Urdoxa caps 250mg #100

Urdoxa instruction

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Composition

The tablet contains 250 mg of ursodeoxycholic acid + magnesium stearate, corn starch, titanium dioxide, colloidal anhydrous silicon dioxide, methylhydroxybenzoate, acetic acid, gelatin, propylhydroxybenzoate.

Form of issue

The preparation is released in the form of small opaque gelatinous capsules. Color: white or almost white. Capsules are solid, inside each is a white or almost white powder.
Capsules are sold in cell contour packs, 1,2,3,4,5 packs in a carton pack. Or in banks of 50 or 100 pieces.

pharmachologic effect

Hepatoprotector, choleretic and cholelitholytic agent.

Pharmacodynamics and pharmacokinetics

In addition to hepatoprotective and choleretic action, the drug has the ability to lower cholesterol and stimulate the immune system.
Ursodeoxycholic acid is incorporated into the membrane membrane of hepatocyte cells, thus stabilizing their structure and protecting cells from the influence of bile acid salts. The drug has the ability to reduce the level of dangerous acids - chenodeoxycholic, deoxycholic and others, stimulates the activity of calcium-dependent alpha protease.
The drug reduces the synthesis of cholesterol in the liver and its concentration in the bile, stimulates the production of bile and its release. There is an intensification of punkeretic and gastric secretion.
When taken orally, it has the ability to dissolve cholesterol stones and lower cholesterol levels, in general. The agent increases the number of T-lymphocytes, the formation of IL-2, reduces the number of eosinophils, thereby stimulating cellular immunity.
Absorption of the agent occurs in the small and ileum. The maximum concentration in blood plasma - 5.5 mmol per liter is observed after about an hour. The active substance is almost completely (up to 99%) bound to plasma proteins. The effectiveness of the drug is linearly dependent on the concentration of this acid in the bile and the amount of the drug taken.
Metabolism means undergoes in the liver, then its active metabolites are secreted with bile (about 60%). Only a small part of it is split by bacteria in the large intestine.

Indications for use

Indication for the use of the drug is:
    biliary reflux-gastritis;
    primary cirrhosis, without decompensation;
    the need for dissolution of gallstones of small and medium-sized gall bladder, with its normal functioning.

Contraindications

The drug is contraindicated for use:
    with acute inflammatory diseases of the intestine, gallbladder and ducts;
    with severe diseases of the kidneys, liver and pancreas;
    pregnant and lactating women;
    if the gallbladder ceased to function;
    in the presence of gallstones with a high content of calcium;
    children (up to 18 years);
    with decompensated liver cirrhosis;
    when allergic to the components of the remedy.

Side effects

The most frequent manifestations are: pain in the epigastric region, right hypochondrium; abdominal pain; constipation or diarrhea.

Also possible:

    calcification of gallstones;
    increased liver enzymes;
    nausea and vomiting;
    dizziness;
    psoriasis;
    alopecia;
    allergies, rashes on the skin, hives.

Urdoxa, instructions for use (method and dosage)

The medicine is taken orally, washed down with water, without dividing or cracking the capsule.
The dosage of the drug and the duration of admission vary depending on the disease, are appointed by the attending physician.

Instructions for use Urdoxa

For the treatment of primary biliary cirrhosis the dosage is selected depending on the weight:
    if the weight of the patient is up to 50 kg, then appoint 2 capsules, dividing into two doses;
    with a body weight of 51 to 65 kilograms, 3 capsules are prescribed per day for 3 doses;
    if the weight is from 66 to 85 kg - one tablet in the morning, one at lunch and 2 at bedtime;
    with a weight of 86 to 110 kg - one tablet in the morning, 2 in the afternoon and 2 in the evening;
    if the patient's weight is more than 110 kg, then the daily dosage will be equal to 6 capsules divided into 3 doses.
To dissolve cholesterol gallstones, appoint 250-500 mg of medication per day (1 or 2 tablets). The drug is taken after and during meals, for 4-12 months. As prevention, 1 tablet is prescribed per day.
To treat biliary reflux gastritis, appoint 1 capsule, 1 time per day. Duration of admission is determined by the individual doctor.

Overdose

No cases of overdose by the agent have been reported. If overdosing does occur, then colstriamine should be taken, which forms chelate complexes with bile acids.

Interaction

It is not necessary to combine the drug with colestyramine and other means that reduce the degree of absorption of bile acids in the intestine, estrogens, lipid-lowering agents, hormonal contraceptives, hepatotoxic drugs.

Storage conditions

Store the medicine in a dry, cool place, without direct access to the sun. Keep away from children.
Shelf life - 4 years. If the expiration date has expired, the drug should not be taken extremely.

special instructions

If the drug is used to dissolve stones in the gallbladder, to achieve a good result and reduce the likelihood of adverse reactions, certain conditions must be met:
    the size of stones - no more than 20 mm;
    stones should be X-ray negative;
    the gallbladder should not be inflamed, should continue to function;
    The bubble can be filled with stones no more than half.
Each month (at the initial stages) or 3 months (treatment for about six months), it is necessary to control the level of liver enzymes. Then, within 3 months, after the complete dissolution of the stones, the drug should be taken for prophylaxis.

Ursosan or Urdoxa - which is better?

The original and its analogue are no different from each other. Urdoxa and Ursosan are the same medicines. The only difference is in the producing country. Urdoxa is a domestic analog of Ursosan, while raw materials for the preparation are purchased abroad. In this regard, both drugs can differ unless costly. In this case, Urdoxa is somewhat cheaper than its counterpart.

Reviews about Urdoxa

On the Internet, there are mostly positive reviews about Urdoks. People taking the medicine were mostly satisfied with the result. Some complain of adverse reactions in the form of hair loss, back pain and nausea.