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Acetylcysteine tabs 600mg #12

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  • $15.55
  • 3 or more $15.20
  • Availability:In Stock

Acetylcysteine instructionYou can buy Acetylcysteine onlineCompositionThe drug has as its main substance Acetylcysteine. Additional components in tablets are ascorbic acid, saccharin, sucrose, flavoring.Each package of powder, in ..

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Acetylcysteine instruction

You can buy Acetylcysteine online

Composition

The drug has as its main substance Acetylcysteine. Additional components in tablets are ascorbic acid, saccharin, sucrose, flavoring.
Each package of powder, in addition to the main substance, contains a flavor additive "Aromatic" Lemon, lactose monohydrate, aspartame.

Form of issue

The medicine is released as a solution for internal use or capsules. In addition, such a form of release as effervescent tablets is known.

pharmachologic effect

Mucolytic action.

Pharmacodynamics and pharmacokinetics

About Acetylcysteine, what is it and what is the mechanism of its action, it is important to know before using the drug. It is an amino acid derivative of cysteine. The effect of the drug Acetylcysteine ​​is due to the fact that its sulfhydryl group cleaves the disulfide bonds of acid mucopolysaccharides of sputum. This causes mucolytic effect. Mukoregulatory activity depends on the increase in secretion of less viscous sialomucins by goblet cells. On the epithelial cells of bronchial mucosa adhesion of bacteria decreases. This is due to a decrease in the viscosity of sputum and an increase in mucociliary clearance.
The disinfecting effect of the drug is due to the action of a free sulfhydryl group, which affects the electrophilic oxidative toxins, neutralizing them.
This drug protects cells from free radicals both through direct interaction with them, and by transporting cysteine ​​for the synthesis of glutathione.
The drug is quickly broken down by internal application. But its bioavailability is about 10%. The degree of connection with plasma proteins is 50%. The maximum concentration in the plasma is observed after 60-180 minutes. The active substance can enter through the placental barrier and accumulate in the amniotic fluid. Half-life is 60 minutes. With cirrhosis of the liver - up to 8 hours.
Excreted mainly by the kidneys as inactive metabolites. Some part is unchanged in the intestine. In plasma is determined in an unchanged form, as well as a metabolite of N-Acetylcysteine, cysteine ​​ester and N, N-diAcetylcysteine.

Indications for use

The drug is used for difficult sputum separation, lung abscess, laryngotracheitis, bronchial asthma, catarrhal and purulent otitis, removal of the viscous secretion from the airways after operations, and also in the case of post-traumatic conditions. In addition, interstitial lung diseases, cystic fibrosis, pulmonary emphysema, lung atelectasis, sinusitis, poisoning with paracetamol appear among his indications.

Contraindications

Do not use this tool for exacerbation of gastric ulcer and duodenal ulcer, pulmonary hemorrhage, hypersensitivity to the drug, hemoptysis, pregnancy.

Side effects

The drug can lead to the appearance of such adverse reactions as:
    rash, itching, urticaria, bronchospasm;
    nausea, heartburn, stomatitis, vomiting, sensation of a full stomach;
    drowsiness;
    fever.
In rare cases, noise in the ears, burning at the injection site (in case of using the solution), as well as reflex cough, rhinorrhea and local irritation of the respiratory tract during inhalation use are possible.

Instructions for use Acetylcysteine ​​(Method and dosage)

Dosages are selected depending on the age and nature of the patient's illness.
Instructions for use Acetylcysteine ​​reports that for children 2-6 years of age, a daily dosage of 100 mg 3 times or 200 mg 2 times is usually indicated. The drug is used in the form of a water-soluble granulate. And for children under 2 years of age, a daily intake of 2 times 100 mg is prescribed. In turn, children 6-14 years are given twice daily 200 mg, in the case of cystic fibrosis, 200 mg 3 times. The medicine can be taken in the form of effervescent tablets, capsules or granules.
Adults take 200 mg of the drug every day 2-3 times in any possible form of release.
For aerosol therapy, 20 ml of a solution of 10% in ultrasonic devices are sprayed, and in the devices with a control valve, 6 ml of a solution of 10% are sprayed. Inhalation is done every day 15-20 minutes 2-4 times. In acute conditions, therapy is 5-10 days, with chronic - up to six months.
With a strong secretolytic action, it is necessary to suck the secret, and also reduce the frequency of application and dosage of the drug.

Overdose

The medicine in case of an overdose can cause diarrhea, nausea, pain in the stomach, heartburn, vomiting.
Therapy is symptomatic. In case of severe symptoms of overdose, it is necessary to consult an expert immediately.

Interaction

The combination of the drug with oral administration of semisynthetic penicillins, cephalosporins, tetracyclines (with the exception of Doxycycline), aminoglycosides requires a two-hour interval. Acetylcysteine ​​with other antitussive medicines can cause dangerous stagnation of mucus. When combined with this drug may also increase the vasodilating effect of nitroglycerin.

Storage conditions

Optimal storage conditions Acetylcysteine: dry, dark place, inaccessible to children, temperature not higher than 25 ° C, hermetic packaging.
Shelf life - Five years.

Reviews

This drug receives a variety of reviews. Many of them are positive. Those who have tried this tool report its effectiveness. However, there are also negative opinions about Acetylcysteine. They write about the fact that the drug did not help. Therefore, people often start looking for other, more effective means.

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