - 1.90 mg; sodium saccharinate - 0.45 mg; flavoring cherry - 1,20 mg; citric acid monohydrate 1 - q.s .; sodium hydroxide 1-q.s .; water - up to 1 ml.
1 - to bring the pH to the desired value (pH = 5.0).
Description: transparent liquid of orange-red color with a cherry smell.
anti-inflammatory anti-bronchoconstrictive agent.
ATX code: R03DX03.
Pharmacological properties of Erispirus syrup
Anti-inflammatory and anti-bronchoconstrictive activity of fenspiride is caused by a decrease in the production of a number of biologically active substances (cytokines, especially tumor necrosis factor α (TNF-α), arachidonic acid derivatives, free radicals) that play an important role in the development of inflammation and bronchospasm.
Inhibition of fenspiride metabolism of arachidonic acid is potentiated by its H1-antihistamine action, t. histamine stimulates the metabolism of arachidonic acid with the formation of prostaglandins and leukotrienes. Fenspiride blocks α-adrenoreceptors, stimulation of which is accompanied by an increase in the secretion of bronchial glands.
Thus, fenspiride reduces the effect of a number of factors that contribute to the hypersecretion of pro-inflammatory factors, the development of inflammation and bronchial obstruction.
Fenspiride also has an antispasmodic effect.
After oral administration, the maximum concentration (C max) in blood plasma is achieved after 2.3 ± 2.5 hours (0.5 to 8 hours).
It is excreted mainly by the kidneys, the elimination half-life (T1 / 2) is 12 hours.
Indications for use
Diseases of the upper and lower respiratory tract:
• Rhinopharyngitis and laryngitis;
• bronchitis (on the background of chronic respiratory failure or without it);
• bronchial asthma (as part of complex therapy);
• respiratory symptoms (cough, hoarseness, throat swelling) with measles, pertussis, influenza;
• Infectious respiratory diseases accompanied by coughing, when standard antibiotic therapy is indicated;
• sinusitis and otitis of various etiologies.
Contraindications for Erispirus syrup
• hypersensitivity to fenspiride and other components of Erispirus syrup;
• Lactation period;
• deficiency of sugar / isomaltase, intolerance to fructose, glucose-galactose malabsorption;
• Children under 2 years.
With caution: diabetes, simultaneous reception of sedatives.
Application in pregnancy and during breastfeeding
Taking Erispirus syrup during pregnancy is not recommended.
Therapy with fenspiride is not a reason for interrupting the pregnancy that has occurred.
Clinical data on the fetotoxic effect of fenspiride or its ability to cause malformations during admission during pregnancy are absent.
It is not known whether fenspiride penetrates into breast milk. If it is necessary to use Erispirus syrup during lactation, it is necessary to resolve the issue of stopping breastfeeding.
Dosing and Administration
Follow strictly the doctor's recommendation.
Inside, before eating. Shake before use.
For convenience of dosing, you should use a measuring spoon (included in the kit) with a volume of 5 ml.
Adults: 9-18 measuring spoons of syrup per day (45-90 ml).
Children from 2 to 16 years:
• Body weight more than 10 kg: 6-12 measuring spoons of syrup per day (30-60 ml);
• Body weight less than 10 kg: 2-4 measuring spoons of syrup per day (10-20 ml).
The daily dose of the drug can be divided into 3 doses.
Can be added to the bottle with food.
The duration of therapy is determined by the doctor.
Side effects of Erispirus syrup
According to the World Health Organization (WHO), adverse reactions are classified according to their frequency of development as follows: very often (> 1/10), often (> 1/100, <1/10), infrequently (> 1/1000, < 1/100), rarely (> 1/10000, <1/1000) and very rarely (<1/10000); frequency is unknown - according to available data, it was not possible to establish the frequency of occurrence.
From the central nervous system
frequency unknown: dizziness.
From the side of the cardiovascular system
rarely: moderate sinus tachycardia, the severity of which decreases with a decrease in the dose of Erispirus syrup;
frequency unknown: sensation of heartbeat, hypotension, possibly associated with tachycardia.
From the gastrointestinal tract
often: gastrointestinal disorders, nausea, pain in the epigastric region;
frequency unknown: diarrhea, vomiting.
From the skin and subcutaneous tissues
rarely: erythema, rash, hives, angioedema, fixed erythema pigmentosa;
frequency is unknown: itching, toxic epidermal necrolysis, Stevens-Johnson syndrome.
frequency unknown: asthenia, increased fatigue.
If the drug is overdosed (there have been cases of overdose when taking Erispirus syrup at a dose of more than 2320 mg), you should immediately seek medical help.
Symptoms: drowsiness or agitation, nausea, vomiting, sinus tachycardia.
Treatment: symptomatic therapy, gastric lavage, electrocardiogram monitoring (ECG). Maintaining important body functions.
Interaction Erispirus syrup with other drugs
Because of the possible sedative effect when taking blockers of histamine H1 receptors, the use of Erispirus syrup in combination with drugs with a sedative effect is not recommended.
It is not recommended simultaneous use of Erispirus syrup with alcohol.
In the event of an infection of the respiratory system caused by bacteria or fungi, fenspiride is recommended to be prescribed only in combination with antibacterial and antifungal therapy.
The drug does not contain parabens.
Indication for patients with diabetes: 1 measuring spoon syrup (5 ml) contains 0.3 XE.
Special precautions for the destruction of unused medicinal product
There is no need for special precautions when destroying an unused preparation of Erispirus syrup.
Influence on ability to drive vehicles, mechanisms
Studies to study the effect of Erispirus syrup on the ability to drive vehicles and work with mechanisms have not been carried out. Patients should be aware of the possible development of drowsiness when taking the drug, especially at the beginning of therapy or in combination with the intake of alcohol. Care must be taken when working with vehicles, mechanisms.
Form of issue
Syrup, 2 mg / ml
To 150 ml of syrup in the bottles of yellow glass, sealed with screw caps with a protective ring.
For 1 bottle complete with a dosage plastic spoon in a pack of cardboard along with instructions for use.
In the dark place at a temperature of no higher than 25 ºС.
Keep out of the reach of children.
Shelf life - 2 years.
Do not use the product after the expiry date printed on the package.
You don't need a prescription to buy Erispirus syrup.