Relpax tabs 40mg #2

Relpax instruction for use

You can buy Relpax tablets on this page

Composition

The composition of the Relpax tablets contains the active component eletriptan (in the form of hydrobromide).
And also additional components: lactose monohydrate, MCC, magnesium stearate, croscarmellose sodium.

Form of issue

The product is released in the form of tablets of 20 and 40 mg, which are packed in foil blisters, placed in cardboard packs.
    Tablets, 20 mg orange, biconvex, round shape. They are covered by a film shell, on one side of the tablet there is an engraving "REP 20", on the other - "Pfizer".
    Tablets, 40 mg orange, biconvex, round shape. They are covered by a film shell, on one side of the tablet there is an engraving "REP 40", on the other - "Pfizer".

pharmachologic effect

Relpax - a drug with antimigrenous action. The active ingredient eletriptan demonstrates pronounced selectivity relative to serotonin receptors, which are located in the carotid arteries.
The antimigraine activity of the drug is related to the ability of eletriptan to narrow the blood vessels inside the skull and its inhibitory effect on neurogenic inflammation.

Pharmacokinetics and pharmacodynamics

After oral administration, eletriptan is actively absorbed in the digestive tract, absorption is 81%. The bioavailability level for internal admission is approximately 50%.
The highest concentration in the blood is observed 1.5 hours after internal administration. The maximum concentration of active substance increased by 20-30% if the medicine was taken after a fat meal. With blood proteins, eletriptan binds to 85%.
The half-life is approximately 4-5 hours. Metabolism occurs in the liver, after which the excretion occurs through the kidneys and the gastrointestinal tract.

Indications for use

It is used for the purpose of arresting migraine attacks with or without an aura manifestation.

Contraindications

The following contraindications for the use of Relpax are determined:
    high patient sensitivity to eletriptan and other components of the agent;
    reception for the purpose of arresting basilar, ophthalmoplegic, hemiplegic migraine;
    serious violations of liver function;
    rare hereditary diseases (glucose-lactose malabsorption, lack of lactase, lactose intolerance);
    simultaneous administration with CYP3A4 inhibitors and protease inhibitors;
    arterial hypertension with uncontrolled course;
    age to 18 years;
    Occlusal diseases of peripheral vessels;
    ischemic heart disease or suspected for the presence of this disease;
    transient ischemic attack and circulatory disturbances in the brain in the anamnesis;
    simultaneous treatment with other drugs - 5-HT1-receptor agonists.
Caution means prescribe to patients with serotonin syndrome. Also, you need to be careful, using Relpax at the same time as other agents with serotonergic activity.
Care should be taken when taking the drug at a dose of more than 40 mg to people who have a violation of kidney function.

Side effects

In most cases Relpax patients tolerate well. As a rule, the side effects are poorly expressed, they disappear on their own and are transitory.
Possible manifestations of the following side effects in the process of taking the remedy:
    rhinitis, pharyngitis, respiratory tract infections;
    lymphadenopathy;
    anorexia;
    mental disorders: confusion, disturbance of thinking, depression, euphoria, emotional lability;
    disorders in the work of the nervous system: headaches, drowsiness, dizziness, hypoesthesia, hypokinesia, sensitivity disorders, myasthenia gravis, hyperesthesia, tremor, ataxia, speech impairment;
    a feeling of restraint in the throat, yawning, dyspnea, change in the timbre of voice, asthma;
    hyperbilirubinemia;
    functions of the organs of vision: pain in the eyes, visual impairment, photophobia, conjunctivitis;
    function of the heart and blood vessels: tachycardia, palpitations, angina, bradycardia, increased blood pressure;
    organs of hearing, balance: ringing and pain in the ears, vertigo;
    functions of the gastrointestinal tract: abdominal pain, nausea, dry mouth, dyspepsia, diarrhea, constipation, belching;
    skin: severe sweating, itching, urticaria;
    musculoskeletal system: pain in the back, joints and muscles, arthritis, bone pain, arthrosis myopathy, convulsions;
    urinary system: polyuria, frequent urination;
    reproductive system: menorrhagia, pain in the mammary glands;
    allergic reactions;
    hot flushes to the face, asthenia, chills, chest discomfort, general weakness, thirst, peripheral edema.

Instructions for use Relpax (Method and dosage)

Instructions for use Relpax uses the drug inside. In this case, the tablets should be washed down with liquid.
If the patient is just beginning to develop migraine headache, you must take the pill as early as possible. But the expressed efficiency of its action is noted also at reception at the developed attack of a migraine.
Adult patients aged 18 to 65 years are recommended to take an initial dose of 40 mg.
When the headache recur during the day, you can re-take the remedy in a similar dose. If you need to take the pill again, then you can do it no earlier than 2 hours after taking the first pill.
If, after taking the first dose of Relpax, the headache does not decrease within 2 hours, then the second dose of the drug should not be taken.
But if you can not stop the attack, then an effective clinical response may appear in the next migraine attack. If a dose of 40 mg does not allow to obtain the desired effect, the next attack can take Relpax in a dose of 80 mg.
The total daily dose of the drug should not be more than 160 mg.
People suffering from mild or moderate impairment of liver function do not need to adjust the dose.

Overdose

In case of an overdose, the patient may develop arterial hypertension, as well as other cardiovascular system disorders. It is necessary to immediately wash the stomach, symptomatic treatment.
Since the half-life of the active substance is approximately 4 hours, with an overdose it is necessary to observe the patient for at least 20 hours until all the symptoms disappear.
There is no data on the effect of peritoneal dialysis and hemodialysis and on the concentration in the blood of eletriptan.

Interaction

The pharmacokinetics of eletriptan can be influenced by the simultaneous use of other drugs. If Erythromycin and Ketoconazole are simultaneously administered, Cmax eletriptan increased 2 and 2.7 times, respectively. The half-life of eletriptan also increased.
Therefore, Relpax is not prescribed concomitantly with Itraconazole, Ketoconazole, Clarithromycin, Erythromycin, Josamycin, as well as with protease inhibitors.
There was no interaction between Relpax and tricyclic antidepressants, β-blockers, SSRIs and flunarizine.
If you simultaneously receive Relpax, Propranolol and Verapamil or Fluconazole, then the maximum concentration of eletriptan increases. However, such changes do not have clinical significance.
If, after taking Relpax in 1-2 hours, caffeine or ergotamine is taken, this leads to a small but additive increase in blood pressure. Therefore, funds that contain ergotamine or ergotamine-like drugs should not be administered within 24 hours after Relpax's medication. Similarly, Relpax can be taken only 24 hours after taking such medications.
With simultaneous reception of eletriptan with drugs that demonstrate serotonergic activity, the risk of manifestation of serotonin syndrome increases. With this combination, patients need to be closely monitored.

Terms of sale

You don't need a prescription to buy Relpax.

Storage conditions

It is necessary to protect Relpax from children and store at a temperature not exceeding 30 ° C.
Shelf life - 3 years.

special instructions

Relpax is advisable to use only if the diagnosis of migraine is confirmed exactly. For the treatment of atypical headaches, which develop due to serious diseases, this drug is not prescribed.
You should not prescribe this remedy before conducting a thorough examination of the patient, who may have vascular and cardiac disease, and establish a diagnosis.
The effectiveness of tablets Relpax is noted both in the treatment of migraine with aura, and in the treatment of migraine without an aura and migraine, which is manifested relative to the menstrual cycle. If the tablets are used in the manifestation of the aura, it does not prevent the development of headaches. Tablets should be taken in the phase of the onset of headache development.
Relpax also alleviates other symptoms that occur with migraine: nausea, vomiting, phonophobia, photophobia.
Preventive reception of the drug is not allowed.
When using the drug in a dose of 60 mg or more, there may be a slight increase in blood pressure. More often this phenomenon is observed in the elderly and in patients with impaired renal function.
Many people with migraines are dizzy and drowsy, so during the attacks of the disease should be cautious to perform those actions that require increased attention.

Children

No pills are prescribed for children and adolescents under 18, since there is only limited information on the safety of the remedy for patients of this age.

In pregnancy and lactation

There is no experience of clinical use of Relpax during pregnancy. In the course of animal studies, teratogenic effects were not observed. Therefore, the appointment of an agent is advisable only if the intended benefit is significantly higher than the risk level for the fetus. It enters the breast milk.
If you take a dose of 80 mg once, then for 24 hours the excretion was 0.02% of the total dose. Minimize the risk of the effect of the drug on the baby can be provided that natural feeding stops for 24 hours after the eletriptan has been taken.

Reviews about Relpax

Feedback about Relpax indicate that the remedy is very effective against migraines. In the reviews we are talking about the fact that after taking the pill the patients completely disappeared symptoms of migraine attacks. The intensity of symptoms decreases about 30 minutes after taking the pill.
Side effects may include drowsiness, tremors, nausea, and other side effects. In the reviews it is noted that after taking the tablets it is advisable to sleep, in order to minimize the risk of developing side effects. However, some people suffering from migraine, note that Relpax was ineffective for them.