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Motilium 10mg #30

  • $29.19
  • 3 or more $26.30
  • Availability:In Stock

Motilium user manualReed more and buy Motilium hereCompositionRegardless of the form of release, the drug includes domperidone as an active substance in the formulation.Suspension Motilium contains the following additional compone..

Motilium user manual

Reed more and buy Motilium here


Regardless of the form of release, the drug includes domperidone as an active substance in the formulation.
Suspension Motilium contains the following additional components: sodium saccharinate, sodium carboxymethyl cellulose, methyl parahydroxybenzoate, sodium hydroxide, water, MCC, sorbitol, propyl parahydroxybenzoate, polysorbate.
Excipients of the resorption tablets are gelatin, aspartame, poloxamer 188, mannitol, mint essence.
Tablets Motilium in the shell include lactose, microcrystalline cellulose, polyvidone, vegetable hydrogenated oil, hypromelose, corn starch, gelatinized potato starch, magnesium stearate, sodium lauryl sulfate.

Form of issue

The medicine is available in the form of biconvex circular tablets cream or white. On the sides there are engravings "Janssen" and "M / 10".
In addition, white instantly dissolving tablets and a suspension (or syrup) are sold in vials.

pharmachologic effect

The summary of the preparation indicates that it is an anti-emetic, which activates the gastrointestinal motility.

Pharmacodynamics and pharmacokinetics

The drug inhibits dopamine receptors. This property in combination with gastrokinetic action causes the antiemetic effect of the drug.
With internal application, Motilium increases the pressure of the lower sphincter of the esophagus, accelerates the purification of the stomach and improves the anthroduodenal motility.
After taking an empty stomach, the active substance of the preparation is absorbed from the digestive tract in a short time. The degree of absorption of domperidone is reduced due to a decrease in the acidity of gastric juice. The maximum concentration in plasma is noted after about 0.5-1 hour. In people with a disability of the liver of moderate severity, it can be 1.5 times higher than that of healthy ones.
Absolute bioavailability is about 15%. When using the medicine after meals, the maximum concentration is reached later. In healthy people, bioavailability increases when applied after a meal. If there are problems with the gastrointestinal tract, you should use the drug 15-30 minutes before meals.
The degree of connection of the active substance with plasma proteins is 91-93%. Once ingested, it undergoes rapid and active biotransformation in the liver through hydroxylation and N-dealkylation.
The drug is 31% excreted in the urine and 66% with feces. About 11% of the active substance is excreted unchanged.
The half-life of plasma after a single application is 7-9 hours. In people with severe renal failure, the half-life increases to 20.8 hours, and plasma concentration decreases. Only about 1% is excreted through the kidneys in an unchanged form. In people with a disability of the liver, the elimination half-life is 15-23 hours.

Indications for the use of Motilium

Indications for the use of Motilium: vomiting, hiccough, nausea, atony and hypotension, cholecystitis, reflux esophagitis, peptic ulcers of the intestine, the need to accelerate peristalsis to radiopaque studies of the digestive tract, dyskinesia of the biliary tract, cholangitis, flatulence.
As a component of complex treatment, the drug is taken with exacerbation of peptic ulcer of the stomach and duodenum.
Indications for the use of Motilium for children: gastroesophageal reflux, cyclic vomiting, regurgitation syndrome.


The medicine has the following contraindications:
    bleeding in the digestive tract, perforations, mechanical obstruction;
    negative reaction of the body to the components of the drug;
    severe or moderate liver dysfunction.
With caution, the drug is taken with dysfunction of the kidneys, as well as violations of rhythm and conduction of the heart.
For possible contraindications to the use of a drug, it is advisable to consult with a specialist.

Side effects

When taking this medication, the following adverse reactions are possible:
    endocrine system: amenorrhea, hyperprolactinemia (in rare cases can cause galactorrhea), gynecomastia;
    Gastrointestinal tract: spasms in the intestine;
    allergies: urticaria, rash;
    nervous system: extrapyramidal disorders.
Negative effects are noted only in extremely rare cases.

Instructions for the use of Motilium (Method and dosage)

Instructions for use Motilium informs that the reception scheme may be different depending on what tablets or suspension are used in each particular case.
In the case of chronic dyspepsia, adults need to take a medication of 10 mg (1 tablet) on an empty stomach 3 times / day. If necessary, you can apply the drug before bedtime. For those using the suspension and Motilium tablets, the instructions for use do not recommend a daily dosage of 80 mg.
Syrup to children given in a dosage of 2.5 ml of medicine per 10 kg of weight. Do this 3 times / day on an empty stomach. If necessary, take the medicine before bed.
Instructions for use Motilium for children from 1 year also informs you that if necessary, the dose can be increased 2 times. The maximum dosage per day is 2.4 mg / kg, but not more than 80 mg.
In case of nausea and vomiting, take a syrup in a dosage of 20 ml or 2 tablets. Do this 3-4 times / day on an empty stomach and before bedtime. The daily dosage is not more than 80 mg.
Suspension for children is given at the rate of 5 ml of the drug per 10 kg of weight. The medicine is taken 3-4 times / day on an empty stomach and before bedtime. The maximum daily dosage is 2.4 mg / kg, but not more than 80 mg.
Tablets can be given only to adults and children weighing 35 kg. If the body weight is less, you need to use the so-called children's Motilium in the form of a syrup.
Before use, the vial with suspension should be shaken well. To open it, you need to press the plastic cover and turn it. Next, the lid is removed, in which the motilium suspension is located, the instruction for use informs that it should be recruited only with the aid of a special pipette that comes with the preparation.


Symptoms of overdose: drowsiness, extrapyramidal reactions, disorientation.
There is no special antidote. In case of an overdose, it is advisable to wash the patient's stomach and give Activated Carbon. It is necessary to observe the patient's condition and carry out supporting activities.
In the case of extrapyramidal reactions, anticholinergic and antihistamines may be effective.


Anticholinergics can block the effect of Motilium. Antifungal drugs of the azole group, HIV protease inhibitors and antibiotics belonging to the macrolide group can inhibit biotransformation of domperidone and increase its content in blood plasma, so this combination should be administered with caution.
Contraindicated the simultaneous use of Motilium and ketoconazole in oral form, as well as Erythromycin and strong inhibitors of the isoenzyme CYP3A4, which cause an elongation of the QT interval.

Terms of sale

Without recipe.

Storage conditions

The optimum temperature is 15-30 ° C. The medicine is stored in a place inaccessible to young children.

Shelf life

Five years.

Motilium for children

Suspension Motilium for children can be used even with body weight up to 35 kg. When using the drug, you need to monitor the condition of the child. The most common adverse reactions in childhood are extrapyramidal reactions.

During pregnancy (and lactation)

Data on the effect of the drug during pregnancy is not enough. Information about the risk for the fetus is not available. However, it is advisable to take the drug during pregnancy only if the benefit of the treatment is more than a potential threat to the fetus.
When breastfeeding, the concentration of the active substance of the drug is 10-50% of its level in the blood plasma. It is not known whether the drug has a negative effect on the newborn. Reception of the remedy is also possible only if the benefit to the mother is greater than the possible risk to the baby.

Reviews about Motilium

Reviews of Motilium characterize the drug as a highly effective quick-acting agent. It is very popular with consumers. Reviews about Motilium for children are also mostly positive. Often this remedy is recommended by pediatricians, but not for babies. In the latter case, the action of the agent has not been studied. In addition, the medicine is rarely used by nursing mothers, since its harm to lactation has not been studied.
Among the negative aspects, those who took Motilium, note only a little overpriced.

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