Ursosan caps 250mg #50

User manual for Ursosan

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Composition

The composition of the medication is
    the active ingredient is ursodeoxycholic acid;
    additional components - corn starch, silicon dioxide colloid, gelatin, magnesium stearate, titanium dioxide.

Form of issue

Drug Ursosan is sold in hard capsules of white color. Inside the capsules is a white powder.

pharmachologic effect

The drug is hepatoprotective, it also works as choleretic, lipid-lowering, immunomodulating, cholelitholitic and hypocholesterolemic.

Pharmacodynamics and pharmacokinetics

The composition determines the effect of this medication. Its active component is ursodeoxycholic acid. Wikipedia and many other sites call this drug this way. Ursodeoxycholic acid has high polar properties and creates nontoxic mixed micelles with toxic bile acids. This leads to a decrease in the ability of gastric reflux to damage the cell membranes with the appearance of reflux esophagitis and biliary reflux gastritis. In addition, the drug Ursosan creates double molecules that enter the cell membranes of hepatocytes, epitheliocytes of the gastrointestinal tract, cholangiocytes. These molecules stabilize them and make them immune to the effect of cytotoxic micelles.
The active substance of the drug also reduces the content of bile acids, which are toxic to hepatocytes, and stimulates choleresis saturated with bicarbonates. Due to this, intrahepatic cholestasis disappears. Ursodeoxycholic acid reduces the lithogenic bile index and cholesterol concentration by preventing its absorption in the intestine, reducing secretion in the bile, suppressing synthesis in the liver. As a result, cholesterol gallstones dissolve. The remedy also prevents the appearance of new concrements.
The drug acts as an immunomodulatory agent by suppressing the expression of HLA-2 and HLA-1 antigens and improving the normal killer activity of lymphocytes. In addition, it interferes with the development of fibrosis in people with primary biliary cirrhosis, as well as with alcoholic steatohepatitis and cystic fibrosis. Reduces the likelihood of varicose veins in the esophagus, slows premature aging and cell death.
The active substance of the drug is absorbed from the small intestine through passive diffusion (the degree of absorption is approximately 90%), and in the ileum - through active transport. The maximum concentration is reached after about 60-180 minutes.
Degree of communication with plasma proteins up to 99%. With constant use ursodeoxycholic acid becomes the main bile acid in the blood serum. The therapeutic effect of the drug depends on its content in the bile.
The drug is cleaved in the liver with the formation of such metabolic products as glycine and taurine conjugate. They are secreted in bile. Approximately 60% of the total dosage is excreted with bile. Some of the active substance is also transported to the large intestine, where it is broken down by bacteria. Lithocholic acid is absorbed to a small extent from the large intestine, sulphated in the liver and is excreted as a sulfolithocholylglycine or sulfolitocholyltaurine conjugate.

Indications for use of Ursosan

On forums are often interested in, from what tablets can help in this or that case. Experts do not recommend taking them without consulting a doctor. Only he can determine whether there is evidence for the use of Ursosan. In addition, he selects the desired treatment regimen.
If you are prescribed Ursosan tablets, the indications for use are usually the following:
    uncomplicated cholelithiasis;
    the need to prevent the recurrence of stone formation after cholecystectomy;
    acute hepatitis;
    alcoholic disease and primary biliary cirrhosis;
    biliary dyskinesia;
    cystic fibrosis of the liver;
    biliary dyspeptic syndrome;
    toxic liver damage;
    chronic active hepatitis;
    non-alcoholic steatohepatitis;
    atresia of the intrahepatic biliary tract;
    primary sclerosing cholangitis;
    biliary reflux gastritis and reflux esophagitis;
    the need to prevent liver damage when taking hormonal contraceptives and cytotoxic drugs.

Contraindications

This drug can not be used for hypersensitivity to its components, dysfunctional gallbladder, chronic hepatitis, pancreatitis, acute cholecystitis, liver cirrhosis (with decompensation), acute cholangitis, acute infectious diseases of the gallbladder, diseases of the bile duct, pregnancy, breast-feeding, bile -gastrointestinal fistula, gallstones with high Ca2 + content, inflammatory diseases of the small and large intestine, hepatic insufficiency, renal insufficiency, empyema e gallbladder, obturation of the biliary tract.

Side effects of Ursosan

Reviews of side effects appear infrequently. However, if any undesirable reactions occur, you should definitely consult a doctor.
The following side effects of Ursosan are known:
    vomiting;
    exacerbation of psoriasis;
    nausea;
    diarrhea;
    transient increase in hepatic transaminase activity;
    constipation;
    pain in the back;
    allergy;
    alopecia.
In rare cases calcification of gallstones is possible.

Instructions for use Ursosan (Method and dosage)

Those who have been prescribed Ursosan tablets, the instruction for use informs that they should be taken orally, while washing with liquid.
The medicine has different reception schemes depending on the disease. For those who are interested in how to take Ursosan: before meals or after - it is also reported that this is individually depending on the indications for use.
In the case of diffuse liver disease and cholelithiasis, the course of treatment can last from several months to several years, the daily dosage is usually 10-15 mg per 1 kg of the body weight of the patient (2-5 capsules). In cholelithiasis, the daily dosage is taken once just before bedtime. The treatment is carried out until the stones are dissolved, and then 3 more months so that the stones do not form again. In case of diffuse liver disease, the instruction on the use of Ursosan informs that the daily dosage should be divided into 2-3 doses. The drug should be taken during meals.
After cholecystectomy and with the goal of preventing recurrent cholelithiasis, as a rule, 250 mg 2 times during the day are prescribed. The course is designed for several months.
In primary biliary cirrhosis, the drug is taken in a dosage of 10-15 mg per 1 kg of patient's body weight per day. If necessary, it can be increased to 20 mg per 1 kg. Dosage should be divided into 2-3 doses. The course of treatment lasts from 6 months to several years.
If the patient has non-alcoholic steatohepatitis, take 13-15 mg per 1 kg of the patient's weight per day. Dosage should be divided into 2-3 doses. The course of treatment can last from 6 months to several years.
In the case of biliary reflux gastritis and reflux esophagitis, the drug is taken 1 capsule (250 mg) per day just before bedtime. Therapy is carried out from 10 days to 6 months. If necessary, it can be extended to 2 years.
With liver damage, atresia of the biliary tract and alcoholic liver disease, the daily dosage is usually 10-15 mg per 1 kg of the patient's weight. The daily dosage should be divided into 2-3 doses. The course is designed for six months, a year or more.
If the patient has primary sclerosing cholangitis, the doctor usually prescribes 12-15 mg per 1 kg of the patient's body weight per day. If necessary, the dosage can be increased to 20 mg per 1 kg of body weight. The total daily dose is divided by the patient for 2-3 sessions. The course of admission - from six months to several years.
In cystic fibrosis, the drug is taken in dosages of 20-30 mg per kg per day. The dose should be divided into 2-3 doses. The course lasts from six months to several years.
For children from 2 years, the amount of medication taken per day is established by a specialist individually. Usually prescribe 10-20 mg per kg per day.
In order to eliminate expressed and dangerous jaundice, specialists in some cases prescribe this remedy to newborns. The therapy is designed for 2-4 weeks. Instruction for the use of Ursosan to newborns informs that dosage for children of this age is a quarter of a capsule every day. The powder in it is poured out on the saucer. Then it is divided into four equal parts, one of which is given to the infant. Pre-it must be dissolved in water or breast milk. If the treatment is successful, the course can be reduced to 10 days. It is necessary to observe the content of bilirubin in the blood every week. On average, for a week its level is reduced by 50 units. After the concentration in the blood is 100 mg / ml, the medicine can be canceled.

Overdose

No overdose of this drug was reported.

Interaction

Antatsidy with Al3 + and ion-exchange resins can reduce the degree of absorption of the drug. Lipid-lowering drugs, estrogens, and Neomycin or progestins increase cholesterol levels in bile and decrease the degree of dissolution of cholesterol bile stones.

Storage conditions

Keep capsules in a dry, inaccessible to children and well protected from sunlight penetration. The optimum temperature regime is up to 25 ° C.
Shelf life - Four years.

Ursosan for newborns

Reviews of this drug indicate that it is effective for newborns if there are appropriate indications. With a high concentration of bilirubin in the blood, infants can develop physiological jaundice.
Ursosan in this case has its own established scheme of application.

With alcohol

Since the drug among the indications has alcoholic liver damage, it was checked for compatibility with alcohol. After all, people who take this drug, it is difficult to abandon the addiction, even if it has already affected the body in an unfavorable manner. As a result of the research, it was found that the drug does not lose its effectiveness when consuming alcoholic beverages. This is confirmed by the improvement of biochemical parameters of blood in people with such dependence.

Ursosan during pregnancy (and lactation)

In pregnancy, this drug is recommended to be taken only if the intended benefit for a woman exceeds the possible risk for the child.
During breastfeeding, use of this drug is not desirable, since there is no data on the interaction of its active substance with breast milk.

Reviews about Ursosan

Reviews on the treatment of the drug can often be found at specialized forums. Including, express their opinion and doctors. They note the effectiveness of this drug. Patients' reviews are also predominantly positive. Some take it and as a preventive agent in cases where a heavy load on the liver is expected.
In terms of use for newborns, doctors' reviews of Ursosan tend to report that the treatment was effective. Parents turn to them when children develop jaundice. Those who gave the medicine according to the requirements of a specialist, leave comments about Ursosan, which say that the drug helped.