Lopedium 2mg #10

Composition

One tablet contains loperamide hydrochloride - 2 mg.
Additional ingredients: talc, lactose monohydrate, magnesium stearate, corn starch, gelatin, E172, titanium dioxide, E131.

Form of issue

Oval capsules, half gray, half green. Inside is a uniform white powder. Packages of 10,20, 30 and 50 pieces.

pharmachologic effect

What is Lopedium from? The drug has the property to suppress intestinal peristalsis. Has antidiarrhoeal effect.

Pharmacodynamics and pharmacokinetics

Loperamid is a synthetic derivative of piperidine. It affects the peripheral opioid receptors, reducing the production of acetylcholine and prostaglandins. Thus, there is a decrease in the propulsive peristalsis of the small intestine, defecation occurs with a lower frequency, and the feces acquire a more firm consistency.
Indications for the use of the drug are frequent bouts of diarrhea. This is due to the ability of the means to increase the tone of the anal sphincter, to reduce the frequency of defecation.
After taking the pills, they quickly enter the bloodstream, after being absorbed into the digestive tract. After 4-5 hours after administration, loperamide reaches its maximum concentration in the blood plasma and, in a rather small amount, can penetrate the blood-brain barrier.
It undergoes metabolic reactions in the liver, is excreted after 9-14 hours with colonic masses, a small amount - through the kidneys.
Due to the fact that the drug is metabolized in the liver, it is necessary to consult a doctor and adjust the dose for patients with liver diseases.

Indications for use

The drug can be prescribed for any type of diarrhea.

Lopedium - from what these tablets?

    treatment of chronic, allergic, emotional, medicinal and radiation diarrhea;
    additional remedy for the treatment of infectious diseases of the digestive tract (together with antibiotics);
    diarrhea caused by a change in dietary habits, metabolic disorders, certain diseases of Lymphocytes;
    elimination of diarrhea with ileostomy.

Tablets Lopedium - from what?

Indication for the use of the drug can also be a digestive disorder in tourists (traveler's diarrhea). Capsules can be taken within 2 days. In case of blood in the stool, consult a doctor.

Contraindications

    severe allergic reactions to the components of the drug;
    acute dysentery (blood in feces, fever);
    age up to six years;
    bacterial enterocolitis (salmonellosis, shigellosis);
    acute colitis caused by taking antibiotics;
    during the application of the product there is bloating, constipation, intestinal obstruction.

Side effects

Possible:
    headache, tremor, drowsiness and loss of consciousness;
    retention of urine, miosis;
    constipation, nausea, indigestion, megacolon;
    Stevens-Johnson syndrome, angioedema, itching on the skin and urticaria.

Lopedium, instructions for use (Method and dosage)

Capsules take whole, do not bite, wash down with water.
According to instructions for the use of Lopedium, it can be prescribed to adults and children, starting at six years of age.
For adults, with chronic or acute diarrhea, the initial dosage is 4 mg, after each trip to the toilet (act of defecation). The dosage can then be reduced to 2 mg. The maximum drug taken for a day is 16 mg.
For children, initially prescribed 2 mg, a maximum of 6 mg per day.
The course of treatment ends when the state is reached, when the time between two acts of defecation is at least 12 hours.

Overdose

Symptoms of overdose is a strong suppression of the central nervous system, including urine retention, intestinal obstruction, severe CNS depression, stupor, miosis, convulsions. It should be remembered that children are more sensitive to the drug than adults.
Naloxone is a specific antidote to the drug. You may need to re-administer the antidote. Do not exclude and symptomatic therapy, gastric lavage, reception of enterosorbents.

Interaction

Do not combine medicine with other drugs that depress the central nervous system.
Take with caution with P-glycoprotein inhibitors (quinidine, ritonavir), inhibitors of CYP3A4 (Gemfibrozil), Itraconazole, Desmopressin, ketoconazole.

Analogues:

Imodium.

Terms of sale

Prescription is optional.

Storage conditions

In a dark place inaccessible to children, at a temperature of not more than 30 degrees.

Shelf life

5 years.

In pregnancy and lactation

Taking medication during pregnancy and during breastfeeding is highly discouraged. You should consult a doctor who, in turn, will choose another suitable drug.

Reviews about Lopedium

Reviews on the forums are good. Everyone who took the drug is satisfied with the result, the medicine quickly and effectively copes with the delicate problem of frequent trips to the toilet. Sometimes patients had enough one or two techniques to bring the stool back to normal. Another advantage is considered to be low cost, in comparison with its analogues. However, there are isolated cases of allergy to the active substance or side effects.